Protein Alignment KEL and Nep1

DIOPT Version :10

• Sequence 1: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_511056.2
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Alignment Length: 810
• Identity: 215/810 - (26%)
• Similarity: 371/810 - (45%)
• Gaps: 94/810 - (11%)

Human    18 QSEEEPRERSQ-------------AGGMGTLWSQESTPEERLP--VEGS---RPWAV-----ARR 59
            |.:::.:::.|             :||:|.   |...|.:..|  |.|:   ..|.:     .||
  Fly    51 QMQQQQQQQQQNKLPTVVFLAPDGSGGVGI---QRGNPAQGNPGMVTGTGSHSDWLLKESQQRRR 112

Human    60 VLT---AILILGLLLCFSVLLFYN-FQNC---------GPRP------------------CETSV 93
            :|.   |..:||..:....:.|.: .|.|         ..||                  |.|..
  Fly   113 LLVLAIAFTVLGAAIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQDSGSAHEGQDNICMTQE 177

Human    94 CLDLRDHYLASGNTSVAPCTDFFSFACG---------RAKETNNSFQELATKNKNRLRRILEVQN 149
            |:......|::.:.:..||.|||.:|||         ..:.:.::|:.|:.:.:..||.:||...
  Fly   178 CVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAVLEEPI 242

Human   150 SWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWR-ISGKWT---SLNFNRTLRLLM 210
            .........||..|:.||||...|...|||.|:||::.||||. |...|:   .|:..|.:..|.
  Fly   243 DERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWSPPADLSVERLMGQLR 307

Human   211 SQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGG 275
            ..|........|:|....:....::|:||.::.:|.:....::..|...|.|..|:.|:..|||.
  Fly   308 LNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDRRAYHRYMTQVALLLGA 372

Human   276 DPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTP-M 339
            ||:.........:...::|.....|...|.....:::.:.:.:|:|:.|.:.|...|||...| :
  Fly   373 DPATAAAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQAALGPGI 437

Human   340 SLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKL 404
            .|...:.||.:.:.||..|.:::..   ..|..:.::|:..||::|...:..::|..|.:..:.|
  Fly   438 PLQEDEPLVTYGLHYLTEMGKILAH---TDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKIL 499

Human   405 RELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNL 469
            ..:..:     |.||.:|||.|.......:.|||:|:.|...::..|:::...||.|....|...
  Fly   500 MGIQSE-----RTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLAEN 559

Human   470 PWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQL-GSSFLQSVLSCVRSLRARIVQ 533
            .||::||:.:|::|...:...:|..|.........|||.::.: ..:|:.:|||.::....::::
  Fly   560 DWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLR 624

Human   534 SFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHI 598
            ...||..:.:|...|..|||:|:.:.:.:|||||:|||.|:...:|:::|:|..|.::.||:.|.
  Fly   625 LLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHG 689

Human   599 F----YQLLLPGGCLACDNHALQEAH----LCLKRHYAAFPLPSRTSFNDS-LTFLENAADVGGL 654
            |    .|....|..:...|:|..||.    .|:...|:.:.:.....|.|. :|..||.||.|||
  Fly   690 FDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGL 754

Human   655 AIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDS-----HDTHSPPHLRVH 714
            ..|.:||.|....|..|..||.|:::..|:||.:|||:.|....|:|:     ...|||..:||.
  Fly   755 KQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVL 819

Human   715 GPLSSTPAFARYFRCARGALLNPSSRCQLW 744
            ||||::..||..::|..|:.:||:.:|.:|
  Fly   820 GPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KEL	XP_005250050.1	M13	109..742	CDD:341056	187/661 (28%)
Nep1	NP_511056.2	M13	194..847	CDD:341056	187/660 (28%)