Protein Alignment KEL and Nepl20

DIOPT Version :10

• Sequence 1: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Alignment Length: 715
• Identity: 166/715 - (23%)
• Similarity: 280/715 - (39%)
• Gaps: 143/715 - (20%)

Human   106 NTSVAPCTDFFSFACGRAKETNNSFQ---------ELATKNKNRLRRILEVQNSWHPGSGEEKAF 161
            |..|.||.||::|:||..|..|::..         |..||..|  |:||::.|:.|......:..
  Fly    53 NQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLN--RKILKMLNTPHDSHDTPEDI 115

Human   162 Q---FYNSCMDTLAIEAAGTGPLRQVIEELGGWRI--SGKWTSLNF---NRTLRLLMSQYGHFPF 218
            |   ||.||:....:.:..:..|:::|.|.|...:  ...|...:|   |.|.| :..:||....
  Fly   116 QVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTAR-MAHRYGIMSI 179

Human   219 FRAYLGPHPASPHTPVIQIDQPEFDVPLK-----QDQEQKIYAQ--------IFREYLTYLNQLG 270
            ....:....|:....:|.|:|.||  |||     .|.|..||.|        |..:||...::|.
  Fly   180 IGVGVATDFANNQKNIIYINQQEF--PLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGVKDELA 242

Human   271 TLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKE-MAPAIDWLSCLQA 334
            .      ...:|.....:.:...|....:.|..|    .|.:::|:.:|:| .||.:|   ..|.
  Fly   243 R------KAAKEMFEFEVDLAHGLVDNNKHLNLR----DLIELLTVAELRERYAPTLD---TDQL 294

Human   335 TFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRK 399
            .|..|....|..:..::..|.:|:.:::|.   ..:..:.:::.|.|:
  Fly   295 IFVSMGEKISDKVYEYNRRYQQNLVEVIER---TPKSTVANYLFLRLI----------------- 339

Human   400 LSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVR----EAFGPSTRSAAMKLFTAIRD 460
                 .|..::|...|......||:.|.|:|...|..:..|    |.......|...:|.:..::
  Fly   340 -----WEFIQKPSGVAEKPTEACVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKE 399

Human   461 ALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVR 525
            .|::. ..|.|:...|:::|..|:..:.:|:.    ....|...:|:.|:.|.::      .||.
  Fly   400 TLLSS-PALDWIEPSTRSLAIAKLEAMTLEVN----NYVKENFTEEFADLNLQNT------DCVE 453

Human   526 SLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVS------DHVVVFPAGLLQPPF-FHPGYPRAVN 583
            :||...:....|....:.....|.:.....|.:      ::.:..|..||||.: :...||.||.
  Fly   454 NLRQVQMLQAKQMRQLYHQPAKPLEAGELLSYTPSNILLENSIKVPVALLQPFYIWSDVYPNAVM 518

Human   584 FGAAGSIMAHELLHIFYQLLLPGGCLACDNHALQ--------------------EAHLCLKRHYA 628
            ||....::.|||:|.|            |:...:                    :...|..:.|.
  Fly   519 FGTLAYLIGHELIHGF------------DDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYG 571

Human   629 AFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSK----RLLRHHG-----ETVLPSLDLSPQQI 684
            .: :.......:|....||.||.||:.:|..||.|    :|...:|     :..||:|..:.:|:
  Fly   572 RY-VYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQL 635

Human   685 FFRSYAQVMCRKPSP-----QDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 744
            ||.|:||..|....|     |.|.|.|.|...||.|.||:...|::.|.|..|:.:||..:|.|:
  Fly   636 FFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKCILY 700

Human   745  744
              Fly   701  700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KEL	XP_005250050.1	M13	109..742	CDD:341056	163/708 (23%)
Nepl20	NP_651645.1	M13	56..697	CDD:341056	163/707 (23%)