Protein Alignment Brca2 and Brca2

DIOPT Version :9

• Sequence 1: NP_611925.2
• Gene: Brca2 / 37916
• FlyBaseID: FBgn0050169
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: XP_038945468.1
• Gene: Brca2 / 360254
• RGDID: 2219
• Length: 3373
• Species: Rattus norvegicus
• Alignment Length: 1180
• Identity: 224/1180 - (18%)
• Similarity: 379/1180 - (32%)
• Gaps: 395/1180 - (33%)

  Fly    29 VSAAANRSNIIDEMAKICEADRQTFAIARRTRGH-------------------ERLAVDNSDFVA 74
            |:..:|:.| |....:..|.|      ...|:||                   :.|..::||.:|
  Rat   873 VTNESNKPN-IGSTVEFQEED------LSHTKGHSLKNSPMTVDRDLDDEQAGQVLITEDSDSLA 930

  Fly    75 -VEDLILSYAEPTPEDQVEMIMSDFCSSPTYAEDEDEPSHESEPWFRFRNK--------RIRTYS 130
             |.|..........:.|......||.|:.:.....|..:...:.|..|.:.        ..||.|
  Rat   931 VVHDCTKKSRNTIEQHQKGTADKDFKSNSSLYLKSDGNNDYLDKWSEFLDPLMNHKFGGSFRTAS 995

  Fly   131 RKRDPKSHKAVQNEKRRGSSGLSVQRDLNTSF-TSMAC-DFDASSQKIHEVLLNLSQYFSATATA 193
            .|....|...|:..|       ...:|:...: ||:.| |..::.|..::..|:....|...:..
  Rat   996 NKEIKLSEDNVKKSK-------MFFKDIEEQYPTSLDCIDTVSTLQLANKKRLSEPHTFDLKSGT 1053

  Fly   194 SGPTPVPSQI-----DLPTEARQDSGDECFN----------AELENLRDDLLQSGFTFEASFYEN 243
            :..|...||.     |..|..:..|..:.|:          ||:..|...|.:||..||.:.::|
  Rat  1054 TVSTQCHSQSSVSHEDTHTAPQMLSSKQDFHSSHNLTPSQKAEITELSTILEESGSQFEFTQFKN 1118

  Fly   244 EHEQEGPGTMADTIYGDSMQSVPTTRLRLESGKRNVWSDAD--STLKKADV-EIAENKKL--LMG 303
            ........|.|  :.|:.|..|.|.        ...|.|.|  ..|..:.| :|..|||.  |:|
  Rat  1119 PSHIAQNNTSA--VLGNQMAVVRTA--------SEEWKDVDLHLPLNPSSVGQIDHNKKFECLVG 1173

  Fly   304 QTQAKNVDIE----ENTNFILEGIPLSEWLTPMELP----------EISKDVIKHIPDKKLKL-- 352
            ..|:.:..:|    :||:..|   |:.|    ||..          .:|.:.::    |.:||
  Rat  1174 VKQSSSHLLEDTCNQNTSCFL---PIKE----MEFGGFCSALGTKLSVSNEALR----KAMKLFS 1227

  Fly   353 -------EPSSQ---------------------KEQKSSK--DSNASKVRGASKQSCDINTKN-- 385
                   |||::                     |:|.:.|  |..:||        |.:..:|
  Rat  1228 DIENISEEPSTKVGPRGFSSCAHHDSVASVFKIKKQNTDKSFDEKSSK--------CQVTVQNNK 1284

  Fly   386 EGTTIL---------------------DQPNAAEQEN------------LLNDGELLEEFLF--- 414
            |.||.:                     .|.||.:.||            .:|.|:  .:..|
  Rat  1285 EMTTCILVDENPENYVKNIKQDNNYTGSQRNAYKLENSDVSKSSTSGTVYINKGD--SDLPFAAE 1347

  Fly   415 -NDWQPMQCSNGPSTSKNAIQGPKENINSINL--------------DDKEQ--PEKQTPN----- 457
             .:..|..|:.........|   ||:::.:..              .||||  .:|...|
  Rat  1348 KGNKYPESCTQYVREENAQI---KESVSDLTCLEVMKAEETCHMKSSDKEQLPSDKMEQNMKEFN 1409

