Protein Alignment CG11414 and ZNF598

DIOPT Version :9

• Sequence 1: NP_611932.2
• Gene: CG11414 / 37923
• FlyBaseID: FBgn0035024
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_835461.2
• Gene: ZNF598 / 90850
• HGNCID: 28079
• Length: 904
• Species: Homo sapiens
• Alignment Length: 993
• Identity: 292/993 - (29%)
• Similarity: 416/993 - (41%)
• Gaps: 271/993 - (27%)

  Fly    30 AAVKPEALESYTGNDDNACVVCFKNVEIFSIGDCDHPVCYECSTRMRVLCQQNECPICRHVLSKV 94
            ||..||       ....:||:|..::|..::|.|||||||.|||:|||||:|..|.:||..|.:|
Human    18 AAAAPE-------RGGGSCVLCCGDLEATALGRCDHPVCYRCSTKMRVLCEQRYCAVCREELRQV 75

  Fly    95 LF-----TLDKLPYRELEANNRSDLYSKKYRIGFCTAEIRQQFFKLLDHPCPKC-DAPPYRTFEG 153
            :|     ....:|..:|:       :.|||.|.|...::...:.:||.|.||:| :.||:..|..
Human    76 VFGKKLPAFATIPIHQLQ-------HEKKYDIYFADGKVYALYRQLLQHECPRCPELPPFSLFGD 133

  Fly   154 LRNHVRSEHKLLYCDLCVETLNIFTFERRCYTQAELQLHNTKGDPDNRSHRGHPLCEYCNKRYVD 218
            |..|:|.:|:|..|.||::.|.|||:||:.|::.:|..|..:||||:.||||||||::|::||:|
Human   134 LEQHMRRQHELFCCRLCLQHLQIFTYERKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDERYLD 198

  Fly   219 RDELFRHLRREHYFCHFCDADGCNEFYNDYADLAEHFRAEHFLCEEGKCATEQFVGAFRNEIEYK 283
            .|||.:||||:||||||||:||..::|:|||.|.||||.:|||||||:|:||||..|||.||:.|
Human   199 NDELLKHLRRDHYFCHFCDSDGAQDYYSDYAYLREHFREKHFLCEEGRCSTEQFTHAFRTEIDLK 263

  Fly   284 AHVANVHGKSLNKQQAKQTRTLQVEITLGPR--------------------------GRSG---- 318
            ||....|.:|  :.:|:|.|.:.::.:..||                          .|:|
Human   264 AHRTACHSRS--RAEARQNRHIDLQFSYAPRHSRRNEGVVGGEDYEEVDRYSRQGRVARAGTRGA 326

  Fly   319 -QTEQG-------------ITSVRT-----------RNDEHND---------------------- 336
             |:.:|             ..:||.           |:::..:
Human   327 QQSRRGSWRYKREEEDREVAAAVRASVAAQQQEEARRSEDQEEGGRPKKEEAAARGPEDPRGPRR 391

  Fly   337 ---YQNDLPS---------ITQRHVSIDAG-------------------NEEQFPTLRGASTAPS 370
               .|.:.|.         ::|...|:...                   .:|.||:| .|||:.|
Human   392 SPRTQGEGPGPKETSTNGPVSQEAFSVTGPAAPGCVGVPGALPPPSPKLKDEDFPSL-SASTSSS 455

  Fly   371 VSLVRPPPPSMRNL------SGTSGLARTKENFPALGGGNGGGVTGPT-------SSSIAARAAQ 422
            .|....|.|....|      .|.|  |..:|:||||........|.||       |||.:.:.||
Human   456 CSTAATPGPVGLALPYAIPARGRS--AFQEEDFPALVSSVPKPGTAPTSLVSAWNSSSSSKKVAQ 518

  Fly   423 SQHPVAAVFK---KPTSAAGSGSRSGPPGNGMLLHVSNRSAAVPKKAATPQVDFPALPGKGNKKN 484
            .  |::|...   :||..||.|||.|                                .||....
Human   519 P--PLSAQATGSGQPTRKAGKGSRGG--------------------------------RKGGPPF 549

