Protein Alignment KEL and Nepl10

DIOPT Version :10

• Sequence 1: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Alignment Length: 735
• Identity: 147/735 - (20%)
• Similarity: 273/735 - (37%)
• Gaps: 179/735 - (24%)

Human    69 LLLCFS-VLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGR---AKETNNS 129
            ||||.. |.||...|........||  .|:.::.    |.:.:|||:|::|||||   |.:..::
  Fly     5 LLLCSCLVALFIPIQAIVDINVATS--NDIHNNL----NRTTSPCTNFWNFACGRFSSASKYVDN 63

Human   130 FQELATKNKNRLRRILEVQNSWHPGSGE-------EKAFQFYNSCM-DTLAIEAAGTGPLRQVIE 186
            |:.:..:....:...:|.    |.|..:       ::..|:|.:|. ||..:.  |.....:::.
  Fly    64 FERVEDQFATAMVEFMES----HLGENDTLAPRLIKQMRQYYKACKEDTRKLH--GNPRPEELVN 122

Human   187 ELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQE 251
            :   |.:..|    .|     |:....|.|...|..:..:.:...  |||:..|:   |..:..:
  Fly   123 Q---WILHPK----KF-----LVYGLNGVFIDERVDVAANDSMRW--VIQLRMPD---PADRYSD 170

Human   252 QKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQR-RAQGKLFQMVT 315
            ::: .|:.|.|                   |.:..|:.:. :|.:.:..|:.: ||:..:....:
  Fly   171 RRV-LQLMRLY-------------------EEAWYSMGVV-KLVEKMHQLQDKYRAEYPVVYTWS 214

Human   316 IDQLKEMAPAIDWLSCLQATF--TPMSLSPSQSLV-----VHDVEYLKNMSQLVEEMLLKQRDFL 373
            ..:|::..|       :..:|  ..:.::.::.|.     |.|||||:...:.:.:...:.:|
  Fly   215 FSELRQEIP-------IPHSFFIELLGVNHTEELYHLTFEVSDVEYLRECFRCLRDFASEPKD-- 270

Human   374 QSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALF 438
                              .:..||:.:.     :.|..|....||  .|:.....:.  .|...:
  Fly   271 ------------------TYIRARQYVL-----VEESEPRERNPR--SCIHHMRAYL--PLGMNY 308

Human   439 VREAFGPSTR----SAAMKLFTAIRDAL-----ITRLRNLPWMNEETQNMAQDKVAQLQVEMGAS 494
            :.:.|....|    |..:::.:.::.|.     ..||:..|  |:.....|  |:..:|:::|..
  Fly   309 IYDRFIYQNREEDTSKVLEILSTLKAAFGQYLDANRLQLTP--NQLAYVRA--KLEGIQIKIGNL 369

Human   495 EWALKPELARQEYNDIQL-GSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVS 558
            .....||.....|..... .::||.::|... :||.|:..:.|..      :.|..|:..|| |:
  Fly   370 PEEKSPEFYNNHYGSANFSATNFLANLLEAF-ALRTRLQNAGLLA------RNSRVDLRHYY-VN 426

Human   559 DHV---------------VVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQ--LLL-- 604
            |:|               :..|...||.|.|.............|:::.||:.|.|.|  :|.
  Fly   427 DNVRKARTSPFYENERNTITVPMEFLQWPLFDHREHTIFQHSLLGAVLGHEMNHAFEQEGILFDA 491

Human   605 -----PGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAY--- 661
                 |.|....::...::|..|.:..    |.         ::..|..||:.||.:|..|:
  Fly   492 AGNESPVGLEIRESKPFRDAIKCAEEQ----PF---------VSLKERLADLNGLQLAYDAFFGL 543

Human   662 --SKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFA 724
              ..|...:.....  ..:.:..|:|..||||..|....|..:||....   ||:..:.:...||
  Fly   544 AHDSRQFEYRPYAF--EQEFTAPQLFHLSYAQFFCGSLPPVIAHDRDDE---RVNVSVGNLRQFA 603

Human   725 RYFRCARGALLNPSSRCQLW 744
            ..|.|.    .:|||.|::|
  Fly   604 YDFNCE----TSPSSVCEMW 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KEL	XP_005250050.1	M13	109..742	CDD:341056	133/690 (19%)
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	129/676 (19%)