  Fly   458 --------KSQTISSHQLNGIRKKSFKFI-EVSEEMKIKGEEFVDKVVSGL----YHFS-HKCNL 508
                    |:..:|...||    ||...: :.:|::.:..:....|::.|:    .|.| ||.::
  Rat  1410 ISFQTASGKNIRVSKESLN----KSVNILDQETEDLTVTSDSLNSKILCGINKDKMHISCHKKSI 1470

  Fly   509 RTEEYSDNHSQVMESTQCAEFKSAPSKPIEILDGKETYNAIAKVDVGEINGKFSPLNNDTIAEPE 573
            ..::..:.|..:...:|....:..|...||                             :|.||.
  Rat  1471 NIKKVFEEHFPIGTVSQLPALQQYPEYEIE-----------------------------SIKEPT 1506

  Fly   574 FCGFRTASNKAIPISEKM--KIKT----------------------------------------- 595
            ...|.|||.|.:.|.::.  |:|.
  Rat  1507 LLSFHTASGKKVKIMQESLDKVKNLFDETQYVRKTTNFGHQESKPLKDREDYKERLTLAYEKIEV 1571

  Fly   596 ----AEFMAEFQSKET---IQQNDYLVHQPNDKPTSVGLDTALKRSIESSEEMRSKASKLVVVDT 653
                .|.|..|.||:|   .||||::..| .:..||.|....:..:||:..|
  Rat  1572 TASKCEEMQNFVSKQTEMLPQQNDHMYRQ-TENLTSNGSSPKVHGNIENKIE------------- 1622

  Fly   654 TMREPHQPTLDPVCRD---LNESQFFGFRTASNKAIEITEAMEKRGAMFLAQSKATDQLNGWQPS 715
                 ..|.:..:|:.   :.|.......|..::...:.|:...:|..:|.:..
  Rat  1623 -----KNPRICCICQSSYFVTEDSALACYTGDSRKTCVGESSLSKGKKWLREQS----------- 1671

  Fly   716 DFPDVLPTSPNNEIHSINVENNKAVNTKTVSETEFFGFRTASNKGIVISENTKIKVAQFMSEFQA 780
               |.|.|....||..:.            ..||.|.........:||. .|:|..:. :||.||
  Rat  1672 ---DKLGTRNTIEIQCVK------------EHTEDFAGNALYEHSLVII-RTEIDTSH-VSENQA 1719

  Fly   781 ADASTDSNQ-PTVISEES-------RNIDAKFVDEAAAEDSANKPTFCNVQSLKNTSDIEHFKHD 837
            :...:|.|. .:.:|..|       .|....|:.:..  ||..:|      .:|||..     :.
  Rat  1720 STLFSDPNVCHSYLSHSSFCHHDDMHNDSGYFLKDKI--DSDVQP------DMKNTEG-----NA 1771

  Fly   838 FFVEHSAKEEHPLCSQPLVRTPRRSQEIHSSLSQLAGKS-PLDQATKKSVIARRNLLSLKRKRKI 901
            .|.:.||.:|..|  .|........|::.::.|..|.|: .:|.       |..:|.:.|....:
  Rat  1772 IFPKISATKEIKL--HPQTVNEECVQKLETNASPYANKNIAIDS-------AMLDLRNCKVGSPV 1827

  Fly   902 ILSTET----------STSCALPTMERFAPKPSSTSTPLADRDLNRSKD--CTKNRQDAEDMSPI 954
            .::|.:          :.:|:....:....||.:..|. ..:.|:.|:|  |..:..|....||:
  Rat  1828 FITTHSQETVRMKEIFTDNCSKIVEQNRESKPDTCQTS-CHKALDNSEDFICPSSSGDVCINSPM 1891

  Fly   955 CMQPKKSRRL 964
            .:...:|.::
  Rat  1892 AIFYPQSEQI 1901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Brca2	NP_611925.2	None
Brca2	XP_038945468.1	BRCA2	985..1015	CDD:395509	7/31 (23%)
		BRCA2	1198..1228	CDD:395509	9/52 (17%)
		BRCA2	1406..1436	CDD:395509	9/31 (29%)
		BRCA2	1504..1534	CDD:395509	4/32 (13%)
		BRCA2	1639..1669	CDD:395509	6/36 (17%)
		BRCA2	1942..1970	CDD:395509
		BRCA-2_helical	2411..2597	CDD:401201
		BRCA-2_OB1	2600..2723	CDD:401152
		BRCA2DBD_OB2	2734..3012	CDD:239940
		BRCA-2_OB3	3012..3142	CDD:401153

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006415
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900