DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and CELF4

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_001340669.1	Gene:	CELF4 / 56853	HGNCID:	14015	Length:	545	Species:	Homo sapiens

Alignment Length:	262	Identity:	68/262 - (25%)
Similarity:	110/262 - (41%)	Gaps:	49/262 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SLGSGHTSTSSHSANVGVGVGGGALASGSTGG---SGGNSSP------DSGKIYIKNLERSIDNK 127
            :|.:|....:|.|.|   |:|....::|...|   |.||.|.      |:.|::|..:.|::|.|
Human     7 TLANGQADNASLSTN---GLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQIPRNLDEK 68

  Fly   128 AVYDTFSVFGNILNCNVAKDE-DGNSRGYGFVHFDSEEAARAAIEKVNGMLCNNQKVHVVKFIPR 191
            .:...|..||.|....|.||. .|..:|..|:.:...|:|..|          ...:|..|.:|.
Human    69 DLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKA----------QSALHEQKTLPG 123

  Fly   192 RDRE-----------------QEKATHFKNLYVKNLSEEFTEQHLREMFEPYGRITSHKLMLDEE 239
            .:|.                 ::..:..:.|:|..|:::.:|..:|.:||.:|.|....::...:
Human   124 MNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLNKQQSEDDVRRLFEAFGNIEECTILRGPD 188

  Fly   240 GRSRRFGFVAYENPQSALAAVIGLHGKQL--GDNKFLYVARALSKAERQQEINRKLEERKRQKAG 302
            |.|:...||.|.:...|.||:..|||.|.  |.:..|.|..|.:..||..       .|.:|.||
Human   189 GNSKGCAFVKYSSHAEAQAAINALHGSQTMPGASSSLVVKFADTDKERTM-------RRMQQMAG 246

  Fly   303 QI 304
            |:
Human   247 QM 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	17/70 (24%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	25/81 (31%)
CELF4	NP_001340669.1	Sufficient for RNA-binding and MSE-dependent splicing activity	1..298		68/262 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..39		6/23 (26%)
		RRM1_CELF3_4_5_6	49..135	CDD:241076	23/95 (24%)
		PABP-1234	<56..378	CDD:130689	53/210 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..149		2/27 (7%)
		RRM2_CELF3_4_5_6	151..231	CDD:241079	24/79 (30%)
		Necessary for TNNT2 exon 5 inclusion	239..258		5/10 (50%)
		RRM_SF	417..>445	CDD:388407
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910