DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3511 and cyn-15

DIOPT Version :9

Sequence 1:	NP_001286847.1	Gene:	CG3511 / 37926	FlyBaseID:	FBgn0035027	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_493378.1	Gene:	cyn-15 / 173225	WormBaseID:	WBGene00000891	Length:	629	Species:	Caenorhabditis elegans

Alignment Length:	642	Identity:	273/642 - (42%)
Similarity:	406/642 - (63%)	Gaps:	41/642 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EENEPQEESVSSEKEAEGEEDAWIGPMPSEQSAPAPAKKKKVLPYEHIYLENLPNAESYERSYMH 80
            :|..|:::.|.:               |.|.:..||  ||..|.:|..:|.::|::..||:|:||
Worm     6 KEPSPKKKRVEN---------------PPENAPDAP--KKPQLKHESEFLRSIPSSSQYEKSFMH 53

  Fly    81 RDVITHLVCTKTDFVVTASLDGHIKFWKKGEL-GIEFVKHFRSHLVPIKSLTTNDSGTLL---CS 141
            ||.|:|::.|||||::|||:|||:|||||... |:|||||||.||.....:..|..||||   |.
Worm    54 RDTISHVIATKTDFIITASVDGHLKFWKKKHSEGVEFVKHFRCHLSEFSHICANIDGTLLATVCE 118

  Fly   142 AATDQTAKVFDVVNFDMINIIRLGYTPQCSEWINGPGDAVQALAISDSESSRIHIYDGQGGGEAL 206
            |  |::.||||:.||||||:|:|.:.|:.:.|::...|.:..|||..::|.:|.:.||:.....:
Worm   119 A--DKSVKVFDIENFDMINMIKLDFPPKTANWVHQSNDPIAHLAIGAADSGKIIVVDGKATAAPI 181

  Fly   207 HTLEKLHSAPVVAMCLNVAMETVISVDRNGILEYWQNSKYDYKFPQRLVNFDSKLDTSLFEFAKQ 271
            ...:||||.||..:..:.:::.::|:|.:|::|.|...:.|::||:..:.::.||:|.|::|.|.
Worm   182 CIKDKLHSTPVKIIEYSQSLDIIVSIDESGMIECWNGERGDFQFPETKLTWEYKLETDLYDFVKA 246

  Fly   272 KTQVTGLAATPDGKRFAAISTDRKVRVFQFNTGKLIRVFDEALSTY-TQMQQTK-HALPNMEFGR 334
            ||........|.|.:.|..:.|||:|:|...||||.::.||....| .:.::.| :.|.:||:.|
Worm   247 KTIPVCATFDPSGLKLATFAEDRKIRIFNVKTGKLAQLIDETTQKYHCEAKENKNYGLQHMEWSR 311

  Fly   335 RMAAERDLEKTAQNAT--LNILFDSTGNFLLYPTMLGIKVINVVTNRCVTILGKTDNIRPLQVAL 397
            |:|:|::::|..:|:.  ..|.||.:||||||||.:|:||.|:|||.....:|:.:.||.:.|:|
Worm   312 RLASEKEMDKDKKNSLKYTKICFDQSGNFLLYPTPIGVKVFNLVTNEVSRTIGRDEAIRFVAVSL 376

  Fly   398 FQG----RIKRQKAAITMEQEASENPALQNILN-DPTAFCTAYKKSRFYLYSRRLPSDLQDVD-- 455
            ...    |.|.|.||||:|..|::||.|....: ||...|.|.:|:||||::...|.:::|.:
Worm   377 CNALPDIRQKLQGAAITLETAAADNPTLNRKTDPDPLMVCCALRKNRFYLFTNTEPYNVEDDEGN 441

  Fly   456 -----RDIFNEKPSKEDIIAVPEASVVQRIY-ENVVLHTTKGDIHMRLFFKEVPKTVENFCVHAK 514
                 ||:|||:|.|||::...:....:::. :..::||:.|||.:|||..|.||||||||.|::
Worm   442 PSVSGRDVFNERPKKEDLLTALDTEGGEKVLNKEAIIHTSFGDITIRLFGDECPKTVENFCTHSR 506

  Fly   515 NGYYNGHIFHRVIKGFMVQTGDPTGTGTGGKSIWGSDFKDEFVPSLKHDRPYTVSMANA-GPNTN 578
            .|||||..||||||.||:|||||:|.||||:||||.||:|||.|.|:||:|:.|||||| |.|||
Worm   507 RGYYNGLTFHRVIKSFMIQTGDPSGKGTGGESIWGEDFEDEFHPRLRHDKPFKVSMANAGGGNTN 571

  Fly   579 GSQFFITVLPTPWLDNKHTVFGRVYRGMEVVLNICNSKANPKTDKPYDDIKIISIHL 635
            ||||||||.|..|||.|:|:||.|..||.||..|.......::.:|.:.|:|:||.|
Worm   572 GSQFFITVCPADWLDGKNTLFGEVTAGMSVVQRINQVSTFERSGRPRESIQIMSISL 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3511	NP_001286847.1	WD40	<75..>312	CDD:225201	98/240 (41%)
		WD40	<79..300	CDD:295369	91/224 (41%)
		WD40 repeat	85..122	CDD:293791	24/37 (65%)
		WD40 repeat	128..176	CDD:293791	22/50 (44%)
		WD40 repeat	181..210	CDD:293791	7/28 (25%)
		WD40 repeat	218..268	CDD:293791	12/49 (24%)
		WD40 repeat	275..311	CDD:293791	12/35 (34%)
		cyclophilin_WD40	485..633	CDD:238908	90/148 (61%)
cyn-15	NP_493378.1	WD40	53..>285	CDD:392136	95/233 (41%)
		WD40 repeat	101..142	CDD:293791	20/42 (48%)
		WD40 repeat	150..185	CDD:293791	8/34 (24%)
		WD40 repeat	192..237	CDD:293791	10/44 (23%)
		cyclophilin	477..626	CDD:381853	90/148 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156178
Domainoid	1	1.000	232	1.000	Domainoid score	I1368
eggNOG	1	0.900	-	-		E1_KOG0882
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9099
Inparanoid	1	1.050	527	1.000	Inparanoid score	I669
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54581
OrthoDB	1	1.010	-	-		D1392223at2759
OrthoFinder	1	1.000	-	-		FOG0005501
OrthoInspector	1	1.000	-	-		oto20739
orthoMCL	1	0.900	-	-		OOG6_102016
Panther	1	1.100	-	-	LDO	PTHR45625
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4358
SonicParanoid	1	1.000	-	-		X3351
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840