Protein Alignment KEL and Nepl6

DIOPT Version :10

• Sequence 1: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Alignment Length: 744
• Identity: 146/744 - (19%)
• Similarity: 254/744 - (34%)
• Gaps: 224/744 - (30%)

Human   101 YLASGNTSVAPCTDFFSFACGR--AKETNNSFQELATK-----NKNRLRRILEV-QNSWHPG--- 154
            |:|..:::   |..:|.:|||:  .:..::.|.|:...     |.|.::.:.|: |.|..||
  Fly    36 YVAEDSSA---CGTYFQYACGKYAVRHRDDPFTEIIQMLDHKVNGNLVQLMHELHQRSQSPGFNE 97

Human   155 -SGEEKAFQFYNSCMDT----------LAIEAAG---TGPLRQVIEELGGW-RISGKWTSLNFNR 204
             |.|.|...||.:|.:.          |.:...|   |.|  |.:.....| :...||
  Fly    98 SSVEAKVLHFYRTCREAPPSTRKMEHYLRLAPPGQALTWP--QFMPRGEPWPKAQFKW------- 153

Human   205 TLRLLMSQYGH---FPFFRAYLG--PHPASPHTPVIQIDQPEFDVPLKQDQEQKIYAQIFREYLT 264
                 |...||   :.|....:.  ...:|.::...::|   ..:|..:...|.:..
  Fly   154 -----MKSLGHLYRYGFTNVLVNVLVLRSSENSNRFRLD---ISMPSLEGDAQHLGG-------- 202

Human   265 YLNQLGTL-LGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQ--------LK 320
            :|:.|.|| :.|.|:|             .:...:|.:  ||.:..:..:..:|.        |:
  Fly   203 FLSTLATLQIIGVPTK-------------SILPLVRKI--RRLESAIRVLTEVDDDDESETWTLR 252

Human   321 --EMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVE----EMLLKQRDFLQSHMIL 379
              |......|...:: :....|:|....:...:.:|...:.:|::    |::   .:::.:..:|
  Fly   253 QWEYKTGYAWQGFVE-SIVGHSVSHHYVMQAQNAKYFTGLKRLMDSTDAEVV---ANYIMTRFVL 313

Human   380 GLVVTLSPALDSQ-----FQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFV 439
            .|:   ...:||.     ..:.||.::.....|.::                 .|.:|.....:.
  Fly   314 YLI---DDFIDSNEHIDCVTDMRRNMNLASNLLYKE-----------------RFLDPATLQQYT 358

Human   440 REAFGPSTRSAAMKLFTAIRDALITRL-RNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELA 503
            :|         ..|:|..:|...:.:: .|...:..|..:|...|...:.:.:|        .|.
  Fly   359 QE---------VTKVFEQLRRQFLLQINENRLGLTSEQNSMVATKAQHVVLNIG--------NLP 406

Human   504 R---------QEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQ-----PHPQHRWKVS----PWD 550
            |         :.|.|:.............:..|..|..:..||     |.|...:.:|    ...
  Fly   407 RGRDHRSFVSRHYEDLVFPLPDFDYAREHLNLLEFRTRKQVLQLNQSAPTPDEFFYLSDPKTAMS 471

Human   551 VNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLH------IFYQLLLPGGCL 609
            ...||.:..:::|.|.||||.|||.........:...|.::||||:|      ::|
  Fly   472 SGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMHSVDTVGLYY--------- 527

Human   610 ACDNH------------------ALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAI 656
              |.:                  .||    ||.|        :.|.:.|     |..||:.||.:
  Fly   528 --DRYGNIHEIGPQISSSPRFVAGLQ----CLNR--------NSTQYLD-----ERIADIAGLDL 573

Human   657 ALQAY----SKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQD--SHDTHSPPHLRVHG 715
            |...|    |:..|...  |.:|     ||||||.:.||..|....|.:  .||.   ...|:..
  Fly   574 AYSTYFQNSSQMSLTDF--TTIP-----PQQIFFLNLAQFFCGDGDPINFVGHDN---DETRLQQ 628

Human   716 PLSSTPAFARYFRCARGALLNPSSRCQLW 744
            .|:....|...|.|.  |..|...:||||
  Fly   629 MLNGFAPFHEAFGCP--AKSNQPEKCQLW 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KEL	XP_005250050.1	M13	109..742	CDD:341056	140/732 (19%)
Nepl6	NP_609023.3	M13	47..653	CDD:341056	139/726 (19%)