Protein Alignment KEL and Nep7

DIOPT Version :10

• Sequence 1: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_651603.1
• Gene: Nep7 / 43356
• FlyBaseID: FBgn0039564
• Length: 717
• Species: Drosophila melanogaster
• Alignment Length: 791
• Identity: 181/791 - (22%)
• Similarity: 296/791 - (37%)
• Gaps: 204/791 - (25%)

Human    69 LLLCFSVLLFYN---FQNCGPRPCETSVCLDLRDHYLASG-------NTSVAPCTDFFSFACGRA 123
            |.:|..:.:..|   .::.|....|.::..:..|:..:.|       |.||.||.||:.||||..
  Fly    16 LAVCILICVILNDCEARSIGDESHENAITDETADYLRSHGAMMKSYMNFSVDPCDDFYEFACGNW 80

Human   124 KETNNSFQ--------------------ELATKNKNRLRRILEVQNSWHPGSGEEKAFQ-FYNSC 167
            |......|                    :|.|:.|  |...|.|       |.|....| |||||
  Fly    81 KNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRTK--LAEALNV-------SAELLVAQRFYNSC 136

Human   168 MDTLAIEAAGTGP-LRQVIEELGG--------WRISG-KWTSLNFNRTLRLLMSQYGHFPFFRAY 222
            :...........| ...||..|||        |..|. .|    ||.:..|  |.||    .|:.
  Fly   137 LAAELFPRPAADPAYLSVIRSLGGFPAVDRDAWNASSFSW----FNMSAHL--SNYG----VRSL 191

Human   223 LGPH--PASPHTPVIQIDQPEFD-------VPLKQDQEQKIYAQIFREYLTYLN----QLGTLLG 274
            :...  |..|..|..::.:..||       |.....:..::.....|.||...|    ::..::.
  Fly   192 IHEEILPQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEHRMRGYLKEYNLTKDEISAVIE 256

Human   275 GDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPM 339
            |    |....|.::||..:       .|..|.:..|     :.:::|:.....|.|..:..:..:
  Fly   257 G----VFAFWSEALSIEDK-------FESDRDKCDL-----LSEIEEVPRFGQWRSYYEIAWNGI 305

Human   340 SL-SPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQK 403
            .. :.|......|..|::     ::::..|..:.:.:::.:..:.               ::..|
  Fly   306 DFYNGSSGGEFCDFYYVE-----LDKVCAKHTEAVANYLAMRFLY---------------RMDDK 350

Human   404 LRELTEQPPMPARPRWMK--CVEETGTFFEPTLAALFVR----EAFGPSTRSAAMKLFTAIRDAL 462
            |:|       |.:|...|  |:    ...:.||..||.|    |.|.....|....:.|.:|.|.
  Fly   351 LKE-------PKQPEDQKVNCL----MIVQMTLPNLFNRLYMAEHFTDEKHSEISDMVTEMRKAQ 404

Human   463 ITRLRNLPWMNEETQNMAQDKVAQLQVEMGA-SEWALKPELARQEYNDIQLGSSFLQSVLSCVRS 526
            ...|.::.|::.||:..|..|.|.:...:|: ....|...|.|:..|...:..|:.||:::
  Fly   405 RQILESVEWLDAETRAEALSKEAGITPVIGSYKNEELSDTLIREINNLTIVEGSYAQSLIN---- 465

Human   527 LRARIVQSFLQPHPQHRW----------KVSP------WDVNAYYSVSDHVVVFPAGLLQPPFFH 575
              .|::.::|     ||:          ...|      ..|||:|...|:.|...||:|.||.:|
  Fly   466 --LRVLGTYL-----HRYAGLHADELPKDTKPLTLLVGMQVNAFYYNLDNSVYVMAGVLHPPAYH 523

Human   576 PGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDNH--------------------ALQEAH 620
            ..:|.::.||..|.::.|||.|.|            |..                    ..||..
  Fly   524 RSWPDSLKFGTIGYLIGHELTHGF------------DTEGSSFDSAGEVRDWWSRKSEAVFQERA 576

Human   621 LCLKRHYAAFPLPS-RTSFNDSLTFLENAADVGGLAIALQAY---SKRLLRH--HGETV------ 673
            .|...::..:.:|. ..:...:.|..||.||.|||..||..|   .|:|.|.  .|||:
  Fly   577 QCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRNHMKQLQRSGADGETLAHKNEQ 641

Human   674 LPSLDLSPQQIFFRSYAQVMCRKPSP----QDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGAL 734
            :|.|||||:|:||..:||:.|....|    ::....|:....||.|.:|:...||..::|..|:.
  Fly   642 MPGLDLSPEQLFFVGFAQLWCADYEPEHYWEELTGAHTVDKYRVLGAVSNNDDFAEVYKCPLGSP 706

Human   735 LNPSSR-CQLW 744
            ::|.:. |::|
  Fly   707 MHPKAESCRMW 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KEL	XP_005250050.1	M13	109..742	CDD:341056	170/737 (23%)
Nep7	NP_651603.1	M13	66..715	CDD:341056	170/737 (23%)