DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and TIA1

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_071505.2	Gene:	TIA1 / 7072	HGNCID:	11802	Length:	386	Species:	Homo sapiens

Alignment Length:	167	Identity:	49/167 - (29%)
Similarity:	80/167 - (47%)	Gaps:	14/167 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 IYIKNLERSIDNKAVYDTFSVFGNILNCNVAKDEDGNSRGYGFVHFDSEEAARAAIEKVNGMLCN 179
            :|:.||.|.:....:...||..|...||.:..|..||. .|.||.|.....|.||:..:||....
Human     9 LYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGND-PYCFVEFHEHRHAAAALAAMNGRKIM 72

  Fly   180 NQKVHV----VKFIPRRDRE-------QEKATHFKNLYVKNLSEEFTEQHLREMFEPYGRITSHK 233
            .::|.|    .....::|..       |....|| :::|.:||.|.|.:.::..|.|:|||:..:
Human    73 GKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHF-HVFVGDLSPEITTEDIKAAFAPFGRISDAR 136

  Fly   234 LMLD-EEGRSRRFGFVAYENPQSALAAVIGLHGKQLG 269
            ::.| ..|:|:.:|||::.|...|..|:..:.|:.||
Human   137 VVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLG 173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	22/69 (32%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	23/69 (33%)
TIA1	NP_071505.2	RRM1_TIA1	8..81	CDD:410027	23/72 (32%)
		RRM2_TIA1	104..181	CDD:410030	24/71 (34%)
		RRM3_TIAR	214..286	CDD:241064
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910