DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fcp1 and fcp-1

DIOPT Version :9

Sequence 1:	NP_001286846.1	Gene:	Fcp1 / 37925	FlyBaseID:	FBgn0035026	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_492423.2	Gene:	fcp-1 / 172719	WormBaseID:	WBGene00009479	Length:	659	Species:	Caenorhabditis elegans

Alignment Length:	870	Identity:	250/870 - (28%)
Similarity:	350/870 - (40%)	Gaps:	289/870 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 NEARAVINKWRVREGQFVSAAQILFLYQPVGVDAKDAKDAGKPGGDCAIQRYKSQRAGVVK--KR 125
            |:|.......:..||.||....:|..::..|      |.|||         .|:...|||.  |.
Worm     8 NDAECTAGLKKASEGSFVLKDHVLIEFKING------KVAGK---------IKTPCEGVVTFGKG 57

  Fly   126 LRKEGELLTKGDAILELSECIHTTVIKDMCADCGADLRQ-----NENGQTSEASVPMVHTMPDLK 185
            | |.|.:|.||..|..:|||.|..|||||||.||.|||:     .:..:.|.|:|.|:|.:|:|.
Worm    58 L-KPGIVLNKGQVIATVSECTHAIVIKDMCATCGKDLREKGGRAGQRKEQSTANVSMIHHVPELI 121

  Fly   186 VTQKLAQKLGHDDTRRLLADRKLVLLVDLDQTVIHT-----TNDTVPDNIKGIYHFQLYGPHSPW 245
            |:..||:::|..|...|:.:||||||||||||:|||     |.||  :|.|.|..:.|   ||..
Worm   122 VSDTLAKEIGSADENNLITNRKLVLLVDLDQTIIHTSDKPMTVDT--ENHKDITKYNL---HSRV 181

  Fly   246 YHTRLRPGTAEFLERMSQLYELHICTFGARNYAHMIAQLLDPEGKFFSHRILSRDECFNATSKTD 310
            |.|:|||.|.|||.:||.:||:||.|:|.|.|||.|||:|||:.:.|..|||||||.|:|..||:
Worm   182 YTTKLRPHTTEFLNKMSNMYEMHIVTYGQRQYAHRIAQILDPDARLFEQRILSRDELFSAQHKTN 246

  Fly   311 NLKALFPNGDSMVCIIDDREDVWNMASNLIQVKPYHFFQHTGDINAPPGLSKHELDGEGVDFKEI 375
            |||||||.||::|.|||||.|||..:..|||:|||.||:..||||||
Worm   247 NLKALFPCGDNLVVIIDDRSDVWMYSEALIQIKPYRFFKEVGDINAP------------------ 293

  Fly   376 TEKHGDKDKTESSSEVKPEDTDKGDNTVTSTSKDDDVNEESVDVFEIEGDAKDPEVSNASSATEA 440

Worm   294 ----------------------------------------------------------------- 293

  Fly   441 PKEPRDKLNGKTNAEDIVVIDDSSSGSPDAEKAASDGEDVVVIDDNSKESTKAEVPPTPAEKNEV 505
                                                        .||||
Worm   294 --------------------------------------------KNSKE---------------- 298

  Fly   506 VASSTTSPDEKRPSADADVATTSKTPSLRAPLEGQKQIEIED---PDDYLLYLEVILRNIHKRFY 567
                                              |..::|||   .|..|..:|.:|.|||.::|
Worm   299 ----------------------------------QMPVQIEDDAHEDKVLEEIERVLTNIHDKYY 329

  Fly   568 SIYD---ETTEIPDLKVIVPKIRSEVLRGKNLVFSGLVPTQMKLEQSRAYFIAKSLGAEVKPNID 629
            ..:|   ....:.|:|.::.:.|.:||.|..:||||:||...|||::..|.:....||.:.|::.
Worm   330 EKHDLRGSEEVLLDVKEVIKEERHKVLDGCVIVFSGIVPMGEKLERTDIYRLCTQFGAVIVPDVT 394

  Fly   630 KEITHLVAVNAGTYKVNAAKKEPAIKVVNANWLWTCAERWEHVEEKLFPLDRKVRNKGRQPPAHC 694
            .::||:|....||.||..|.:.... ||...|::.|.|:|...:|.||.|     .|...||..
Worm   395 DDVTHVVGARYGTQKVYQANRLNKF-VVTVQWVYACVEKWLKADENLFQL-----TKESTPPVG- 452

  Fly   695 HSPEHVVNYSERSEISPSSSKQQEEQSGNFRETLNPLLVFTNADIESMNKDYETFFESDSSSDEG 759
                           .|..||...:.: |........|...|.:::....|.|...:::...|:|
Worm   453 ---------------RPLGSKYVNDLA-NMDTIGKAALADMNNEVDEALSDDEDDGDNEDEDDDG 501

  Fly   760 -----PVNFENPPMDKKLLKRKREDDNSNRAHDFFTRSDDIMIGAPNLVEVDISS---------- 809
                 ....||  :::|..|.:.|.|:..:......:|.|.:..     |.|.:|
Worm   502 NDVGEDKGDEN--LEEKQEKNEEEMDDVEQNGSVENQSGDALEN-----ETDSTSRGQKRKHCPE 559

  Fly   810 --NEEADDNNEKEDDDDEMP-----SAKFRRGEDLPS--------------------DLELGSES 847
              :||.:.:::.||||..|.     |...::|..:|.                    |.|...|.
Worm   560 MEDEEEESDSDNEDDDTPMSYKALLSDSRKKGRIVPENEDDAVFDVDDEKGHAPANIDEEEDDED 624

  Fly   848 NSEKE-PEDEDDGEWNMMGAALERE 871
            |.::| ||.:||.|:..|.|.:||:
Worm   625 NEDEEVPESDDDDEFEDMAALIERQ 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fcp1	NP_001286846.1	Biotinyl_lipoyl_domains	59..142	CDD:299706	24/80 (30%)
		FCP1_euk	202..348	CDD:131304	88/150 (59%)
		COG5275	481..>658	CDD:227600	45/182 (25%)
		BRCT	587..665	CDD:278934	28/77 (36%)
fcp-1	NP_492423.2	HAD_like	138..284	CDD:328728	88/150 (59%)
fcp-1	NP_492423.2	BRCT	358..431	CDD:237994	26/73 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166243
Domainoid	1	1.000	165	1.000	Domainoid score	I2368
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	354	1.000	Inparanoid score	I1314
Isobase	1	0.950	-	0	Normalized mean entropy	S4270
OMA	1	1.010	-	-		QHG56016
OrthoDB	1	1.010	-	-		D683531at2759
OrthoFinder	1	1.000	-	-		FOG0005532
OrthoInspector	1	1.000	-	-		oto17299
orthoMCL	1	0.900	-	-		OOG6_102037
Panther	1	1.100	-	-	LDO	PTHR23081
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R439
SonicParanoid	1	1.000	-	-		X3392
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750