DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4707 and CG11695

DIOPT Version :9

Sequence 1:	NP_611944.1	Gene:	CG4707 / 37935	FlyBaseID:	FBgn0035036	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	676	Identity:	171/676 - (25%)
Similarity:	262/676 - (38%)	Gaps:	169/676 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VCVLCLDSSNAGYGL--QSEEG---VRLNIRATIHKHFAFSEVLTAGGDAEVCRECWNCVSSFEE 62
            :|.||||.:.....:  |.:.|   |..|:...|.||.....:...|....:|.:||..::.||:
  Fly     2 ICRLCLDDAEHSVPIFDQDDSGDQPVPSNLAELIEKHLQLVLLPNDGVSKSLCTQCWQQLADFEQ 66

  Fly    63 FHQRVSCLHRQRS-SDSKSEPIEFCGQTEEAIINPLYSVELDALAEAFFAPSEVKVEVNELEPLP 126
            |...|  :.:|.. ...|.||               :|.:.||..
  Fly    67 FCAMV--MKKQLGLQQLKMEP---------------FSEDEDADT-------------------- 94

  Fly   127 KVELLEDPVKTEIRTAPKRLGVPNEGSPHSKRRIKNELPVDSDSDAPLADFLNSDSKRSSVGPAK 191
            |.::|.:|   ||..:|  ....||..        ||:    |.||      :|:|:.||:....
  Fly    95 KAQILCEP---EIDVSP--AAADNEEC--------NEI----DGDA------SSNSRSSSIRTTS 136

  Fly   192 NSEANKGRQLRRSARRGRPPKAKPESAPSPKKELDSEDGEENARDNNDMEFVAPEAVLGTDDSSS 256
            ..|......:||..|..|...|....|...|....:...|  |.::.|.|        |..|..|
  Fly   137 LREMRLPSPIRRRMRLPRAVTAPKTQAVKAKARTKTHKAE--ADEDEDAE--------GEGDPES 191

  Fly   257 SSSESSGEDSDHSLPDIEPEERYAEIPKRVVVKPKKYRKREKPLVPPVRLSREEIERRKLQQDEY 321
            .||.|.                                                      :.|.|
  Fly   192 RSSNSR------------------------------------------------------EMDSY 202

  Fly   322 DEIILQFFKKFPCSLCNLLVQ--NFADMRRHQRVSHNIESGYIECCGRKFHLRKALAEHVLVHKN 384
                :....:..|.:|....|  |||:|:||.| :|:...||:.||.|::..|....:|:.:|.:
  Fly   203 ----IALHGRLECCICGGDEQFPNFAEMKRHFR-NHHQSLGYVVCCQRRYKKRALYVDHLHMHND 262

  Fly   385 PDHFMCSQCGRVFQDSRALEVHE-QTHTNPEVKAEPKEKRIYQCEKCPKSFTTKAAMEYHDVSKH 448
            |::|.|..|.:......:.:||. :.|.|       |:...:.|::|.|.|:.:..:..|   ..
  Fly   263 PNYFRCKICSKQLVSRISYDVHMLRFHPN-------KDDLSFACDQCSKRFSKQFLLTIH---SR 317

  Fly   449 VPKSEFKYSCPECNKKIPTERKLKEHLRYMHDPE-AAIICDKCGKTLRSQTNLKKHHELEHSEKP 512
            |.:.|....|..|::...|...|:.|:|..|||. ...|||.||...:::.||..|....|.|..
  Fly   318 VHQQERNEQCKHCDRSFRTAVDLRLHMRRTHDPAFVPFICDSCGAKFKTKQNLLVHKRTVHREGS 382

  Fly   513 RPKPDPVQCEICGTWLRHLSGLKQHMKTVHEPPGD--EHRCHICNKTSTNSRALKRHIYHNHLCE 575
            : .|: |||:.|..||...:.|::|| .:|.....  :.:|..|.....:...|..||.::|..|
  Fly   383 Q-LPE-VQCQECQVWLSDENSLRKHM-YMHLDAASLRQWKCEQCGLEKGSRAKLAAHIRYHHPKE 444

  Fly   576 RKFKCGMCEKAFKRPQDLREHTSTHTGEVLYTCPNCPMTFFSNANMYKHRQRLHRAEWEA-DRKK 639
             ..||..|.|.||..:.|.|||:||||:.||.|..|..||.::.||:|||:::|.|:..| .::|
  Fly   445 -YHKCTHCAKEFKSSRSLEEHTATHTGQDLYECAFCERTFKNSGNMHKHRRQMHAAQVAALQQQK 508

  Fly   640 PLPPNIMKISQGATTAMKKRQTSGAL 665
            .:||:             ||:..|.|
  Fly   509 KVPPS-------------KRKDKGDL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4707	NP_611944.1	zf-AD	3..73	CDD:285071	20/74 (27%)
		C2H2 Zn finger	334..355	CDD:275368	10/22 (45%)
		LIM	<361..407	CDD:295319	12/45 (27%)
		C2H2 Zn finger	365..382	CDD:275368	4/16 (25%)
		C2H2 Zn finger	390..410	CDD:275368	4/20 (20%)
		C2H2 Zn finger	427..443	CDD:275368	4/15 (27%)
		C2H2 Zn finger	458..476	CDD:275368	5/17 (29%)
		C2H2 Zn finger	487..507	CDD:275368	7/19 (37%)
		C2H2 Zn finger	521..540	CDD:275368	7/18 (39%)
		C2H2 Zn finger	551..572	CDD:275368	5/20 (25%)
		C2H2 Zn finger	580..600	CDD:275368	9/19 (47%)
		C2H2 Zn finger	608..629	CDD:275368	9/20 (45%)
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071	21/80 (26%)
		C2H2 Zn finger	268..289	CDD:275368	4/20 (20%)
		C2H2 Zn finger	299..319	CDD:275368	5/22 (23%)
		C2H2 Zn finger	327..348	CDD:275368	6/20 (30%)
		C2H2 Zn finger	357..376	CDD:275368	7/18 (39%)
		C2H2 Zn finger	389..409	CDD:275368	7/20 (35%)
		C2H2 Zn finger	420..440	CDD:275368	5/19 (26%)
		C2H2 Zn finger	448..468	CDD:275368	9/19 (47%)
		C2H2 Zn finger	476..494	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134721
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910