DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and Sart3

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_001343550.1	Gene:	Sart3 / 53890	MGIID:	1858230	Length:	980	Species:	Mus musculus

Alignment Length:	250	Identity:	55/250 - (22%)
Similarity:	101/250 - (40%)	Gaps:	25/250 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RHGHNSLGSGHTSTSSHSANVG-----VGVG-------GGALASGSTGGSGGNSSPDSGKIYIKN 119
            |...|||.||..|.......:.     :.||       ..|...........:||.||..:::.|
Mouse   664 RRTENSLASGEASAMKEETELSGKCLTIDVGPPSKQKEKAASLKRDMPKVAHDSSKDSVTVFVSN 728

  Fly   120 LERSIDNKAV--YDTFSVFGNILNCNVAKDEDGNSRGYGFVHFDSEEAARAAIEKVNGMLCNNQK 182
            |..||:...|  ...|.|.|.::.........|:.|||.:|.|..|::|:.|:| ::..:...:.
Mouse   729 LPYSIEEPEVKLRPLFEVCGEVVQIRPIFSNRGDFRGYCYVEFGEEKSAQQALE-LDRKIVEGRP 792

  Fly   183 VHVVKFIPRRDREQEKATHFK------NLYVKNLSEEFTEQHLREMFEPYGRITSHKLMLDEEGR 241
            :.|...:.:......|...:.      .|::..|....|::.|.::.:.:|.:...:|:.:..|:
Mouse   793 MFVSPCVDKSKNPDFKVFRYSTTLEKHKLFISGLPFSCTKEELEDICKAHGTVKDLRLVTNRAGK 857

  Fly   242 SRRFGFVAYENPQSALAAVIGLHGKQLGDNKFLYVARALSKAERQQEINRKLEER 296
            .:...:|.|||...|..||:.:.|..:.:|    |.:.......|:::..|.|.|
Mouse   858 PKGLAYVEYENESQASQAVMKMDGMTIREN----VIKVAISNPPQRKVPEKPEVR 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	18/71 (25%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	17/85 (20%)
Sart3	NP_001343550.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92
		Suf	101..>479	CDD:331814
		HAT 5. /evidence=ECO:0000255	343..375
		HAT 6. /evidence=ECO:0000255	378..410
		HAT 7. /evidence=ECO:0000255	413..449
		HAT 8. /evidence=ECO:0000255	459..492
		Required for interaction with USP4. /evidence=ECO:0000250\|UniProtKB:Q15020	506..539
		Necessary and sufficient for U6 snRNA binding. /evidence=ECO:0000250\|UniProtKB:Q15020	556..970		54/249 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..714		10/49 (20%)
		Required for nuclear localization. /evidence=ECO:0000250\|UniProtKB:Q15020	619..688		7/23 (30%)
		RRM1_SART3	723..796	CDD:240837	18/73 (25%)
		RRM2_SART3	817..897	CDD:240838	17/83 (20%)
		LSM_int_assoc	895..953	CDD:318746	3/13 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	898..980		3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.861654	Normalized mean entropy	S4474
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950