DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Start1 and Stard3

DIOPT Version :9

Sequence 1:	NP_001246495.1	Gene:	Start1 / 37927	FlyBaseID:	FBgn0035028	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001014251.1	Gene:	Stard3 / 363675	RGDID:	1549768	Length:	446	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	148/554 - (26%)
Similarity:	238/554 - (42%)	Gaps:	152/554 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SRAHSINLITEDFLAGYMQDGR-MSVVRRFFCLFVTFDLVFVSLLWLICIVINGDNIFTAFHKQI 97
            |.:||.:| :..|:...::..| :|.|||.|||||||||:|:||||:|.:..| ..|.....:::
  Rat    25 SLSHSQSL-SSHFIPPPLEKRRVVSDVRRTFCLFVTFDLLFISLLWIIELNTN-TGIRKNLEQEV 87

  Fly    98 VEYTIYKSLFDVVAVAICRFLVLIFFYAILYINHWSIIALSTSGSCLFLISKVFVFDWLDSKQQV 162
            :.|:...|.||:..:|..||..|:..||:|.:.||.:||::|..|..|||.||.:.:.|  .:..
  Rat    88 IHYSFQSSFFDIFVLAFFRFSGLLLGYAVLRLQHWWVIAITTLVSSAFLIVKVILSELL--SKGA 150

  Fly   163 FEVILIITSFILAWGEAWFLDCRVIPQERHAQH-YFRTMTSNDRTPMEQPAILIEQE--RPPQSV 224
            |..:|.|.||:|||.|.||||.:|:|||...:. |.....:..|.|:.....|.|.:  .||:|.
  Rat   151 FGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQAAVARGPLLFSGALSEGQFYSPPESF 215

  Fly   225 TDFYSLMDTARHSDEE-------DELDDEYTQMGLDCLRKAYEII-ESSDWKVEKVNQKGDTIHS 281
            ....|      .||||       ...:.||.:.|.:......:|: :..:||:|:.|:.|||:::
  Rat   216 AGSDS------ESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKLERRNEYGDTVYT 274

  Fly   282 TQRDKIGKIYKLTARIKYPAKALMEDLFYRIEDCPKWNPALLESKIVRKINSYTDITYQVSVGGG 346
            .:....||.:.|...:..||:.:.:::..:.|....||..:...:|::::...|.::|.||.|..
  Rat   275 IEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLVSYDVSSGAA 339

  Fly   347 GGMVKSRDFVNLRSCRLFYNGQICDDDETAQLSSDDGNSSLNRSCEGSVSTISDGDSNTPLLPSS 411
            ||:|..|||||:|
  Rat   340 GGVVSPRDFVNVR---------------------------------------------------- 352

  Fly   412 VSSCKATFPTSSKGAAMPFDTLGNSLGAKSLGPIVNFDEEPPPLDQDEFEDAKDKVDGEANNMTK 476

  Rat   353 ----------------------------------------------------------------- 352

  Fly   477 PNVPSVGKTKDRVWVTSAVSVQYAAVPPSPKYTRGQNIVSGFAFREIVGKSDS----CIVEWVLC 537
                .:.:.:|| :::|.::..:.:.||:.||.||:|...||    ||.||.|    |...|:|.
  Rat   353 ----RIERRRDR-YLSSGIATTHCSKPPTHKYVRGENGPGGF----IVLKSASNPRVCTFVWILN 408

  Fly   538 LDLKGYIPRYVLDAALTSSMTDYISNLRKHVNEL 571
            .||||.:|||::..:|.::|.::...||:.|.||
  Rat   409 TDLKGRLPRYLIHQSLGATMFEFAFYLRQRVGEL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Start1	NP_001246495.1	MENTAL	57..232	CDD:287435	70/177 (40%)
Start1	NP_001246495.1	SRPBCC	247..571	CDD:301327	65/328 (20%)
Stard3	NP_001014251.1	MENTAL	48..213	CDD:287435	67/167 (40%)
Stard3	NP_001014251.1	START_STARD3-like	234..442	CDD:176915	66/333 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335621
Domainoid	1	1.000	123	1.000	Domainoid score	I5457
eggNOG	1	0.900	-	-		E1_KOG3845
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38227
Inparanoid	1	1.050	175	1.000	Inparanoid score	I3963
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1437203at2759
OrthoFinder	1	1.000	-	-		FOG0001150
OrthoInspector	1	1.000	-	-		otm45043
orthoMCL	1	0.900	-	-		OOG6_106748
Panther	1	1.100	-	-	LDO	PTHR46121
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4583
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800