DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fcp1 and fcp1

DIOPT Version :9

Sequence 1:	NP_001286846.1	Gene:	Fcp1 / 37925	FlyBaseID:	FBgn0035026	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_594768.1	Gene:	fcp1 / 2542225	PomBaseID:	SPAC19B12.05c	Length:	723	Species:	Schizosaccharomyces pombe

Alignment Length:	848	Identity:	228/848 - (26%)
Similarity:	364/848 - (42%)	Gaps:	201/848 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 VREGQFVSAAQILFLYQPVGVDAKDAKDAGKPGGDCA-IQRYKSQRAG-VVKKRLRKEGELLTKG 136
            |.:|.:|.....|.||:......:|.:|..:...|.. :::::....| :|:..::||..:....
pombe    25 VPQGSYVKKGTPLLLYRFFTKVKEDQEDGSEVYVDREFVEQFECPVEGELVEWAVKKEESIENFS 89

  Fly   137 DAILELSE-CIHTTVIKDMCADCGADLRQNE---NGQTSEASVPMVHTMPDLKVTQKLAQKLGHD 197
            ..:.:|.| |.|......:||.||.::...:   ....:.|::.|.|...||.|:.:.|.:|..:
pombe    90 KIVAKLHEPCTHEVNYGGLCAICGKNITSQDYMGYSDMARANISMTHNTGDLTVSLEEASRLESE 154

  Fly   198 DTRRLLADRKLVLLVDLDQTVIHTTND-TV------PDNI-----KGIYHFQLY-GP--HSPWYH 247
            :.:||..:::|.|:||||||:||.|.| ||      |.|:     :.:..|.|. ||  ::..|:
pombe   155 NVKRLRQEKRLSLIVDLDQTIIHATVDPTVGEWMSDPGNVNYDVLRDVRSFNLQEGPSGYTSCYY 219

  Fly   248 TRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFSHRILSRDECFNATSKTDNL 312
            .:.|||.|:||:::|:||||||.|.|.:.||..:|:::||.||.|..|:||||:..:...|  :|
pombe   220 IKFRPGLAQFLQKISELYELHIYTMGTKAYAKEVAKIIDPTGKLFQDRVLSRDDSGSLAQK--SL 282

  Fly   313 KALFPNGDSMVCIIDDREDVWNMASNLIQVKPYHFFQHTGDINA-----PPGLSKHELDGEGVDF 372
            :.|||...|||.:||||.|||:...|||:|.||.||...||||:     ...|.:.|
pombe   283 RRLFPCDTSMVVVIDDRGDVWDWNPNLIKVVPYEFFVGIGDINSNFLAKSTPLPEQE-------- 339

  Fly   373 KEITEKHGDKDKTESSSEVKPEDTDKGDNTVTSTSKDDDVNEESVDVFEIEGDAKDPEVSNASSA 437
             ::......||:.:|.                     |::|||:.:..|.:.       ||:|.|
pombe   340 -QLIPLEIPKDEPDSV---------------------DEINEENEETPEYDS-------SNSSYA 375

  Fly   438 TEAPKEPRDKLNGKTNAEDIVVIDDSSSGSPDAEKAASDGEDVVVIDDNSKESTKAEVPPTPAEK 502
            .::...|...|...|..::...:::.:.            |.|..::....|.      |...::
pombe   376 QDSSTIPEKTLLKDTFLQNREALEEQNK------------ERVTALELQKSER------PLAKQQ 422

  Fly   503 NEVVASSTTSPDEKRPSADADVATTSKTPSLRAPLEGQKQIEIEDPDDYLLYLEVILRNIHKRFY 567
            |.::      .||.:|           |||         ...:.:.|..|..||.:|::||..:
pombe   423 NALL------EDEGKP-----------TPS---------HTLLHNRDHELERLEKVLKDIHAVY- 460

  Fly   568 SIYDETTEI---------PDLKVIVPKIRSEVLRGKNLVFSGLVPTQMKLEQSRAYFIAKSLGAE 623
              |:|..:|         .::.:|:||::.:||:|..|:|||::|..:.:..|.....|.|.|||
pombe   461 --YEEENDISSRSGNHKHANVGLIIPKMKQKVLKGCRLLFSGVIPLGVDVLSSDIAKWAMSFGAE 523

  Fly   624 VKPNIDKEITHLVAVNAGTYKVNAAKKEPAIKVVNANWLWTCAERWEHVEEK---LFP-LDRKVR 684
            |..:.....|||:|....|.||..|.....||||..|||.....:|:.:.|.   |:| .|...|
pombe   524 VVLDFSVPPTHLIAAKIRTEKVKKAVSMGNIKVVKLNWLTESLSQWKRLPESDYLLYPSYDLPDR 588

  Fly   685 NKGRQPPAHCHSPEHVVNYSERSEISPSSSKQQEEQSGNFRETLNPLLVFTNADIESMNKDYETF 749
            |                    .||.|.|||...|::                  |..:|
pombe   589 N--------------------LSEHSYSSSSDDEQR------------------ISELN------ 609

  Fly   750 FESDSSSDEGPVNFENPPMDKKLLKRKREDDNSNRAHDFFTRSDDIMIGAPNLVEVDISSNEEAD 814
               |...||  ::::....|.:...:...|||     ||.|.|.......|..:||:.....:||
pombe   610 ---DRELDE--IDWQAADQDVENALKDLSDDN-----DFDTGSISASQSQPEALEVNTPIKRKAD 664

  Fly   815 ----------DNNEKEDDDDEMPSAKFRRGED-LPSDLELGSESNSEKEPEDEDDGEWNMMGAAL 868
                      :...||:|:.|        |.| ||:....|.||   .|.|:|.|...::|.|.|
pombe   665 LIQPSYNYDGEKRRKENDNHE--------GYDLLPNSSTKGEES---AENENELDDLADIMEAEL 718

  Fly   869 ERE 871
            .::
pombe   719 SKD 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fcp1	NP_001286846.1	Biotinyl_lipoyl_domains	59..142	CDD:299706	13/69 (19%)
		FCP1_euk	202..348	CDD:131304	71/160 (44%)
		COG5275	481..>658	CDD:227600	48/185 (26%)
		BRCT	587..665	CDD:278934	30/77 (39%)
fcp1	NP_594768.1	FCP1	139..609	CDD:227517	169/593 (28%)
		FCP1_euk	159..318	CDD:131304	71/160 (44%)
		BRCT	510..561	CDD:294035	19/50 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	124	1.000	Domainoid score	I1419
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I932
OMA	1	1.010	-	-		QHG56016
OrthoFinder	1	1.000	-	-		FOG0005532
OrthoInspector	1	1.000	-	-		oto101927
orthoMCL	1	0.900	-	-		OOG6_102037
Panther	1	1.100	-	-	LDO	PTHR23081
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R439
SonicParanoid	1	1.000	-	-		X3392
TreeFam	1	0.960	-	-
	13	12.860