DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Start1 and STARD6

DIOPT Version :9

Sequence 1:	NP_001246495.1	Gene:	Start1 / 37927	FlyBaseID:	FBgn0035028	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001381308.1	Gene:	STARD6 / 147323	HGNCID:	18066	Length:	231	Species:	Homo sapiens

Alignment Length:	344	Identity:	57/344 - (16%)
Similarity:	105/344 - (30%)	Gaps:	157/344 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 AYEII----ESSDWKVEKVN----------QKGDTIHSTQRDKI-GKIYKLTARI-KYPAKALME 306
            |.|::    ::|.|||.|.:          :|..|:.|....|. |.:|::...| :.|||  :.
Human    11 AQEVLGYNRDTSGWKVVKTSLIICGFLFPFEKKITVSSKASRKFHGNLYRVEGIIPESPAK--LS 73

  Fly   307 DLFYRIEDCPKWNPALLESKIVRKINSYTDITYQVSVGGGGGMVKSRDFVNLRSCRLFYNGQICD 371
            |..|:..|...|:.:|....:|.:|:|.|.|.:.::.....|.:..|||::|...:.:
Human    74 DFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFIDLVYIKRY------- 131

  Fly   372 DDETAQLSSDDGNSSLNRSCEGSVSTISDGDSNTPLLPSSVSSCKATFPTSSKGAAMPFDTLGNS 436
                                ||:::.|                       |||
Human   132 --------------------EGNMNII-----------------------SSK------------ 141

  Fly   437 LGAKSLGPIVNFDEEPPPLDQDEFEDAKDKVDGEANNMTKPNVPSVGKTKDRVWVTSAVSVQYAA 501
                                                                       ||.:..
Human   142 -----------------------------------------------------------SVDFPE 147

  Fly   502 VPPSPKYTRGQNIVSGF---------AFREIVGKSDSCIVEWVLCLDLKGYIPRYVLDAALTSSM 557
            .|||..|.||.|...||         |:.::|         ..:..:::|.:...:::..:.|::
Human   148 YPPSSNYIRGYNHPCGFVCSPMEENPAYSKLV---------MFVQTEMRGKLSPSIIEKTMPSNL 203

  Fly   558 TDYISNLRKHVNELRQKGR 576
            .::|.|.:..:...|...|
Human   204 VNFILNAKDGIKAHRTPSR 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Start1	NP_001246495.1	MENTAL	57..232	CDD:287435
Start1	NP_001246495.1	SRPBCC	247..571	CDD:301327	55/337 (16%)
STARD6	NP_001381308.1	START_STARD6-like	1..215	CDD:176913	55/335 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141907
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740