DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3511 and PPIL2

DIOPT Version :9

Sequence 1:	NP_001286847.1	Gene:	CG3511 / 37926	FlyBaseID:	FBgn0035027	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	XP_011528343.1	Gene:	PPIL2 / 23759	HGNCID:	9261	Length:	616	Species:	Homo sapiens

Alignment Length:	339	Identity:	110/339 - (32%)
Similarity:	164/339 - (48%)	Gaps:	78/339 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 NATLNILFDSTGNFLLYPTM--LGIKVIN---VVTNR------CVTILGKTDNIRPLQVALFQGR 401
            |.|..:...:|||...|..:  |.||..|   ::|:.      .:|:...| |:....|:.|. .
Human   112 NNTHIVAVRTTGNVYAYEAVEQLNIKAKNFRDLLTDEPFSRQDIITLQDPT-NLDKFNVSNFY-H 174

  Fly   402 IKRQKAAITMEQEASENPALQNILNDPTAFCTAYKKSRFYLYSRRLPSDLQDVDRDIFNEKPSKE 466
            :|.....|..::|.::        .||:          :||  :...::.::..::::.|....|
Human   175 VKNNMKIIDPDEEKAK--------QDPS----------YYL--KNTNAETRETLQELYKEFKGDE 219

  Fly   467 DIIA---VPEASVVQR------------------------------IYENVV------------L 486
            .:.|   .||...|.:                              |.|:|:            |
Human   220 ILAATMKAPEKKKVDKLNAAHYSTGKVSASFTSTAMVPETTHEAAAIDEDVLRYQFVKKKGYVRL 284

  Fly   487 HTTKGDIHMRLFFKEVPKTVENFCVHAKNGYYNGHIFHRVIKGFMVQTGDPTGTGTGGKSIWGSD 551
            ||.|||:::.|.....|||.|||....|..||:|.||||.|:.|::|.||||||||||:|.||..
Human   285 HTNKGDLNLELHCDLTPKTCENFIRLCKKHYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKP 349

  Fly   552 FKDEFVPSLKHDRPYTVSMANAGPNTNGSQFFITVLPTPWLDNKHTVFGRVYRGMEVVLNICNSK 616
            |||||.|:|.|.....:||||:|||:|.||||||.....:||.|||:||||..|.:|:..:.|.:
Human   350 FKDEFRPNLSHTGRGILSMANSGPNSNRSQFFITFRSCAYLDKKHTIFGRVVGGFDVLTAMENVE 414

  Fly   617 ANPKTDKPYDDIKI 630
            ::||||:|.::|:|
Human   415 SDPKTDRPKEEIRI 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3511	NP_001286847.1	WD40	<75..>312	CDD:225201
		WD40	<79..300	CDD:295369
		WD40 repeat	85..122	CDD:293791
		WD40 repeat	128..176	CDD:293791
		WD40 repeat	181..210	CDD:293791
		WD40 repeat	218..268	CDD:293791
		WD40 repeat	275..311	CDD:293791
		cyclophilin_WD40	485..633	CDD:238908	78/158 (49%)
PPIL2	XP_011528343.1	RING-Ubox_PPIL2	38..110	CDD:319577
		RING_Ubox	100..159	CDD:388418	12/46 (26%)
		U-box domain, a modified RING finger	103..146	CDD:319361	10/33 (30%)
		cyclophilin_RING	281..440	CDD:238904	78/148 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1392223at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920