Protein Alignment CG4622 and ZCCHC8

DIOPT Version :10

• Sequence 1: NP_611929.1
• Gene: CG4622 / 37919
• FlyBaseID: FBgn0035021
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_060082.2
• Gene: ZCCHC8 / 55596
• HGNCID: 25265
• Length: 707
• Species: Homo sapiens
• Alignment Length: 686
• Identity: 175/686 - (25%)
• Similarity: 266/686 - (38%)
• Gaps: 230/686 - (33%)

  Fly    14 SVVIVDDDVEDG------------------ELEDDVVFVCP--EELTRKEIE---------PPTD 49
            |.::|:|...||                  |:|:.|..:..  ||..:.::|         |.:.
Human    81 SGILVNDTKLDGPILQILFMNNAISKQYHQEIEEFVSNLVKRFEEQQKNDVEKTSFNLLPQPSSI 145

  Fly    50 KIEEKHSNTSIQDTTEEDGDSLVFEVRFNKEA--------HFTSLQQQVLVALEGAFADK--QIV 104
            .:||.|.       .||.     ..::.||||        :||:.           ..||  |.:
Human   146 VLEEDHK-------VEES-----CAIKNNKEAFSVVGSVLYFTNF-----------CLDKLGQPL 187

  Fly   105 FRDNPQELMISAFERSRTLPEEEPQDLFLIDTQPAAKLNAANVPSYKRCNADILDEQTEERKKLK 169
            ..:|||  :...:|                            :|.|.:..:.|:..:.:| .::|
Human   188 LNENPQ--LSEGWE----------------------------IPKYHQVFSHIVSLEGQE-IQVK 221

  Fly   170 AEAVNKCFRPKAQSSCFNCGDTEHSLRDCTKPRNNSRITRARKKMTSR---------TERYHV-D 224
            |:      |||..  |||||..||.::||..|||.:||:..||:....         .:|||. :
Human   222 AK------RPKPH--CFNCGSEEHQMKDCPMPRNAARISEKRKEYMDACGEANNQNFQQRYHAEE 278

  Fly   225 TEQRFGHIRPGKISTKTRHAMGYSRGQLPFIFYRMRVLGYPPAWLEEAKVQSSGIALFNADGSEV 289
            .|:|||..:||.||.:.:.|:|.:...||...||||.|||||.||:||::::||:||:  ||.:.
Human   279 VEERFGRFKPGVISEELQDALGVTDKSLPPFIYRMRQLGYPPGWLKEAELENSGLALY--DGKDG 341

  Fly   290 TKSDEEEGE---SETFKYDVNKIVEYPGFNVQPKANCFDDFKHHNVPPFQESQSKENFIKSLGEN 351
            |..:.|.||   :::..||::|:|.|||||:.......|:::.....|.|..|.|:.|...|..|
Human   342 TDGETEVGEIQQNKSVTYDLSKLVNYPGFNISTPRGIPDEWRIFGSIPMQACQQKDVFANYLTSN 406

  Fly   352 -----VINGYKRKKLVDLPAPHDR---------VPAPSELLTSFDDYDMELEEETE-------DP 395
                 |.:|.||......|....:         .||..||     |.|||:...::       .|
Human   407 FQAPGVKSGNKRSSSHSSPGSPKKQKNESNSAGSPADMEL-----DSDMEVPHGSQSSESFQFQP 466

  Fly   396 PLPPSVPP--------------PQPPPP-----------------------EECED--------- 414
            ||||..||              |:..||                       ||.|:
Human   467 PLPPDTPPLPRGTPPPVFTPPLPKGTPPLTPSDSPQTRTASGAVDEDALTLEELEEQQRRIWAAL 531

  Fly   415 -------------------GELTARSPSPSLEDL-----KAQQEELLQELDVNA--SHNTTANES 453
                               |...|.||.|:..||     |..:::.|.|.:|..  :..:.|..:
Human   532 EQAESVNSDSDVPVDTPLTGNSVASSPCPNELDLPVPEGKTSEKQTLDEPEVPEIFTKKSEAGHA 596

  Fly   454 KSP----TDLDDTSETEVGPSAAESG---------NNEQSRSAPSTPFKASYEGTPLLKFSVYDR 505
            .||    |.|....:.|:.|...|..         |.:.|.......|.|  :.:|.....::..
Human   597 SSPDSEVTSLCQKEKAELAPVNTEGALLDNGSVVPNCDISNGGSQKLFPA--DTSPSTATKIHSP 659

  Fly   506 LPVGSNFKVGVSDVINFENLPDSTGKYEQMKDLLKN 541
            :|..|.|..|::. ..|||:.:|||.|.:::.||||
Human   660 IPDMSKFATGITP-FEFENMAESTGMYLRIRSLLKN 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4622	NP_611929.1	PSP	229..281	CDD:128850	25/51 (49%)
ZCCHC8	NP_060082.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..44
		zf-CCHC	227..244	CDD:395050	9/18 (50%)
		PSP	283..335	CDD:128850	25/51 (49%)
		RBM7 binding. /evidence=ECO:0000269|PubMed:27905398, ECO:0007744|PDB:5LXR, ECO:0007744|PDB:5LXY	286..299		4/12 (33%)
		RBM7 binding. /evidence=ECO:0000269|PubMed:27905398, ECO:0007744|PDB:5LXR, ECO:0007744|PDB:5LXY	309..324		10/14 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..518		23/113 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..607		15/75 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	641..660		3/20 (15%)
		MTREX binding. /evidence=ECO:0000269|PubMed:29844170, ECO:0007744|PDB:6C90	659..707		15/37 (41%)