Protein Alignment Brca2 and brca2

DIOPT Version :10

• Sequence 1: NP_611925.2
• Gene: Brca2 / 37916
• FlyBaseID: FBgn0050169
• Length: 971
• Species: Drosophila melanogaster
• Sequence 2: XP_031753094.1
• Gene: brca2 / 100038818
• XenbaseID: XB-GENE-6453899
• Length: 3238
• Species: Xenopus tropicalis
• Alignment Length: 1068
• Identity: 234/1068 - (21%)
• Similarity: 376/1068 - (35%)
• Gaps: 309/1068 - (28%)

  Fly    24 ERGATVSAAANRSNIID-EMAKICEADRQTFA----IARRTRGHE--RLAVDNSDFVAVEDLILS 81
            |.|.::....:..:..| ||....|.|.:..|    ||:.|..:|  :|.:...|....:|..|.
 Frog   376 EEGESILVPLDEHHKCDHEMLMKPEQDYKMNAVNQKIAKETTPYEWSQLNICELDITQSQDSTLH 440

  Fly    82 YAEPTPEDQVEMIMSDFCSSPTYAEDEDEPSHESEPWFRFRNKRIRTYSRKRDPKSHKAVQNEKR 146
            .|....|| :.:..||.|:. |.||.::|.:                     :|.:...:.|:..
 Frog   441 AANLCCED-ITVNKSDTCNI-TEAEKQEEVN---------------------EPSTDNVLSNKVG 482

  Fly   147 RGSSGLSVQRDLNTSFTSMACDFDASSQKIHEVLLNLSQYFSATATASGPTPV---------PSQ 202
            :.|: |:| ..:|....:||   .:|:..:|.  |||||.....::....:.|         |::
 Frog   483 KEST-LNV-NCINADLNNMA---SSSNNSVHS--LNLSQCEKMDSSEISNSEVGCITKLTTHPAK 540

  Fly   203 IDLPTEARQDSGDECFNAELENLRDDLLQSGFTFEASFYENEHEQEGPGTMADTIYGD--SMQSV 265
            |   |.....|.|:|.....|.:         |...||...:.:.:...::...:.|.  |..|:
 Frog   541 I---TTGELSSVDDCAKKPQERV---------TISTSFSTLKKQSKFMYSVNTVLTGHIASNTSI 593

  Fly   266 PTTRLRLESGKRNVWSDADST-LKKADVEIAENKKLLMGQTQAKNVDIE-ENTNFILEGIPLSEW 328
            .|.|    |...::.||.... :|:...|...|.|......| |.|.:| ||.|   :||.|.:.
 Frog   594 ATRR----SLNSHLSSDEPKPHIKENQNEPESNAKYYSNGLQ-KPVFLEKENDN---KGISLCKT 650

  Fly   329 LTP-------MELPEISKDVIKHIPDKKLKLEPSSQKEQKSSKDSNASKVRGASKQSCDINTKNE 386
            ::.       ...|:..::   .:|:.|.:.:.:....:|....:|..    |.||   :.|
 Frog   651 ISDGQNTSEGARAPDYFEE---RVPETKDRCKATLSIREKVVATANCF----ARKQ---LET--- 702

  Fly   387 GTTILDQPNAAEQENLLNDGELLEEFLFNDWQPMQCSNGPSTSKNAIQGPKENI--------NSI 443
                 |.|..|..::        |...|:..|.:.||...|...|.:|...:.:        ::.
 Frog   703 -----DYPEDASAQH--------EALQFHAKQYVSCSMLNSNVSNDMQIKPQVLTQACDFRSSAE 754

  Fly   444 NLDDKEQPEKQTPNKSQTISSHQLNGIRKKSFKFIEVSEEMKIKGEEFVDKVVSGLYHFSHKCNL 508
            ||.:|.:.:.:. |:.|:.||   .||.||           ...||:.|.....|  .|.|.
 Frog   755 NLVEKTKNQLRR-NEDQSFSS---TGIGKK-----------PASGEKLVGDCNEG--SFLHV--- 799

