DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11414 and SPCC1223.01

DIOPT Version :9

Sequence 1:	NP_611932.2	Gene:	CG11414 / 37923	FlyBaseID:	FBgn0035024	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_588346.2	Gene:	SPCC1223.01 / 2539079	PomBaseID:	SPCC1223.01	Length:	732	Species:	Schizosaccharomyces pombe

Alignment Length:	764	Identity:	185/764 - (24%)
Similarity:	301/764 - (39%)	Gaps:	209/764 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DGVANTTTDNAAVKPEALESYTGNDDNACVVCFKNVEIFSIGDCDHPVCYECSTRMRVLCQQNEC 84
            |.|:|..|.:|: |.|..|     |:..|.:|.:.:....:..|:|.:|:.|:.|:|.|.:..||
pombe    59 DPVSNVATVDAS-KEEQDE-----DEQICFICAEGITYSCVLPCNHRMCHVCALRLRALYKTKEC 117

  Fly    85 PICRHVLSKVLFTLD-----------KLPYRELEANNRSDLYSKKYRIGFCTAEIRQQFFKLLDH 138
            ..|:.....||.|.|           |||:::           :|..|.:.....:::...||..
pombe   118 TFCKTEWDTVLITKDHEIDIHDVDLAKLPFQD-----------EKLGIVYSDEHAQEESNLLLQF 171

  Fly   139 PCPK--CDAPPYRTFEGLRNHVRSEHKLLYCDLCVETLNIFTFERRCYTQAELQLHNTKGDPDN- 200
            .||:  ||......|: |:.|.:.:|...:|||||:...:||.|...:::..|..||..||..:
pombe   172 NCPEDACDITCKGWFD-LKLHAKVKHHKFFCDLCVKNKKVFTHEHTLFSKKGLTKHNEVGDQGSD 235

  Fly   201 ---RSHRGHPLCEYCNKRYVDRDELFRHLRREHYFCHFCD---ADGCNEFYNDYADLAEHFRAEH 259
               ...:|||.||:||..:.|.||||:|.|.:|..|:.||   ....::::.:|..|..||..:|
pombe   236 LEITGFKGHPKCEFCNTHFYDDDELFKHCREKHERCYICDQVAGRPTHQYFKNYDSLERHFEKDH 300

  Fly   260 FLCEEGKCATEQFVGAFRNEIEYKAHVANVHGKSLNKQQAKQTRTLQVEITLGPRGRSGQTEQGI 324
            ::|.|.:|...:|| .|..||:.|||..:.|..:..:::.::.|.:..:.:..|.|.||:..:..
pombe   301 YICRERECLERKFV-VFGTEIDLKAHQLDEHPHNFTQRELREARRIIPQFSYDPPGASGRNRRER 364

  Fly   325 TSVRTRNDEHNDYQNDLPSITQRHVS---IDAGNEEQFPTLRGASTAP-SVSLVRPPPPSMRNLS 385
            || .|.:::.........|::..|:|   |....:|::...:.|.... ..:|..|.|.|.|..:
pombe   365 TS-STPSEQSTSVNETANSLSNLHLSRGEIAHLRQEEYVREQQARHRDFGFTLSNPAPTSARPAT 428

  Fly   386 GTSGLARTK------ENFPALGGGNGGGVTGPTSSSIAARAAQSQHPVAAVFKKPTSAAGSGSRS 444
            .|..::|.|      |:||:|     ..|....|||..:      .||:|    |..:..|.||:
pombe   429 STRTISRGKTRTLRNEDFPSL-----AEVANQNSSSAPS------VPVSA----PRLSGKSASRN 478

  Fly   445 GPPGNGMLLHVSNRSAAVPKKAATPQVDFPALPGKGNKKNLRNLEE------------------- 490
            ..|.                            |.||.|..:.:.|:
pombe   479 HVPS----------------------------PPKGTKSPMASSEQAQHQQVIDRMQKLTNYDDH 515

  Fly   491 --------------DMLPSGSPVP-MANISAK-HRSLADDYVSVASPSTFQKLQMVQKEEDEAKA 539
                          :::|:...|. :..:.|| |..|:..:..:|:     .|:..:|..:..:|
pombe   516 KINDFKFAVSSFRGNVMPAREAVARITKLVAKPHEQLSGVFNQIAN-----LLENKEKSRELLEA 575

  Fly   540 RQE--------------------ALKKSAPKLTAAEFPSL-----------GPSASASSSR---- 569
            .||                    .||:|  ..|||:..|:           |||.||.||.
pombe   576 WQEWKILNAKDDTRIGTTNSNLLRLKRS--NRTAAQTASVWNRIERAAAHDGPSLSAPSSSINLA 638

  Fly   570 --TTAPKPSSGSPSLNWSKPANEKKQRELENRKAKVAPA--------PVLPSPTSKPAPKASNNN 624
              |:.|..||.:.:.:|..            |||:.:..        |.||..|||      ..:
pombe   639 NITSRPTNSSAANTPSWGV------------RKARASALNARSEEDFPALPPSTSK------RIS 685

  Fly   625 VQEQQANKKDKKQKDKKSNQENQPKTAKPKERNNNN---EQKTNGAPST 670
            ||      ..|||.....:..:.|.|:  ..||:|.   .:|.||...|
pombe   686 VQ------LGKKQARPVDSWGSTPNTS--SNRNSNTMGVSKKKNGKKQT 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11414	NP_611932.2	COG5236	2..>294	CDD:227561	88/293 (30%)
		zf-C3HC4_3	44..94	CDD:290631	13/49 (27%)
		DUF4187	<220..259	CDD:290533	14/41 (34%)
SPCC1223.01	NP_588346.2	COG5236	7..>383	CDD:227561	96/343 (28%)
SPCC1223.01	NP_588346.2	zf-C3HC4_3	77..127	CDD:290631	13/49 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5236
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004142
OrthoInspector	1	1.000	-	-		oto100598
orthoMCL	1	0.900	-	-		OOG6_101580
Panther	1	1.100	-	-	LDO	PTHR22938
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1900
SonicParanoid	1	1.000	-	-		X2895
TreeFam	1	0.960	-	-
	10	9.800