Protein Alignment Brca2 and brca2

DIOPT Version :9

• Sequence 1: NP_611925.2
• Gene: Brca2 / 37916
• FlyBaseID: FBgn0050169
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: NP_001103864.2
• Gene: brca2 / 566758
• ZFINID: ZDB-GENE-060510-3
• Length: 2874
• Species: Danio rerio
• Alignment Length: 1100
• Identity: 208/1100 - (18%)
• Similarity: 383/1100 - (34%)
• Gaps: 308/1100 - (28%)

  Fly    37 NIIDEMAKICEA--DRQTFAIARRTRGHERL--AVDNSDFVAVEDL--ILSYAEP---------- 85
            |::|....:...  ...|.|: |:.:..||:  .:.||.    ||:  :...:||
Zfish   262 NVLDGAEDVLSIFFSNNTSAL-RKIKSKERIRKRITNSS----EDVKSVFLTSEPEQKLKADTET 321

  Fly    86 ------------TPEDQVEMIMSDFCSSPTYAEDED--EPSHESE-PWFRFRNKRIRTYSR---- 131
                        ||....|.|:::.|||.:..::.:  .||..:: ..|:|.::..:|..:
Zfish   322 KSPSKNDDSIEWTPLSLSETILTEGCSSTSLVDNNNTVAPSETNDGAIFKFTSESSQTCPQSVRL 386

  Fly   132 KRDP-----------KSHKAVQNEKRRGSSGLSVQRDLNTSFTSMACDF---------DASSQKI 176
            :..|           ||...:.|:|.|.........:::|:.|....|.         :..|.:.
Zfish   387 ESSPEGTQCQKILLDKSSAFMLNKKPRKFVYQVSSSEMSTTLTGSKADLPKCLDQTLKEGPSVEE 451

  Fly   177 HEVLLNLSQYFSATATASGPTPVPSQIDLPTEARQDSG---DECFNAELENLRDDLLQSGFTFEA 238
            ..|.||.|.:  ......|....|..::..:....|.|   .:...|..|....:::..|. .:.
Zfish   452 LSVCLNKSSF--TNENPIGDQTQPQAVEQLSSEHLDHGLDMTQLSKAFAEEFTQEIMAGGL-LDM 513

  Fly   239 SFYENEHEQEGP----------------GTMADTIYG--DSMQSVPTTRLRLESGKRNVWSDAD- 284
            ....|:..|..|                ..:||....  :...|:.|..:..:||....:||.|
Zfish   514 PVQSNQKVQVQPKAEPESKNKDGNHTDISNLADISVNSPNKSTSITTFEISHDSGCPTTFSDLDR 578

  Fly   285 STLKKADV-------EIAENKKLLM------------------------GQTQAKNVDIEENTNF 318
            :|...||:       :.|.||.:.:                        .||:.|:..:.|.
Zfish   579 TTASFADIGEYFPTFKTANNKFICIPTEAIVKAKASLDEAAGDGLAKTSNQTKPKHFHVTET--- 640

  Fly   319 ILEGIPLSEWLTPMELPEISKDVIKHIPDKKLKLEPSSQKEQKSSKD-SNASKV---RG------ 373
                              :.|.|.:.||..:..:..|......|... |:|||.   :|
Zfish   641 ------------------MCKSVSRSIPAPRPPVGQSIPSNHASGVSVSDASKTDSPKGFKMNFS 687

  Fly   374 --ASKQSCDINTKNEGTTILDQPNAAEQ-ENLLND--GELLEEFLFNDWQPMQCSNGPSTSKNAI 433
              :..||.:.:.|....||:...:|..| |:||.:  |...|            |:.|...|...
Zfish   688 NCSLPQSDESDCKTSSKTIITVSDAGLQTESLLKEKLGRSSE------------SSKPIHQKVDF 740

  Fly   434 QGPKENINSINLDDKEQP-----------EKQTPNKSQTISSHQLNGIRKKS--------FKFIE 479
            :...|.....::...::|           |..|...||.....:|..:.:::        :|...
Zfish   741 ERSAERHAVFDISSTQKPTAVDSSCDDLEENGTLTASQKADVTELCSLLEEANSQYEFTQYKSTN 805

