DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fcp1 and CTDP1

DIOPT Version :9

Sequence 1:	NP_001286846.1	Gene:	Fcp1 / 37925	FlyBaseID:	FBgn0035026	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_004706.3	Gene:	CTDP1 / 9150	HGNCID:	2498	Length:	961	Species:	Homo sapiens

Alignment Length:	993	Identity:	316/993 - (31%)
Similarity:	442/993 - (44%)	Gaps:	262/993 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 KWRVREGQFVSAAQILFLYQ-PVGVDAKDAKDAGKPGGDCA-----IQRYKSQRAGVVKKRLRKE 129
            :|||..|..|....:|.::: .....:..|..:....|.|.     .:|.:|:|||||::...:.
Human    34 EWRVAAGAAVRIGSVLAVFEAAASAQSSGASQSRVASGGCVRPARPERRLRSERAGVVRELCAQP 98

  Fly   130 GELLTKGDAILELSECIHTTVIKDMCADCGADLR--QNENGQ----TSEASVPMVHTMPDLKVTQ 188
            |:::..|..::.|..|.|..|:|.:||:||.||.  |::||:    .|.|:|.|||::|:|.|:.
Human    99 GQVVAPGAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSS 163

  Fly   189 KLAQKLGHDDTRRLLADRKLVLLVDLDQTVIHTTNDTVPD-NIKGIYHFQLYGPHSPWYHTRLRP 252
            :.|::||.:|.:||..:|||||:||||||:||||...... :.|||:|||| |...|..||||||
Human   164 EQAEQLGREDQQRLHRNRKLVLMVDLDQTLIHTTEQHCQQMSNKGIFHFQL-GRGEPMLHTRLRP 227

  Fly   253 GTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFSHRILSRDECFNATSKTDNLKALFP 317
            ...:|||::::|||||:.|||:|.|||.||..||||.|.|||||||||||.:..|||.||:.|||
Human   228 HCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILSRDECIDPFSKTGNLRNLFP 292

  Fly   318 NGDSMVCIIDDREDVWNMASNLIQVKPYHFFQHTGDINAPPGLSKHEL----------------- 365
            .|||||||||||||||..|.|||.||.|.:||.|||:|||||..:.:.
Human   293 CGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPGSRESQTRKKVNHSRGTEVSEPSP 357

  Fly   366 ---DGEGVD-----------FKEITEKHGDKDKT--ESSSEVKPEDTDKGDNTVTSTSKDDDVNE 414
               |.|||.           .|...|.:|.:..|  :|....||::.|........||..
Human   358 PVRDPEGVTQAPGVEPSNGLEKPARELNGSEAATPRDSPRPGKPDERDIWPPAQAPTSSQ----- 417

  Fly   415 ESVDVFEIEGDAKDPEVSNASSATEAP-KEPRDKLNGKTNAE-DIVVIDDSSSGSPD----AEKA 473
                  |:.| |.:|:.|.|.....|| :.|   ..|.|..: |..:..||.|.|..    :..:
Human   418 ------ELAG-APEPQGSCAQGGRVAPGQRP---AQGATGTDLDFDLSSDSESSSESEGTKSSSS 472

  Fly   474 ASDGEDVVVIDDNSKESTKAEVPPTPA---------EKNEVVASSTTSPDEKRPSADADVATTSK 529
            |||||     .:..:...|.:..|..|         |.....|.|.  |.|..|.|.|    ..|
Human   473 ASDGE-----SEGKRGRQKPKAAPEGAGALAQGSSLEPGRPAAPSL--PGEAEPGAHA----PDK 526

  Fly   530 TPSLRAPLEGQ--------------KQIEIE---------------------------DPDDYLL 553
            .|.|....||:              |:.|.|                           |.||:|:
Human   527 EPELGGQEEGERDGLCGLGNGCADRKEAETESQNSELSGVTAGESLDQSMEEEEEEDTDEDDHLI 591

  Fly   554 YLEVILRNIHKRFYSIYD-----ETTEIPDLKVIVPKIRSEVLRGKNLVFSGLVPTQMKLEQSRA 613
            |||.||..:|..:|:.||     |..|.||::.|||:::|:||....::||||.||...:|::|.
Human   592 YLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRKIVPELKSKVLADVAIIFSGLHPTNFPIEKTRE 656

  Fly   614 YFIAKSLGAEV------KPNIDKEITHLVAVNAGTYKVNAAKKEPAIKVVNANWLWTCAERWEHV 672
            ::.|.:|||::      .|:.....|||:|..|||.||..|::...:.|||.:|||:|.|||:.|
Human   657 HYHATALGAKILTRLVLSPDAPDRATHLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLERWDKV 721

  Fly   673 EEKLFPL-----------------DRK---------------------------------VRNKG 687
            ||:||||                 ||:                                 :|...
Human   722 EEQLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGA 786

  Fly   688 RQPPAHCHS---------------------PEHVVNYSERSEISPSSSKQQEEQSGNFRETLNPL 731
            |.|||...|                     .|.:.:..:..:..||..|:|...|    ||: ||
Human   787 RGPPAPSSSLPIRQEPSSFRAVPPPQPQMFGEELPDAQDGEQPGPSRRKRQPSMS----ETM-PL 846

  Fly   732 LVFTNADIESMNKDYETFF-----ESDSSSDEGPVNFENPPMDKKLLKRKREDDNSNRAHDFFTR 791
            ......|:|||:|:.:...     :|||.........|.|...|...:|:|
Human   847 YTLCKEDLESMDKEVDDILGEGSDDSDSEKRRPEEQEEEPQPRKPGTRRER-------------- 897

  Fly   792 SDDIMIGAPNLVEVDISSNEEADDNNEKEDDDDEMPSAKFRRGEDLPSDLELGSESNSEKEPEDE 856
                .:|||...|...:.......:..|.:::|                    :.|.|.:|..:|
Human   898 ----TLGAPASSERSAAGGRGPRGHKRKLNEED--------------------AASESSRESSNE 938

  Fly   857 DDG---EWNMMGAALERE 871
            |:|   |.:.|..|||.|
Human   939 DEGSSSEADEMAKALEAE 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fcp1	NP_001286846.1	Biotinyl_lipoyl_domains	59..142	CDD:299706	18/76 (24%)
		FCP1_euk	202..348	CDD:131304	94/146 (64%)
		COG5275	481..>658	CDD:227600	66/237 (28%)
		BRCT	587..665	CDD:278934	32/83 (39%)
CTDP1	NP_004706.3	Biotinyl_lipoyl_domains	21..111	CDD:299706	18/76 (24%)
		FCP1_euk	177..323	CDD:131304	94/146 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..589		62/286 (22%)
		BRCT	636..716	CDD:237994	30/79 (38%)
		FCP1_C	716..961	CDD:286402	59/284 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..752		2/21 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	780..949		42/211 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158686
Domainoid	1	1.000	175	1.000	Domainoid score	I3671
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2033
Isobase	1	0.950	-	0	Normalized mean entropy	S4270
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D405160at33208
OrthoFinder	1	1.000	-	-		FOG0005532
OrthoInspector	1	1.000	-	-		oto91306
orthoMCL	1	0.900	-	-		OOG6_102037
Panther	1	1.100	-	-	LDO	PTHR23081
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R439
SonicParanoid	1	1.000	-	-		X3392
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.870