Protein Alignment CG4707 and PLAG1

DIOPT Version :10

• Sequence 1: NP_611944.1
• Gene: CG4707 / 37935
• FlyBaseID: FBgn0035036
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_002646.2
• Gene: PLAG1 / 5324
• HGNCID: 9045
• Length: 500
• Species: Homo sapiens
• Alignment Length: 236
• Identity: 58/236 - (24%)
• Similarity: 106/236 - (44%)
• Gaps: 22/236 - (9%)

  Fly   416 KAEPKEKRIYQCEKCPKSFTTKAAMEYHDVSKHVPKSEFKYSCPECNKKIPTERKLKEHLRYMHD 480
            :.|.|.::.:.|:.|.|:|.:...::.|..| |..:..:|....:|.|...::.||:.|:. .|.
Human    25 RGETKPRKNFPCQLCDKAFNSVEKLKVHSYS-HTGERPYKCIQQDCTKAFVSKYKLQRHMA-THS 87

  Fly   481 PEAAIICDKCGKTLRSQTNLKKH---HELEHSEKPRPKPDPVQCEICGTWLRHLSGLKQHMKTVH 542
            ||....|:.|.|....:.:||.|   |:        |..:..:||.||.......|.|:|: .:|
Human    88 PEKTHKCNYCEKMFHRKDHLKNHLHTHD--------PNKETFKCEECGKNYNTKLGFKRHL-ALH 143

  Fly   543 EPPGDEHRCHICNKTSTNSRALKRHIYHNH-------LCERKFKCGMCEKAFKRPQDLREHTSTH 600
            .....:..|.:|.:|..::..|..|: .:|       :.|:|.:|..|::.|...:|:|.|...|
Human   144 AATSGDLTCKVCLQTFESTGVLLEHL-KSHAGKSSGGVKEKKHQCEHCDRRFYTRKDVRRHMVVH 207

  Fly   601 TGEVLYTCPNCPMTFFSNANMYKHRQRLHRAEWEADRKKPL 641
            ||...:.|..|...|....::.:|.::.|..|....:.:|:
Human   208 TGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLKVKTEPV 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4707	NP_611944.1	zf-AD	3..77	CDD:462262
		C2H2 Zn finger	334..355	CDD:275368
		LIM	<361..407	CDD:413332
		C2H2 Zn finger	365..382	CDD:275368
		C2H2 Zn finger	390..410	CDD:275368
		C2H2 Zn finger	427..443	CDD:275368	4/15 (27%)
		COG5236	<455..>574	CDD:227561	31/128 (24%)
		C2H2 Zn finger	458..476	CDD:275368	5/17 (29%)
		C2H2 Zn finger	487..507	CDD:275368	7/22 (32%)
		C2H2 Zn finger	521..540	CDD:275368	7/18 (39%)
		C2H2 Zn finger	551..572	CDD:275368	5/20 (25%)
		C2H2 Zn finger	580..600	CDD:275368	6/19 (32%)
		C2H2 Zn finger	608..629	CDD:275368	4/20 (20%)
PLAG1	NP_002646.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		1/4 (25%)
		Interaction with KPNA2. /evidence=ECO:0000269|PubMed:11882654	2..84		15/59 (25%)
		Nuclear localization signal	22..25		58/236 (25%)
		C2H2 Zn finger	36..56	CDD:275368	6/20 (30%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm	41..242		53/212 (25%)
		SFP1	<58..139	CDD:227516	23/89 (26%)
		C2H2 Zn finger	64..86	CDD:275368	5/22 (23%)
		zf-H2C2_2	79..101	CDD:463886	8/22 (36%)
		C2H2 Zn finger	94..114	CDD:275368	6/19 (32%)
		C2H2 Zn finger	123..143	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	5/20 (25%)
		C2H2 Zn finger	187..207	CDD:275368	6/19 (32%)
		C2H2 Zn finger	215..233	CDD:275368	4/17 (24%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction	243..500		1/6 (17%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity	243..384		1/6 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..388
		Massively activates transcription	385..500