  Fly   480 VSEEMKIKGEEFVDKVVSGL-YHFSHKCN-LRTEEYSDNHSQVMESTQCAEFKSAPSKPIEILDG 542
            :....:...:|:...:::.: :..|..|: ::.:..|..::..:.::....|:|         |.
Zfish   806 IGSHNRTTEKEWDPDILNDIDFDDSFSCDVVKGKHPSKTNASSVNTSDLISFRS---------DL 861

  Fly   543 KETYNAIAKVDVGE----INGKFSPL--NNDTIAEPEFCGFRTASNKAIPISEKMKIKTAEFMAE 601
            ||..|....:.|.|    ::|..|.|  ::|......| ||:||..|||.:|||...|...|..|
Zfish   862 KEKQNGTVVLSVTEESALVDGMRSILSKSSDNSHFHTF-GFKTAKGKAISVSEKSLNKAKHFFEE 925

  Fly   602 FQSKETIQQNDYLVHQPNDKPTSVGLDTAL---KRSIESSEEMRSKASKLVVVDTTMR------- 656
            ...:.|...   :::|.:.| |...:.|.:   ..:.::.:::|....::......:.
Zfish   926 DYKEATFTG---VINQEHFK-TESSVKTCISTENNNAQTKQDVRLSCGEVNAAHNMINWQEAGNA 986

  Fly   657 --EPH--QPTLDPVCRDLNESQFFGFRTASNKAIEITEAMEKRGAMFLAQSKATDQLNGWQPSDF 717
              ||:  :...|.||.|.|  ..|||.||....::::|...::..|||      :.::....|..
Zfish   987 GTEPNCLRDKTDVVCVDSN--IHFGFSTARGAKLKVSEKALEQARMFL------NDVDSIGESQT 1043

  Fly   718 PDVLPTSPNNEIHSINVENNKAVNTKTV------------------------------------- 745
            |.::|.|...  |.:::::.:...||.:
Zfish  1044 PKLVPRSSGK--HDVSMQSTRLQKTKDLCRGETSIKISQPDSGVANQISNGADITTFNSENVFQE 1106

  Fly   746 ----------------SETEF------FGFRTASNKGIVISENTKIKVAQFMSEFQAADASTDSN 788
                            |||..      :||:|||.||:.:..:. :|.|:.:  |:..|::.|:.
Zfish  1107 QKSGNAAKEVCEKISPSETSMPQPQQGYGFQTASGKGVSVLPSA-LKKAKAI--FKDCDSNIDNL 1168

  Fly   789 QPTVISEESRNIDAKFVDEAAAEDSANKP-TFCNVQSLKNTSDIEHFKHDFFVEHSAKEEHPLCS 852
            |.|.:.|....:|.:.|.:..|..|.:|. ||         ||:|.||.|..  ::..:|.|
Zfish  1169 QSTNMEERKTKLDVEIVKQTNALISNSKSVTF---------SDVEEFKTDLI--NNLDQEAP--- 1219

  Fly   853 QPLVRTPRRSQEIHSSLSQLAGKSPLDQATKKSVIARRNLLSLKRKRKIILSTETSTSCA 912
            |..|...:..|...|:|....|......|:.|.|.....  :|:|.:.::..:....|||
Zfish  1220 QKEVCELKGLQSEFSNLISSNGNCGFSTASGKKVSVSAE--ALQRAKDVLFESVDGFSCA 1277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Brca2	NP_611925.2	None
brca2	NP_001103864.2	BRCA2	900..925	CDD:279028	12/24 (50%)
		BRCA2	1009..1034	CDD:279028	8/30 (27%)
		BRCA2	1135..1160	CDD:279028	10/27 (37%)
		BRCA2	1239..1267	CDD:279028	6/29 (21%)
		BRCA2	1301..1325	CDD:279028
		BRCA2	1367..1392	CDD:279028
		BRCA2	1407..1430	CDD:279028
		BRCA2	1446..1476	CDD:279028
		BRCA2	1492..1517	CDD:279028
		BRCA2	1577..1602	CDD:279028
		BRCA2	1620..1648	CDD:279028
		BRCA-2_helical	2026..2212	CDD:286278
		BRCA-2_OB1	2215..2338	CDD:286226
		BRCA2DBD_OB2	2350..2597	CDD:239940
		BRCA-2_OB3	2600..2733	CDD:286227

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006415
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900