DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nurf-38 and PPA1

DIOPT Version :9

Sequence 1:	NP_523849.3	Gene:	Nurf-38 / 37922	FlyBaseID:	FBgn0016687	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_066952.1	Gene:	PPA1 / 5464	HGNCID:	9226	Length:	289	Species:	Homo sapiens

Alignment Length:	291	Identity:	160/291 - (54%)
Similarity:	201/291 - (69%)	Gaps:	4/291 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 MALYETVEKGAKNSPSYSLYFKNKCGNVISPMHDIPLYANEEKTIYNMVVEVPRWTNAKMEISLK 113
            |:.:.|.|:.|..|..|.::.||:.|..|||.||||:||  :|.:::||||||||:||||||:.|
Human     1 MSGFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYA--DKDVFHMVVEVPRWSNAKMEIATK 63

  Fly   114 TPMNPIKQDIKKGKLRFVANCFPHKGYIWNYGALPQTWENPDHIEPSTGCKGDNDPIDVIEIGYR 178
            .|:||||||:||||||:|||.||:|||||||||:|||||:|.|.:..|||.||||||||.|||.:
Human    64 DPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSK 128

  Fly   179 VAKRGDVLKVKVLGTIALIDEGETDWKIIAIDVNDPLASKVNDIADVDQYFPGLLRATVEWFKIY 243
            |..||:::.|||||.:|:|||||||||:|||:|:||.|:..|||.||.:..||.|.|||:||:.|
Human   129 VCARGEIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKPGYLEATVDWFRRY 193

  Fly   244 KIPDGKPENQFAFNGDAKNADFANTIIAETHKFWQNLVHQSPASGSISTTNITNRNSEHVIPKEE 308
            |:|||||||:||||.:.|:.|||..||..||..|:.||.:......||..|.|...|......:.
Human   194 KVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTLSESPFKCDPDA 258

  Fly   309 AEKIL-AEAPDGGQVEEVSDTVDTWHFIHLK 338
            |..|: |..|.......|...||.| |.|.|
Human   259 ARAIVDALPPPCESACTVPTDVDKW-FHHQK 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nurf-38	NP_523849.3	pyrophosphatase	26..292	CDD:294149	145/242 (60%)
PPA1	NP_066952.1	pyrophosphatase	4..241	CDD:412231	143/238 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159745
Domainoid	1	1.000	272	1.000	Domainoid score	I1812
eggNOG	1	0.900	-	-		E1_COG0221
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5356
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2466
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53511
OrthoDB	1	1.010	-	-		D1398991at2759
OrthoFinder	1	1.000	-	-		FOG0001608
OrthoInspector	1	1.000	-	-		otm41046
orthoMCL	1	0.900	-	-		OOG6_100346
Panther	1	1.100	-	-	O	PTHR10286
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2162
SonicParanoid	1	1.000	-	-		X1018
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800