DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13587 and CLEC4M

DIOPT Version :9

Sequence 1:	NP_611939.1	Gene:	CG13587 / 37930	FlyBaseID:	FBgn0035031	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_055072.3	Gene:	CLEC4M / 10332	HGNCID:	13523	Length:	399	Species:	Homo sapiens

Alignment Length:	280	Identity:	63/280 - (22%)
Similarity:	96/280 - (34%)	Gaps:	80/280 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KLNPLQFHLVRQCQRAAADEALALENTSSLKECADLAHDMRGLALNYAPGGPKRRLNAFDQR--- 88
            ||..:...|.|  .:||..|   |...|.|:|......:::. |:...|  .|.:|....|.
Human   177 KLQEIYQELTR--LKAAVGE---LPEKSKLQEIYQELTELKA-AVGELP--EKSKLQEIYQELTQ 233

  Fly    89 ---SFGKQGD--KEQRIRSRLSVFEQPGEFFNCHVLKCPQNNT-FSG----MVNDSRFDYYSLYG 143
               :.|:..|  |:|:|...|:..:...|....|   ||::.| |.|    |.|..|..:.|:..
Human   234 LKAAVGELPDQSKQQQIYQELTDLKTAFERLCRH---CPKDWTFFQGNCYFMSNSQRNWHDSVTA 295

  Fly   144 RPTVVRNYSCIPEVGLFVVYT-QPSAYLNASLTCSNSSEFTGSLAHIASEHRTSLLAQWLVEFNR 207
            ...|        ...|.|:.| :...:|....:.||...:.| |:.:..|...    ||:
Human   296 CQEV--------RAQLVVIKTAEEQNFLQLQTSRSNRFSWMG-LSDLNQEGTW----QWV----- 342

  Fly   208 KSQSLAEGNVYLAYVGLAYNSSTSLSPLDFRNSQGESLQCFLYRAWDGGHPRVGGDLGNASCVAL 272
                                ..:.|||         |.|    |.|:.|.|   .:.||..|...
Human   343 --------------------DGSPLSP---------SFQ----RYWNSGEP---NNSGNEDCAEF 371

  Fly   273 TPQGTWQTLNCDRELPFICE 292
            :..| |....||.:..:||:
Human   372 SGSG-WNDNRCDVDNYWICK 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13587	NP_611939.1	CLECT	160..293	CDD:153057	28/134 (21%)
CLEC4M	NP_055072.3	Endocytosis signal. /evidence=ECO:0000250	14..15
		transmembrane domain	44..71
		7 X approximate tandem repeats	108..269		24/102 (24%)
		DUF342	<140..251	CDD:302792	20/81 (25%)
		CLECT_DC-SIGN_like	268..391	CDD:153060	39/178 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000