DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and CELF5

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_068757.2	Gene:	CELF5 / 60680	HGNCID:	14058	Length:	485	Species:	Homo sapiens

Alignment Length:	223	Identity:	54/223 - (24%)
Similarity:	94/223 - (42%)	Gaps:	34/223 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 GSTGGSGGNSSP------DSGKIYIKNLERSIDNKAVYDTFSVFGNILNCNVAKDE-DGNSRGYG 156
            ||:|.......|      |:.|:::..:.|.:|.|.:...|..||.|....|.||. .|..:|..
Human    25 GSSGPEPPGGQPDGMKDLDAIKLFVGQIPRHLDEKDLKPLFEQFGRIYELTVLKDPYTGMHKGCA 89

  Fly   157 FVHFDSEEAARAAIEKVNGMLCNNQKVHVVKFIPRRDR--------EQEKATHFKNLYVKNLSEE 213
            |:.:.:.::|..|          ...:|..|.:|...|        .:.:....:.|:|..|:::
Human    90 FLTYCARDSAIKA----------QTALHEQKTLPGMARPIQVKPADSESRGGRDRKLFVGMLNKQ 144

  Fly   214 FTEQHLREMFEPYGRITSHKLMLDEEGRSRRFGFVAYENPQSALAAVIGLHGKQL--GDNKFLYV 276
            .:|:.:..:|:|:|.|....::...:|.|:...||.:.:...|.||:..|||.|.  |.:..|.|
Human   145 QSEEDVLRLFQPFGVIDECTVLRGPDGSSKGCAFVKFSSHTEAQAAIHALHGSQTMPGASSSLVV 209

  Fly   277 ARALSKAERQQEINRKLEERKRQKAGQI 304
            ..|.:..||..       .|.:|..||:
Human   210 KFADTDKERTL-------RRMQQMVGQL 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	15/70 (21%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	23/81 (28%)
CELF5	NP_068757.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		4/14 (29%)
		RRM1_CELF3_4_5_6	40..126	CDD:410041	21/95 (22%)
		half-pint	46..>372	CDD:130706	49/202 (24%)
		RRM2_CELF3_4_5_6	133..213	CDD:410043	22/79 (28%)
		RRM3_CELF3_4_5_6	396..474	CDD:241083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910