Protein Alignment KEL and Nepl4

DIOPT Version :10

• Sequence 1: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_609019.1
• Gene: Nepl4 / 33889
• FlyBaseID: FBgn0031805
• Length: 652
• Species: Drosophila melanogaster
• Alignment Length: 775
• Identity: 172/775 - (22%)
• Similarity: 287/775 - (37%)
• Gaps: 209/775 - (26%)

Human    56 VARRVLTAILILGLLLC-FSVLLFYN--FQNCGPRP----CETSVCLDLRDHYLASGNTSVAPCT 113
            :.:.:.||:|:||...| .||.:..|  .|:|   |    |.:::.....|..::..::...||.
  Fly     1 MVQNLWTALLLLGSATCGSSVPVKANDPEQSC---PYLGECNSTINQQHIDTLMSYVDSEKNPCE 62

Human   114 DFFSFACG--RAKETNNSFQELATKNK-NRLRRILEVQNSWHPGSGE------EKAFQFYNSCMD 169
            ||:::|||  |||..:::...:.:::: ||....|.:|...:|.:.|      .|....|.||
  Fly    63 DFYAYACGKWRAKHGSHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYPMFAKVLAHYQSC-- 125

Human   170 TLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLL--MSQYGHFPFF-----RAYLGPH- 226
             :|:|..   .||:.||.|....::    |||....:.||  :.:||:...:     |.|...|
  Fly   126 -IALEKP---DLRRYIELLDRDLLA----SLNSTHWMHLLAALGRYGYHGHYVQVEVRWYNATHH 182

Human   227 -----PASPHTPVIQIDQPEFDV---------PLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDP 277
                 |.:.|.. :.:.|..:|.         ||.|.|||      ||
  Fly   183 MIFLLPHNRHLN-LSLTQDIYDALSQDGSSWPPLHQLQEQ------FR----------------- 223

Human   278 SKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLS 342
                       |:...|.:..:|    .:....|:..::||::...|.:.|...|: |....|:.
  Fly   224 -----------SLEQNLVRLAKP----HSADDTFRNYSLDQIRTEVPGLHWDEALR-TQLGRSVP 272

Human   343 PSQSLVVHD-------VEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKL 400
            .:....|.|       ||||..    |:.:||.                            |..|
  Fly   273 GNHVFQVDDLDAIEGLVEYLNT----VDTLLLN----------------------------RYSL 305

Human   401 SQKLRELTEQPPMP-------ARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKL---- 454
            ::.|..|.|.|..|       .|.|...|:..........:..::.|..:  |.|..|.:|
  Fly   306 ARFLSHLLELPHNPLATWESGQRSRGRNCIRHMRRSVYLPMNYVYERSFY--SRRRHADELVIHS 368

Human   455 -FTAIRDALITRLRNLPW-MNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDI----QLG 513
             |..::..|..|:::..: ::::.....|.||.|:::.:|    .|.|.:..|.|.|.    .:|
  Fly   369 VFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVG----NLPPNVTEQFYWDSDRRWSVG 429

Human   514 SSF----LQSVL---SCVRSLRAR-------IVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVF 564
            ..|    |.|:|   :.|..|.:.       |..||....|:....:   |...|:....:::..
  Fly   430 RDFYENHLNSLLYYYTLVADLESSSDQEERDIWYSFNMHTPEFPDNI---DATPYFYCLGNIIFV 491

Human   565 PAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLL---PGGCLACDNHALQEAHL----- 621
            |...::.|||...:..|:.:|...:.:.||::|.|...|:   ..|.|...:..|.|..|
  Fly   492 PYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNLRNFSDQLGEVELYNGAV 556

Human   622 -CLKRHYAAFPLPSRTSFNDSLTFL-ENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQI 684
             ||               |.|...| |..:||.|..:|:|.|....|...|.          .::
  Fly   557 GCL---------------NSSAVMLNERTSDVSGSRLAMQTYGGDWLTRSGN----------GRL 596

Human   685 FFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 744
            :|..:|...|.....| .||:.|.   |::..|...|.||..|||..|:.:..:.:|..|
  Fly   597 YFLQFAHFFCGDEGDQ-YHDSGSQ---RLNYALGQVPQFAEVFRCHVGSGMTSADQCPFW 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KEL	XP_005250050.1	M13	109..742	CDD:341056	156/711 (22%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:472708	156/709 (22%)