DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4707 and CG17568

DIOPT Version :9

Sequence 1:	NP_611944.1	Gene:	CG4707 / 37935	FlyBaseID:	FBgn0035036	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_609951.2	Gene:	CG17568 / 35198	FlyBaseID:	FBgn0032763	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	695	Identity:	140/695 - (20%)
Similarity:	232/695 - (33%)	Gaps:	239/695 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CVLCL-DSSNAGYGLQSEEGVRLN----IRATIHKHFAFSEVLTAGGDAEVCRECWNCVSSFEEF 63
            |.||. |.::....:|..|..:.|    :...|.|:|.....|.....:.:|.||:..:|...:|
  Fly    11 CRLCAKDDAHGNVKVQMNENSQGNWDNVLIMAIRKYFEVQMQLEDELSSVLCTECYTLISELIDF 75

  Fly    64 HQRVSCLH------RQRSSDSKSE--------PIEFCGQTEEAIINPLYSVELDALAEAFFAPSE 114
            .:.|:.:.      |:..:|...|        ....|......||.|:.::|::: ...:..|:|
  Fly    76 AEHVTKVQDIFEVLRRTETDGDQEMDVAALRQQFGLCDDDWTHIIKPIPALEMES-DNVYQKPAE 139

  Fly   115 VKVEVNELEPLPKVELLEDPVKTEIRTAPKRLGVPNEGSPHSKRRIKNELPVDSDSDAPLADFLN 179
            :      |:..|..|.....::...||....|       ..:|:.::.|:|..        :|::
  Fly   140 L------LKDFPLAETSSQEMEISKRTTTTHL-------IQTKKNVEMEIPKQ--------EFID 183

  Fly   180 SDSKRSSVGP---AKNSEANKGRQLRRSARRGRPPKAKPESAPSPKKELDSEDGEENARDNNDME 241
                   :||   .||:                             .:||.||
  Fly   184 -------LGPILLEKNT-----------------------------SQLDMED------------ 200

  Fly   242 FVAPEAVLGTDDSSSSSSESSGEDSDHSLPDIEPEERYAEIPKRVVVKPKKYRKREKPLVPPVRL 306
                  ||
  Fly   201 ------VL--------------------------------------------------------- 202

  Fly   307 SREEIERRKLQQDEYDEIILQFFKKFPCSLCNLLVQNFADMRRHQRVSHNIESGYIECCGRKFHL 371
              :|:.:.:|.|...|.      ...|.|:.|                 :::|..::.|
  Fly   203 --DELPQEELSQPRLDS------TTSPASMEN-----------------DVKSEMLDSC------ 236

  Fly   372 RKALAEHVLVHKNPDHFMCSQCGRVFQDSRALEVHEQTHTNP---EVKAEPKEKR-IYQCEKCPK 432
                       :..|.|:.       .|.:.::: ....|.|   |..||.|.|| ...||||.|
  Fly   237 -----------EGDDDFLP-------VDGQLMDL-VAVATTPNTLESTAEEKAKRGRMDCEKCGK 282

  Fly   433 SFTTKAAMEYH------DVSKHVPKSEFKYSCPECNKKIPTERKLKEHLRYMHDPEAAIICDKCG 491
            .:..:|:.|.|      .:.:.|...:...:|..|||.:.:...||.|...:|......|||.||
  Fly   283 VYRNRASYEKHLERECRRIERRVKVDKTTTTCDICNKTLSSATALKLHKEGIHQNVKPYICDSCG 347

  Fly   492 KTLRSQTNLKKHHELEHSEKPRPKPDPVQCEICGTWLRHLSGLKQHMKTVHEPPGDEHRCHICNK 556
            |.|::.|.|.: |:|.|:|.     .|.:|.:|....::.:.||.|.: :|..|  ...|:||.|
  Fly   348 KQLKTITALNE-HKLVHTES-----RPFECTVCKAGFKNRARLKAHYQ-IHAEP--SFVCNICGK 403

  Fly   557 TSTNSRALKRH-IYHNHLCERKFKCGMCEKAFKRPQDLREHTSTHTGEVLYTCPNCPMTFFSNAN 620
            .....|....| :.|..  ||:.||.:|...|||.:.|:.|..:|||...|.|..|..:|..|||
  Fly   404 KLQTRRTWNMHKVVHTE--ERRLKCDVCGALFKRSKTLKTHLLSHTGLRPYVCNYCGKSFACNAN 466

  Fly   621 MYKHRQRLHRAEWEADRKKPLPPNI------------MKISQGAT 653
            ...|:.:.|..|.:.:....||..:            .|:.:|.|
  Fly   467 CRSHKLKKHPQEVQQEDGARLPSRLNVPTLDELRVMTQKLPKGTT 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4707	NP_611944.1	zf-AD	3..73	CDD:285071	17/79 (22%)
		C2H2 Zn finger	334..355	CDD:275368	2/20 (10%)
		LIM	<361..407	CDD:295319	4/45 (9%)
		C2H2 Zn finger	365..382	CDD:275368	1/16 (6%)
		C2H2 Zn finger	390..410	CDD:275368	1/19 (5%)
		C2H2 Zn finger	427..443	CDD:275368	7/15 (47%)
		C2H2 Zn finger	458..476	CDD:275368	7/17 (41%)
		C2H2 Zn finger	487..507	CDD:275368	9/19 (47%)
		C2H2 Zn finger	521..540	CDD:275368	5/18 (28%)
		C2H2 Zn finger	551..572	CDD:275368	7/21 (33%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
		C2H2 Zn finger	608..629	CDD:275368	7/20 (35%)
CG17568	NP_609951.2	zf-AD	10..87	CDD:214871	17/75 (23%)
		COG5048	<313..471	CDD:227381	56/168 (33%)
		C2H2 Zn finger	314..335	CDD:275368	7/20 (35%)
		C2H2 Zn finger	343..363	CDD:275368	10/20 (50%)
		C2H2 Zn finger	371..391	CDD:275368	5/20 (25%)
		C2H2 Zn finger	398..418	CDD:275368	6/19 (32%)
		C2H2 Zn finger	426..446	CDD:275368	7/19 (37%)
		zf-H2C2_2	439..463	CDD:290200	9/23 (39%)
		C2H2 Zn finger	454..475	CDD:275368	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471736
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840