DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3511 and cyn-15

DIOPT Version :10

Sequence 1:NP_611935.1 Gene:CG3511 / 37926 FlyBaseID:FBgn0035027 Length:637 Species:Drosophila melanogaster
Sequence 2:NP_493378.1 Gene:cyn-15 / 173225 WormBaseID:WBGene00000891 Length:629 Species:Caenorhabditis elegans


Alignment Length:642 Identity:273/642 - (42%)
Similarity:406/642 - (63%) Gaps:41/642 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 EENEPQEESVSSEKEAEGEEDAWIGPMPSEQSAPAPAKKKKVLPYEHIYLENLPNAESYERSYMH 80
            :|..|:::.|.:               |.|.:..||  ||..|.:|..:|.::|::..||:|:||
 Worm     6 KEPSPKKKRVEN---------------PPENAPDAP--KKPQLKHESEFLRSIPSSSQYEKSFMH 53

  Fly    81 RDVITHLVCTKTDFVVTASLDGHIKFWKKGEL-GIEFVKHFRSHLVPIKSLTTNDSGTLL---CS 141
            ||.|:|::.|||||::|||:|||:|||||... |:|||||||.||.....:..|..||||   |.
 Worm    54 RDTISHVIATKTDFIITASVDGHLKFWKKKHSEGVEFVKHFRCHLSEFSHICANIDGTLLATVCE 118

  Fly   142 AATDQTAKVFDVVNFDMINIIRLGYTPQCSEWINGPGDAVQALAISDSESSRIHIYDGQGGGEAL 206
            |  |::.||||:.||||||:|:|.:.|:.:.|::...|.:..|||..::|.:|.:.||:.....:
 Worm   119 A--DKSVKVFDIENFDMINMIKLDFPPKTANWVHQSNDPIAHLAIGAADSGKIIVVDGKATAAPI 181

  Fly   207 HTLEKLHSAPVVAMCLNVAMETVISVDRNGILEYWQNSKYDYKFPQRLVNFDSKLDTSLFEFAKQ 271
            ...:||||.||..:..:.:::.::|:|.:|::|.|...:.|::||:..:.::.||:|.|::|.|.
 Worm   182 CIKDKLHSTPVKIIEYSQSLDIIVSIDESGMIECWNGERGDFQFPETKLTWEYKLETDLYDFVKA 246

  Fly   272 KTQVTGLAATPDGKRFAAISTDRKVRVFQFNTGKLIRVFDEALSTY-TQMQQTK-HALPNMEFGR 334
            ||........|.|.:.|..:.|||:|:|...||||.::.||....| .:.::.| :.|.:||:.|
 Worm   247 KTIPVCATFDPSGLKLATFAEDRKIRIFNVKTGKLAQLIDETTQKYHCEAKENKNYGLQHMEWSR 311

  Fly   335 RMAAERDLEKTAQNAT--LNILFDSTGNFLLYPTMLGIKVINVVTNRCVTILGKTDNIRPLQVAL 397
            |:|:|::::|..:|:.  ..|.||.:||||||||.:|:||.|:|||.....:|:.:.||.:.|:|
 Worm   312 RLASEKEMDKDKKNSLKYTKICFDQSGNFLLYPTPIGVKVFNLVTNEVSRTIGRDEAIRFVAVSL 376

  Fly   398 FQG----RIKRQKAAITMEQEASENPALQNILN-DPTAFCTAYKKSRFYLYSRRLPSDLQDVD-- 455
            ...    |.|.|.||||:|..|::||.|....: ||...|.|.:|:||||::...|.:::|.:  
 Worm   377 CNALPDIRQKLQGAAITLETAAADNPTLNRKTDPDPLMVCCALRKNRFYLFTNTEPYNVEDDEGN 441

  Fly   456 -----RDIFNEKPSKEDIIAVPEASVVQRIY-ENVVLHTTKGDIHMRLFFKEVPKTVENFCVHAK 514
                 ||:|||:|.|||::...:....:::. :..::||:.|||.:|||..|.||||||||.|::
 Worm   442 PSVSGRDVFNERPKKEDLLTALDTEGGEKVLNKEAIIHTSFGDITIRLFGDECPKTVENFCTHSR 506

  Fly   515 NGYYNGHIFHRVIKGFMVQTGDPTGTGTGGKSIWGSDFKDEFVPSLKHDRPYTVSMANA-GPNTN 578
            .|||||..||||||.||:|||||:|.||||:||||.||:|||.|.|:||:|:.|||||| |.|||
 Worm   507 RGYYNGLTFHRVIKSFMIQTGDPSGKGTGGESIWGEDFEDEFHPRLRHDKPFKVSMANAGGGNTN 571

  Fly   579 GSQFFITVLPTPWLDNKHTVFGRVYRGMEVVLNICNSKANPKTDKPYDDIKIISIHL 635
            ||||||||.|..|||.|:|:||.|..||.||..|.......::.:|.:.|:|:||.|
 Worm   572 GSQFFITVCPADWLDGKNTLFGEVTAGMSVVQRINQVSTFERSGRPRESIQIMSISL 628

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3511NP_611935.1 WD40 repeat 85..122 CDD:293791 24/37 (65%)
WD40 <94..310 CDD:441893 86/219 (39%)
WD40 repeat 128..176 CDD:293791 22/50 (44%)
WD40 repeat 181..210 CDD:293791 7/28 (25%)
WD40 repeat 218..268 CDD:293791 12/49 (24%)
WD40 repeat 275..311 CDD:293791 12/35 (34%)
cyclophilin_WD40 485..633 CDD:238908 90/148 (61%)
cyn-15NP_493378.1 WD40 53..>285 CDD:475233 95/233 (41%)
WD40 repeat 101..142 CDD:293791 20/42 (48%)
WD40 repeat 150..185 CDD:293791 8/34 (24%)
WD40 repeat 192..237 CDD:293791 10/44 (23%)
cyclophilin 477..626 CDD:469651 90/148 (61%)

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