  Fly   509 RTEEYSDNHSQV---MESTQCAEFKSAPSKPIEILDGK---ETYNAIAKVDVGEINGKFSPLNND 567
             .:|.|...:.|   .|:....:..|..::.:....||   |...|:.::.|.||..|
 Frog   800 -KQEISAAQALVGNGYETRDTPDVTSDHTRSVISNHGKSLWEEETALTELPVPEILSK------- 856

  Fly   568 TIAEPEFCGFRTASNKAIPISEKMKIKTAEFMAEFQ-----SKETIQQN-DYLVHQPNDKPTSVG 626
                 .|.||:|||||.|.||:|..:|..:...|.:     :|...::| :.|...|.|.|   |
 Frog   857 -----TFKGFKTASNKKIHISDKNIVKGCDLFKEIEFGIGDAKPCNEENKEPLKKTPFDVP---G 913

  Fly   627 LDTALKRSIESSEEMRSKASKLVVVDTTMREPHQPTLDPVCRDLNESQFFGFRTASNKAIEITE- 690
            .:|.||                                            ||:|||||.|.::|
 Frog   914 YETNLK--------------------------------------------GFKTASNKEINVSEN 934

  Fly   691 ---------------------AMEKRGAMFL--AQSKATD-----QLNGWQPSDFPDVLPTSPNN 727
                                 .|.|...:|:  |.|...|     .:.|..||:..|.:|....:
 Frog   935 KFAKGRLLFKDIEEESGQTTAIMAKDNELFIKPASSNKPDIFKSTCIKGMNPSENLDSMPPKKGD 999

  Fly   728 EIHSINVENNKAV------------NTKTV-------SETEFFGFRTASNKGIVISENTKIKVAQ 773
            ...|..::::..:            |.:|:       |||:|.||:|||||.|:|||:|..|...
 Frog  1000 VQQSAGLKHSDQIDVFGFDDPPAKGNVQTLGYFNMSASETDFKGFKTASNKDIIISESTLAKGKL 1064

  Fly   774 FMSEFQAADASTDSNQPTVISEESRNIDAKFVDEAAAEDSAN---KPTFCNVQ--SLKNTSDIEH 833
            ...:.          :.|..||..|.||.|  .:..|..::|   ..|.|..:  :.:||:|
 Frog  1065 IFEDI----------EDTRYSETGRTIDCK--AKGGALSTSNLVMHNTMCKNEPSTSENTND--- 1114

  Fly   834 FKHDFFVEHSAKEEHPLCSQPLVRTPRRSQEI-----H------SSLSQLAGKSPLDQATKKSVI 887
                 .....||.:.|:.....::.|...:..     |      |:.|..|..|.|.:..||.:.
 Frog  1115 -----KAPKRAKVQTPMAENSHLKEPSSDKNAMDAANHQMTLKASAYSPKAASSALPRYKKKPIS 1174

  Fly   888 ARRNLLSLKRKRKIILSTETSTSCALP---------TMERFAP----KPSSTSTPLADRDLNRS- 938
            ..:....|..........|.|...::.         |..|..|    |.:||......::||.|
 Frog  1175 TTKTSFQLNEHLTESQQAEISELSSILENADSQFDFTQFRKVPSVTEKQNSTEGGSESQNLNNSD 1239

  Fly   939 --KDCTKN------RQDAEDMSPICMQP 958
              ||...|      |..:|.|..|...|
 Frog  1240 VWKDVDFNDSFAAGRDHSEGMEAIPSSP 1267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Brca2	NP_611925.2	None
brca2	XP_031753094.1	BRCA2	857..885	CDD:459881	13/27 (48%)
		BRCA2	919..945	CDD:459881	10/69 (14%)
		BRCA2	1041..1068	CDD:459881	14/26 (54%)
		BRCA2	1448..1474	CDD:459881
		BRCA2	1534..1559	CDD:459881
		BRCA2	1726..1753	CDD:459881
		BRCA2	1859..1887	CDD:459881
		BRCA2	1936..1961	CDD:459881
		BRCA-2_helical	2309..2495	CDD:462700
		BRCA-2_OB1	2498..2625	CDD:462678
		BRCA2DBD_OB2	2634..2885	CDD:239940
		BRCA-2_OB3	2884..3021	CDD:462679