DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fcp1 and FCP1

DIOPT Version :9

Sequence 1:	NP_001286846.1	Gene:	Fcp1 / 37925	FlyBaseID:	FBgn0035026	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_014004.1	Gene:	FCP1 / 855320	SGDID:	S000004890	Length:	732	Species:	Saccharomyces cerevisiae

Alignment Length:	809	Identity:	219/809 - (27%)
Similarity:	326/809 - (40%)	Gaps:	213/809 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 AKDAG--------KPGGDCAIQRYKSQRAGVVKKRLRK---------EGELL-----------TK 135
            |.|.|        .|||...     |.......|:||:         ||:|:           |.
Yeast    46 ASDTGDDDNEHDVSPGGSAG-----SNGVSPPTKQLRESIEFFESPYEGDLISWNVDVGDEVATA 105

  Fly   136 GDAILELSE-CIHTTVIKDMCADCGADLRQNENGQTSEA--SVPM-VHTMPDLKVTQKLAQKLGH 196
            ...|.|:.. |.|..|...:|..||.::       :::|  .||: |....||::::..|.:.|.
Yeast   106 NQVICEIKRPCNHDIVYGGLCTQCGKEV-------SADAFDGVPLDVVGDVDLQISETEAIRTGK 163

  Fly   197 DDTRRLLADRKLVLLVDLDQTVIHTTNDTV-------PDN-----IKGIYHF----QLYGP---- 241
            .....|..|:||:|:||||||:||...|..       |:|     ::.:..|    :|..|
Yeast   164 ALKEHLRRDKKLILVVDLDQTIIHCGVDPTIAEWKNDPNNPNFETLRDVKSFTLDEELVLPLMYM 228

  Fly   242 ------------HSPWYHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFSH 294
                        ...||:.::|||..||..:::.|:|:||.|...|.||..||:::||.|:.|..
Yeast   229 NDDGSMLRPPPVRKCWYYVKVRPGLKEFFAKVAPLFEMHIYTMATRAYALQIAKIVDPTGELFGD 293

  Fly   295 RILSRDECFNATSKTDNLKALFPNGDSMVCIIDDREDVWNMASNLIQVKPYHFFQHTGDINAPPG 359
            |||||||  |.:..|.:|..|||...|||.:||||.||||...|||:|.||:||...||||:
Yeast   294 RILSRDE--NGSLTTKSLAKLFPTDQSMVVVIDDRGDVWNWCPNLIKVVPYNFFVGVGDINS--- 353

  Fly   360 LSKHELDGEGVDFKEITEKHGDKDKTESSSEVKPEDTDKGDNTVTSTSKDDDVNEESVDVFEIEG 424
               :.|..:.....::..|  .:.|::.|.|:..:..|               ||:.:.
Yeast   354 ---NFLPKQSTGMLQLGRK--TRQKSQESQELLTDIMD---------------NEKKLQ------ 392

  Fly   425 DAKDPEVSNASSATEAPKEPRDKLNGKTNAEDIVVIDDSSSGSPDAEKAASDGEDVVVIDDNSKE 489
            :..|.||          |...:|||                                      .:
Yeast   393 EKIDKEV----------KRQEEKLN--------------------------------------HQ 409

  Fly   490 STKAEVPPTPAEKNEVV-----ASSTTSPDEKRPSADADVATTSKTPSLRAPLEGQKQIEIEDPD 549
            ...||.||....|.|:.     ::|.....:.||.|           .|:..|..||.  :.|.|
Yeast   410 LATAEEPPANESKEELTKKLEYSASLEVQQQNRPLA-----------KLQKHLHDQKL--LVDDD 461

  Fly   550 DYLLYLEVILRNIHKRFYSIYDETTE-IPDLKVIVPKIRSEVLRGKNLVFSGLVPTQMKLEQSRA 613
            |.|.||...|.||||.:|.:..:..| .|:|..|:|.::.:|.:....|||||:|....:::|..
Yeast   462 DELYYLMGTLSNIHKTYYDMLSQQNEPEPNLMEIIPSLKQKVFQNCYFVFSGLIPLGTDIQRSDI 526

  Fly   614 YFIAKSLGAEVKPNIDKEITHLVAVNAGTYKVNAAKK-EPAIKVVNANWLWTCAERWEHVEEKLF 677
            .....:.||...|:||...|||:..|..|||...||| .|.||:|:.:|::.|...|:.|:||.:
Yeast   527 VIWTSTFGATSTPDIDYLTTHLITKNPSTYKARLAKKFNPQIKIVHPDWIFECLVNWKKVDEKPY 591

  Fly   678 PL--DRKVRNKGRQPPAHCHSPEHVVNY----SERSEISPSSSKQQEEQSGNFRETLNPLLVFT- 735
            .|  |..:            |.|.:.|:    .:|.|....:.:||...:.  :|.||.....|
Yeast   592 TLIVDSPI------------SDEELQNFQTQLQKRQEYLEETQEQQHMLTS--QENLNLFAAGTS 642

  Fly   736 ---NADIESMNKDYETFFESDSSSDEGPVNFENPPMDKKLLKRKREDDNSNRAHDFFTRSDDIMI 797
               |.|.|.:........|.|...||......:..:|:|.......||.|.:.    |:::....
Yeast   643 WLNNDDDEDIPDTASDDDEDDDHDDESDDENNSEGIDRKRSIEDNHDDTSQKK----TKAEPSQD 703

  Fly   798 GAPNLVEVDISSNEEADDNNEKEDDDDEM 826
            |       .:....|.|||   ||.|.::
Yeast   704 G-------PVQHKGEGDDN---EDSDSQL 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fcp1	NP_001286846.1	Biotinyl_lipoyl_domains	59..142	CDD:299706	15/70 (21%)
		FCP1_euk	202..348	CDD:131304	70/177 (40%)
		COG5275	481..>658	CDD:227600	57/183 (31%)
		BRCT	587..665	CDD:278934	28/78 (36%)
FCP1	NP_014004.1	Biotinyl_lipoyl_domains	88..>112	CDD:416260	5/23 (22%)
FCP1	NP_014004.1	FCP1	150..623	CDD:227517	166/576 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346025
Domainoid	1	1.000	113	1.000	Domainoid score	I1354
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I1003
Isobase	1	0.950	-	0	Normalized mean entropy	S4270
OMA	1	1.010	-	-		QHG56016
OrthoFinder	1	1.000	-	-		FOG0005532
OrthoInspector	1	1.000	-	-		oto100172
orthoMCL	1	0.900	-	-		OOG6_102037
Panther	1	1.100	-	-	LDO	PTHR23081
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R439
SonicParanoid	1	1.000	-	-		X3392
TreeFam	1	0.960	-	-
	15	14.740