Protein Alignment Start1 and STARD3

DIOPT Version :9

• Sequence 1: NP_001246495.1
• Gene: Start1 / 37927
• FlyBaseID: FBgn0035028
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001159409.1
• Gene: STARD3 / 10948
• HGNCID: 17579
• Length: 445
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 128/546 - (23%)
• Similarity: 210/546 - (38%)
• Gaps: 180/546 - (32%)

  Fly    56 MSVVRRFFCLFVTFDLVFVSLLWLICIVINGDNIFTAFHKQIVEYTIYKSLFDVVAVAICRFLVL 120
            :|.|||.|||||||||:|:||||:|.:..| ..|.....::|::|....|.||:..:|..||..|
Human    46 ISDVRRTFCLFVTFDLLFISLLWIIELNTN-TGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGL 109

  Fly   121 IFFYAILYINHW--------SIIALSTSGSCLFLISKVFVFDWLDSKQQVFEVILIITSFILAWG 177
            :..||:|.:.||        |.::.|:|.||             .:|..    :...:...|...
Human   110 LLGYAVLRLRHWSRRWCPVHSSLSRSSSLSC-------------SAKGH----LATCSPSSLLSS 157

  Fly   178 EAWFLDCRVIPQERHAQHYFRTMTSNDRTPMEQPAILIEQERPP------QSVTDFYSLMDTARH 236
            ..|      .|....::.|.|.:..:|..|....|..:...|.|      .|...|||..::...
Human   158 PGW------RPGSLTSKSYPRKLKRSDSAPPGYLAAQVAVARGPLLFSGALSEGQFYSPPESFAG 216

  Fly   237 SDEEDE-----------LDDEYTQMGLDCLRKAYEII-ESSDWKVEKVNQKGDTIHSTQRDKIGK 289
            ||.|.:           .:.||.:.|.:......:|: :..:||.||.|:.|||:::.:....||
Human   217 SDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGK 281

  Fly   290 IYKLTARIKYPAKALMEDLFYRIEDCPKWNPALLESKIVRKINSYTDITYQVSVGGGGGMVKSRD 354
            .:.|...:..||:.:.:::..:.|....||..:...:|::::...|.|:|.||.|..||:|..||
Human   282 TFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRD 346

  Fly   355 FVNLRSCRLFYNGQICDDDETAQLSSDDGNSSLNRSCEGSVSTISDGDSNTPLLPSSVSSCKATF 419
            |||:|
Human   347 FVNVR------------------------------------------------------------ 351

  Fly   420 PTSSKGAAMPFDTLGNSLGAKSLGPIVNFDEEPPPLDQDEFEDAKDKVDGEANNMTKPNVPSVGK 484
                                                                         .:.:
Human   352 -------------------------------------------------------------RIER 355

  Fly   485 TKDRVWVTSAVSVQYAAVPPSPKYTRGQNIVSGFAFREIVGKSDS----CIVEWVLCLDLKGYIP 545
            .:|| :::|.::..::|.||:.||.||:|...||    ||.||.|    |...|:|..||||.:|
Human   356 RRDR-YLSSGIATSHSAKPPTHKYVRGENGPGGF----IVLKSASNPRVCTFVWILNTDLKGRLP 415

  Fly   546 RYVLDAALTSSMTDYISNLRKHVNEL 571
            ||::..:|.::|.::..:||:.::||
Human   416 RYLIHQSLAATMFEFAFHLRQRISEL 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Start1	NP_001246495.1	MENTAL	57..232	CDD:287435	55/188 (29%)
		SRPBCC	247..571	CDD:301327	67/328 (20%)
STARD3	NP_001159409.1	MENTAL	47..212	CDD:287435	55/188 (29%)
		START_STARD3-like	233..441	CDD:176915	68/333 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141902
Domainoid	1	1.000	124	1.000	Domainoid score	I5530
eggNOG	1	0.900	-	-		E1_KOG3845
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38227
Inparanoid	1	1.050	176	1.000	Inparanoid score	I4052
Isobase	1	0.950	-	0	Normalized mean entropy	S6681
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1437203at2759
OrthoFinder	1	1.000	-	-		FOG0001150
OrthoInspector	1	1.000	-	-		otm40906
orthoMCL	1	0.900	-	-		OOG6_106748
Panther	1	1.100	-	-	LDO	PTHR46121
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4583
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.710