DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and HNRNPDL

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_112740.1	Gene:	HNRNPDL / 9987	HGNCID:	5037	Length:	420	Species:	Homo sapiens

Alignment Length:	318	Identity:	78/318 - (24%)
Similarity:	128/318 - (40%)	Gaps:	65/318 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PANYHQQQPALNHHTLAAAHHQQQLHHHAAAAGHLSHVGGG----------HAASNHL-----AA 61
            |::..|.......|..|     ||....|..|.    :.||          |..|:.:     ||
Human    47 PSSARQGARRAQRHVTA-----QQPSRLAGGAA----IKGGRRRRPDLFRRHFKSSSIQRSAAAA 102

  Fly    62 AAVLGRHGHNSLGSGHTSTSSHS-ANVGVGVGGGALASGSTGGSGGNSSPDSGKIYIKNLERSID 125
            ||......|....|..|....:. :|:      ...|.||...:..|.. |.||::|..|.....
Human   103 AATRTARQHPPADSSVTMEDMNEYSNI------EEFAEGSKINASKNQQ-DDGKMFIGGLSWDTS 160

  Fly   126 NKAVYDTFSVFGNILNCNVAKDE-DGNSRGYGFVHFDSEEAARAAIE----KVNGMLCNNQKVHV 185
            .|.:.:..|.||.:::|.:..|. .|.|||:|||.|....:....:|    |::|.|.:
Human   161 KKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLID------ 219

  Fly   186 VKFIPRRDREQEKATHFKNLYVKNLSEEFTEQHLREMFEPYGRITSHKLMLDEEGRSRR-FGFVA 249
                |:|.:..:.....|.::|..||.:.:|:.::|.|..:|.|.:.:|.:|.:...|| |.|:.
Human   220 ----PKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFIT 280

  Fly   250 Y--ENPQSALAAVIGLHGK--QLGDNKFLYVARALSKAERQQEINRKLEERKRQKAGQ 303
            |  |.|...|     |..:  |:|..|      ...|..:.:|:.|  :::::||.|:
Human   281 YTDEEPVKKL-----LESRYHQIGSGK------CEIKVAQPKEVYR--QQQQQQKGGR 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	20/74 (27%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	23/84 (27%)
HNRNPDL	NP_112740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..120		6/23 (26%)
		RRM1_hnRPDL	149..224	CDD:410152	23/84 (27%)
		RRM2_hnRPDL	234..308	CDD:409998	23/84 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..348		4/15 (27%)
		Necessary for interaction with TNPO1. /evidence=ECO:0000269\|PubMed:9524220	342..420
		Necessary for its nuclear import and export	396..420
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..420
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870