  Fly   485 LRNLEEDMLPSGSPVPMANISAKHRSLADDYVSVAS--PSTFQKLQMVQKEEDEAKARQEALKKS 547
            .:..|||    |.|.....:|.:........:.:||  ||...|.:.|..|:......|......
Human   550 TQEEEED----GGPALQELLSTRPTGSVSSTLGLASIQPSKVGKKKKVGSEKPGTTLPQPPPATC 610

  Fly   548 AP-KLTAAEFPSL---GPSASASSSRTTAPKPSSGSPSLNWSKPANEKKQRELENRKAKVAPAPV 608
            .| .|.|.|.|:.   ||.|...:.....|.|:..:|    .:|                   |.
Human   611 PPGALQAPEAPASRAEGPVAVVVNGHMEGPAPARSAP----KEP-------------------PG 652

  Fly   609 LPSPT-SKPAPKASNNNVQEQQANKKDKKQKDKKSNQENQPKTA------KPKERNNNNEQKTNG 666
            ||.|. |.|.|                       :.||:.|...      .|.....:......|
Human   653 LPRPLGSFPCP-----------------------TPQEDFPALGGPCPPRMPPPPGFSAVVLLKG 694

  Fly   667 APSTPIRAPPGLKPGGPL-KPPPGFVSNVTVNSVAKLPNNLTFTNSLGESYDIVPSPYTYTDPPD 730
            .|..|   ||||.|  |: ||||||...:.....|.:|:..|.|.:  ::..::|:|..|..|.:
Human   695 TPPPP---PPGLVP--PISKPPPGFSGLLPSPHPACVPSPATTTTT--KAPRLLPAPRAYLVPEN 752

  Fly   731 TEVRNQKLVDEVMSLLKTPEA-LNEFRLLSSKFRDGSCSGQAYYEHCQCAMLSSFYNLFPELLAM 794
            ...||.:|:..:...|::.|| .:||:..|.:||.|..|...||:.|:..:..:|..:|.|||.:
Human   753 FRERNLQLIQSIRDFLQSDEARFSEFKSHSGEFRQGLISAAQYYKSCRDLLGENFQKVFNELLVL 817

  Fly   795 LPDISKQQELYLVHKQHLNSLPPAERKSVP---------------ALEVCKVCKQILITADLKSH 844
            |||.:|||||...|....|...|...||..               ...||..|:|:|...|..||
Human   818 LPDTAKQQELLSAHTDFCNREKPLSTKSKKNKKSAWQATTQQAGLDCRVCPTCQQVLAHGDASSH 882

  Fly   845 QQAHEL-TKNFPVLGSSA 861
            |..|.. ..:||.|.:.|
Human   883 QALHAARDDDFPSLQAIA 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11414	NP_611932.2	COG5236	2..>294	CDD:227561	127/269 (47%)
		zf-C3HC4_3	44..94	CDD:290631	25/49 (51%)
		DUF4187	<220..259	CDD:290533	26/38 (68%)
ZNF598	NP_835461.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..469		22/157 (14%)
		DUF4666	<364..440	CDD:292325	4/75 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	490..656		49/226 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158521
Domainoid	1	1.000	314	1.000	Domainoid score	I1295
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	372	1.000	Inparanoid score	I2125
Isobase	1	0.950	-	0	Normalized mean entropy	S4001
OMA	1	1.010	-	-		QHG59837
OrthoDB	1	1.010	-	-		D1003372at2759
OrthoFinder	1	1.000	-	-		FOG0004142
OrthoInspector	1	1.000	-	-		oto88660
orthoMCL	1	0.900	-	-		OOG6_101580
Panther	1	1.100	-	-	LDO	PTHR22938
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1900
SonicParanoid	1	1.000	-	-		X2895
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.980