Protein Alignment KEL and Nepl12

DIOPT Version :10

• Sequence 1: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Alignment Length: 728
• Identity: 162/728 - (22%)
• Similarity: 281/728 - (38%)
• Gaps: 179/728 - (24%)

Human   106 NTSVAPCTDFFSFACGRAKETNNSFQELATKNK------------NRLRRILEVQNSWHPGSGEE 158
            |.||.||.:|:.:|||..:..........:::.            .:|...:::..:.:..|...
  Fly    65 NQSVEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELA 129

Human   159 KAFQFYNSCMDTLAIEAAGTGPLR-------QVIEELGGW-RISG-KWTSLNFN-RTLRLLMSQY 213
            .|.:|||:|:      .|...|..       .:|..:||: .:.| .|.:.||| ..:...::.|
  Fly   130 VAQRFYNACL------GANLHPFNAADPAYLSLIRSIGGFPAVDGDAWKASNFNWINMSAHLANY 188

Human   214 GHFPFFRAYLG-PHPASPHTPVIQIDQPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDP 277
            |.....|..|. .:|..|:|.:     ||                               ||.|.
  Fly   189 GANGLIRETLQLRYPFEPYTKL-----PE-------------------------------LGFDH 217

Human   278 SKVQEHSSLSIS-ITSRLFQFLRPLEQRRAQGKLFQM-VTIDQLKEMAPAI--DWLSCLQ----- 333
            ..|.|.   :|| .|:|.|:    |.:.|..|.|... :..|:::|....:  .|...|:
  Fly   218 IIVHEE---NISRNTTRAFR----LNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQC 275

Human   334 ATFTPMSLSPSQSLVVHDVEYLKNMSQL----------------VEEMLLKQRDFLQSHMILGLV 382
            ..|.|..:    ..|....||..|:|..                ::::..:.|..:.:::.:.|:
  Fly   276 EVFDPYRI----KRVFPQSEYYYNISWSGLHSTNKLFCDFYYVELDKVCARHRKAVANYLAMKLL 336

Human   383 VTLSPALDS---QFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFG 444
            ....|.|.:   |.......|.|.:|.|..:                          |::...|.
  Fly   337 YRFDPKLKAPRYQRNYCSVTLYQSMRFLFNK--------------------------LYMANNFS 375

Human   445 PSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGA-SEWALKPELARQEYN 508
            .:.|....::...:|.:|...|.:..|::.|::..|..|.:::|..:|: .:.||...:.| |.|
  Fly   376 EAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIR-EIN 439

Human   509 DIQL-------GSSFLQSVLSCVRSLRARIVQSFL-QPHPQHRWKV-SPWDVNAYYSVSDHVVVF 564
            .:::       .:..||.::..:....:|..|... ...||   |: :...|.|.|...|:.:..
  Fly   440 SLKVIEDRYAETNINLQHLVVQINRFSSRHFQELTNDTKPQ---KILTGLQVGAGYYTPDNSINV 501

Human   565 PAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIF------------YQLLLPGGCLACDNHALQ 617
            .||:::||.:....|.::.||..|.|:.|||:|.|            .:.||.    .....||:
  Fly   502 MAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLS----EISQQALE 562

Human   618 EAHLCLKRHYAAFPLP--SRTSFNDSLTFLENAADVGGLAIALQAY---SKRLLRHHGE----TV 673
            :...|...:|..:.:|  || ..|...|..||.||..||..||.||   .::||.|.|:    ..
  Fly   563 DRAECYMDYYGKYQVPEISR-RVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDA 626

Human   674 LPSLDLSPQQIFFRSYAQVMCRKPSPQDSH------DTHSPPHLRVHGPLSSTPAFARYFRCARG 732
            :|.|||:|:|:||..:||:.|  ...::.|      |.|:....||.|.||::..|...:.|:.|
  Fly   627 MPGLDLTPEQLFFLGFAQLFC--SHYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVG 689

Human   733 ALLNPSSR-CQLW 744
            :.:.|.:: |:||
  Fly   690 SGMRPGAKTCRLW 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KEL	XP_005250050.1	M13	109..742	CDD:341056	157/721 (22%)
Nepl12	NP_649924.1	M13	68..700	CDD:341056	157/721 (22%)