DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and SART3

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	XP_005269298.1	Gene:	SART3 / 9733	HGNCID:	16860	Length:	981	Species:	Homo sapiens

Alignment Length:	204	Identity:	49/204 - (24%)
Similarity:	90/204 - (44%)	Gaps:	23/204 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 NSSPDSGKIYIKNLERSI---DNKAVYDTFSVFGNILNCNVAKDEDGNSRGYGFVHFDSEEAARA 168
            :||.||..:::.||..|:   |.| :...|...|.::.........|:.|||.:|.|..|::|..
Human   716 DSSKDSITVFVSNLPYSMQEPDTK-LRPLFEACGEVVQIRPIFSNRGDFRGYCYVEFKEEKSALQ 779

  Fly   169 AIE----KVNGMLCNNQKVHVVKFIPRRDREQEKATHFK------NLYVKNLSEEFTEQHLREMF 223
            |:|    .|.|     :.:.|...:.:......|...:.      .|::..|....|::.|.|:.
Human   780 ALEMDRKSVEG-----RPMFVSPCVDKSKNPDFKVFRYSTSLEKHKLFISGLPFSCTKEELEEIC 839

  Fly   224 EPYGRITSHKLMLDEEGRSRRFGFVAYENPQSALAAVIGLHGKQLGDNKFLYVARALSKAERQQE 288
            :.:|.:...:|:.:..|:.:...:|.|||...|..||:.:.|..:.:|   .:..|:|... |::
Human   840 KAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIKEN---IIKVAISNPP-QRK 900

  Fly   289 INRKLEERK 297
            :..|.|.||
Human   901 VPEKPETRK 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	19/76 (25%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	18/85 (21%)
SART3	XP_005269298.1	RNA14	100..>478	CDD:227438
		NRDE-2	351..>504	CDD:285605
		RRM	654..876	CDD:223796	38/165 (23%)
		RRM1_SART3	723..796	CDD:240837	19/78 (24%)
		RRM2_SART3	817..897	CDD:240838	19/82 (23%)
		LSM_int_assoc	895..951	CDD:293211	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.861654	Normalized mean entropy	S4474
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860