Protein Alignment KEL and Nepl15

DIOPT Version :10

• Sequence 1: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_651098.2
• Gene: Nepl15 / 42701
• FlyBaseID: FBgn0039024
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 776
• Identity: 172/776 - (22%)
• Similarity: 280/776 - (36%)
• Gaps: 193/776 - (24%)

Human    65 LILGLLLCFSVLLFYNFQNCG-----PRPCETSVCLDL-----RDHYLA-SGNTSVAPCTDFFSF 118
            |:||.:| ||:        |.     |.|...:..:|:     ..|..| .|:.....|.:|:::
  Fly     8 LLLGAIL-FSI--------CAIDASVPHPLAANYSIDILRLAKAAHIKAYMGDEKEQACNNFYNY 63

Human   119 ACG---------RAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIE 174
            ||.         ::|...|..:||......:...:|:........|.:.:...||.||.......
  Fly    64 ACANWPRLHPARKSKTRTNYLEELQELYIRKSADMLKSATRGAENSADRQLKYFYGSCRLQTNDT 128

Human   175 AAGTGPLRQVIEELGGW---RISG------KWTSL--NFNRTLRL-------LMSQY-------- 213
            .:....|:.|.:..|||   |::.      .|..:  |..|.|.:       ::..|
  Fly   129 RSALNTLQNVTDFRGGWPEIRVASWYQYEYDWLQVVANLKRKLGVDIFIGLEVILDYKEEKMHRL 193

Human   214 ----GHFPFFRA-YLGPHPASPHTPVIQIDQPEFDVPLK---QDQEQKIYAQIFREYLTYLNQLG 270
                ..||..|. ||.||.....    :|.:...:..||   .:|.:....::..:.:....||.
  Fly   194 KIGAPQFPMSRRHYLHPHFEGTR----EIYERSIENKLKLYFPEQSEHWRQEVASQVVQIEQQLA 254

Human   271 TLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPA----IDWLSC 331
            ..|..:|       :|:::.|:|         ||.|             .||..|    :|....
  Fly   255 KGLPHNP-------ALTLAQTTR---------QRTA-------------AEMKTAYGSYVDVTRY 290

Human   332 LQATFTP---MSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQF 393
            ||..|..   |.|..:..      :|:.|:..::.|                     :|.|
  Fly   291 LQLIFNDNLYMDLYETPE------DYMSNLVDVIRE---------------------TPKL---- 324

Human   394 QEARRKLSQKLRELTEQPPMPARPR---WMKCVEETGTFFEPTLAALF---------VREAFGPS 446
            |.|...:.:.| |..:...:||..|   |  ||:....||...|.:||         :.|.  .|
  Fly   325 QLANYTMWKAL-EALDIARVPASQRADIW--CVQLAQQFFPHQLESLFHRNYNHMQMINEL--QS 384

Human   447 TRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQ 511
            |.|...::|   |:.|....| |.|:..||:..|..|:..|::.....:   ..:|.||.:..|.
  Fly   385 TWSDIKRVF---REDLQASER-LLWLTLETRQKAITKLEALKLHFRTHD---DNKLIRQMHGLIL 442

Human   512 LGSSFLQSVLSCVRSLRAR-IVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFF- 574
            ....|..:::|.::....| :.:...:|..:......|     :|.:..:.:..|...||..||
  Fly   443 NMDRFYPNLVSVLQWKTQRGLAKLMTEPVAEDEVHKLP-----HYEIQKNRIQVPITFLQARFFW 502

Human   575 HPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACD---------NHALQEAH----LCLKRH 626
            .|.||..:.:...|.::|.::||.|     .|.....|         :|..:.::    .|.:..
  Fly   503 DPAYPNGLKYATLGVLLARQMLHGF-----DGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQ 562

Human   627 YAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETV-------LPSLDLSPQQI 684
            ||.|.........|........||.|.|.||.:|| ::.|::..||.       ||.||....||
  Fly   563 YAIFVEYKGKPVQDKDLLRRIVADNGALDIAYRAY-QQWLKNAAETPVIYQRERLPLLDHDHNQI 626

Human   685 FFRSYAQVMCRK-PSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 744
            |:..|||:.|.. |...:..| ..|..|||:..||::..||..:.|:|...||...:|.|:
  Fly   627 FYLGYAQLYCTDYPETVERFD-ELPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KEL	XP_005250050.1	M13	109..742	CDD:341056	157/717 (22%)
Nepl15	NP_651098.2	M13	56..684	CDD:341056	157/715 (22%)