Protein Alignment KEL and Nepl16

DIOPT Version :10

• Sequence 1: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Alignment Length: 783
• Identity: 152/783 - (19%)
• Similarity: 265/783 - (33%)
• Gaps: 226/783 - (28%)

Human    55 AVARRVLT-AILILGLLLCFSVLLF--------------YNFQNCGPR-----PCETSVCLDLRD 99
            ||.:..:| |.|::..||..|.:||              .:...|.|.     .|...:|..:..
  Fly   101 AVHKMAITSATLLVTTLLVASPILFLISTAPSPLPRDCYMDGDRCSPAVSAPPECSDPICEAVAS 165

Human   100 HYLASGNTSVAPCTDFFSFACGRAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFY 164
            ...|..|.:..|||:|..|:|.|           .|.||| :..::|:.|| ......:..:.|.
  Fly   166 SIQARLNWNKDPCTEFKKFSCWR-----------NTPNKN-ITNLIEMGNS-QKSVDSQMLYLFQ 217

Human   165 NSCM-----------DTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPF 218
            |..|           ::...:...:..:.::.:.|||:...|   |:..:....|:...|.
  Fly   218 NKIMNGSFGILHNLFESCLQQTTNSTVMHRIFDSLGGYLPVG---SVGPSSIAPLIAKIYD---- 275

Human   219 FRAYLGPHP------------------------------------ASPHTPVIQIDQPEFDVPLK 247
                |||.|                                    .||..|..:|.|   .||
  Fly   276 ----LGPSPLVDLYHDLSYGRRPHILLIISGPSTSSTILERKIRWMSPKAPPSRIRQ---GVP-- 331

Human   248 QDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQ------RRA 306
                 |:.|.:...:|.|.          .|..|.     :|....:|:|::.|.:      ||.
  Fly   332 -----KLLADLIENFLPYF----------VSYAQR-----VSEKDTIFEFIKDLNKLQVEHSRRG 376

Human   307 QGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLK--------------- 356
            ......:..:..|:::.|.::|...:...:       |..:||.:.:|||
  Fly   377 FWDSTVLYNVSSLQDLYPVLNWTLLIPQNW-------SGPIVVRNSDYLKALEYFLTKYPTRVAH 434

Human   357 NMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMK 421
            |...|:..:.:..||:....:.....:...|.|.|....|:.. |:.|::.|::..:
  Fly   435 NSLLLLSALQILPRDYPSPEVCTRSTMWALPELSSSLYIAQHS-SEDLKDTTKRAEI-------- 490

Human   422 CVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQ 486
                   .|: :|.|...|   .||.:.||:...:|:      ::::..|   |..:...|.:..
  Fly   491 -------IFK-SLKAHLKR---APSLKGAALVKLSAL------KIQSQTW---EGFSNTTDLLKS 535

Human   487 LQVEMGASEWALKPELA-----RQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKV 546
            ||.....||...:..|.     :.|.|||.|...                         .|....
  Fly   536 LQPLNITSECWFQNILEIYKKNKLEPNDISLNGG-------------------------SHDAWA 575

Human   547 SPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLAC 611
            .|.....:|....|.:|.|..::..|:|:...|..:::.:.|..:|.|:|....:        :.
  Fly   576 YPIVSTIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEILRSITK--------SF 632

Human   612 DNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPS 676
            |..|::    |:......|...||         ::.....||:.|:..:.........|...||.
  Fly   633 DEKAMR----CVPHSVNIFSNYSR---------MDILIHSGGMQISYHSMLSLTGPIKGMARLPG 684

Human   677 LDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFA-RYFRCARGALLNPSSR 740
            |:|:|.||||...||.:|.: |.....||::|....:.|.|.:....| ..|:|..|:::|....
  Fly   685 LNLTPTQIFFLVSAQELCAE-SNYLGIDTNAPEFDNILGWLVAQGGSATEVFKCPSGSMINVQKT 748

Human   741 CQL 743
            |.:
  Fly   749 CNV 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KEL	XP_005250050.1	M13	109..742	CDD:341056	135/706 (19%)
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	135/705 (19%)