Protein Alignment KEL and Nep6

DIOPT Version :10

• Sequence 1: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_572831.2
• Gene: Nep6 / 32234
• FlyBaseID: FBgn0030425
• Length: 655
• Species: Drosophila melanogaster
• Alignment Length: 762
• Identity: 162/762 - (21%)
• Similarity: 274/762 - (35%)
• Gaps: 199/762 - (26%)

Human    64 ILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNN 128
            ::|||::|         .:....:.|:..:..|.        :..|.||.:|..:|||. ..:|.
  Fly    12 VVILGVML---------LKLAAAQDCQQQLDNDT--------DAEVKPCENFHQYACGN-WYSNT 58

Human   129 SFQELATKN---------KNRLRRILEVQNSWHPGSGEEKAF-------QFYNSCM--------D 169
            |.:.|...:         |.:|.|.||..:|....|......       ..|..|:        .
  Fly    59 SQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQSIRTY 123

Human   170 TLAIEAAGTG-PLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTP 233
            |.|:..:|.. ||  :....||   |..|...|      ..:..||....:|..:..:..|....
  Fly   124 TDALSRSGANFPL--LANHTGG---SFDWVLAN------AALRTYGAQGLWRLLVKDNWQSADQR 177

Human   234 VIQIDQPEFDVPLKQDQEQKIYAQIFREYL-TYLNQLGTLLGGDPSKVQEHSSLSISITS--RLF 295
            :..:..|:||: |.:|.|...:  :::.|| ..|.:||.       :|:..:.|:..:.:  :..
  Fly   178 IFYMLPPKFDL-LGRDDELNEF--LYQRYLKILLLELGL-------RVRRAALLAEKLVAFEKSL 232

Human   296 QFLRP------LEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEY 354
            |.|.|      |..|:.|       ::..|:...|.::.....:.....:.......|:|.|::|
  Fly   233 QKLLPNDAEQTLVLRKPQ-------SLKDLESQLPRLELKRYFETILEGIDWDSKTLLLVADLDY 290

Human   355 LKNMSQLVEEMLLKQRDFLQSHMILGLVVTLS-PAL-------DSQFQEARRKLSQKLRELTEQP 411
            |:.:.:|:.|       .....|:|...:.|. ||.       |.:....|....::||:|
  Fly   291 LQGLQRLLAE-------HTSDPMVLSTWLLLQLPAYFELRLHDDDKLGNQRNHCLEQLRKL---- 344

Human   412 PMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEE- 475
             ||.:...::.....|..::         :.:..:.:..|: ||..::......|......||:
  Fly   345 -MPGQLGRLQMQLVLGESYQ---------DVYDTAIQQIAV-LFRDLKQQFELVLNETEVFNEDL 398

Human   476 -TQNMAQDKVAQLQVEMGASEWALKPELARQEYN----DIQLG----SSFLQSVLSCVRSLRARI 531
             |:|:|:||:..:::        |.|.| :...|    ..|||    ::.||..||     :|::
  Fly   399 VTRNLARDKLRAMRL--------LTPRL-QDPINGGPGTPQLGGNCDANLLQLSLS-----QAKL 449

Human   532 VQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFH-----PGYPRAVNFGAAGSIM 591
            ....:...|.......|..|||||.:..:.:..|.||:..|...     ....||......|.|:
  Fly   450 EYRQVFGEPVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQCSKEADTRAKLSAGLGYIL 514

Human   592 AHELLHIF-----------------------YQLLLPGGCLACDNHALQEAHLCLKRHYAAFPLP 633
            |||::|.|                       .:..|..||.                      |.
  Fly   515 AHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCY----------------------LG 557

Human   634 SRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHH-GETVLPSLDLSPQQIFFRSYAQVMCRKP 697
            .|.| |.:||..||.||..||.:||..|     ||. |.|.|        :.||.::||..|...
  Fly   558 VRYS-NATLTVNENIADTEGLRLALDTY-----RHRSGATNL--------RTFFVAFAQNWCGTV 608

Human   698 SPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 744
            :.......|:....||:..:.:.|.|...|.|...:.:||.::|.:|
  Fly   609 ASTSGLSQHAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KEL	XP_005250050.1	M13	109..742	CDD:341056	154/713 (22%)
Nep6	NP_572831.2	M13	40..653	CDD:341056	154/713 (22%)