DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and NONO

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_001138880.1	Gene:	NONO / 4841	HGNCID:	7871	Length:	471	Species:	Homo sapiens

Alignment Length:	232	Identity:	51/232 - (21%)
Similarity:	96/232 - (41%)	Gaps:	50/232 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 SGKIYIKNLERSIDNKAVYDTFSVFGNILNCNVAKDEDGNSRGYGFVHFDSEEAARAAIEKVN-- 174
            |..:.::||.:.:.|:.:.:.|||||.:....|..|:.|...|.|.|.|..:.|||.|:::.:
Human   147 SASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGKGIVEFSGKPAARKALDRCSEG 211

  Fly   175 ---------------------------GMLCNNQKVHVVKFIPRR-----DREQEKATHFKNLY- 206
                                       .::..||:.|..:..|.|     ..|.|.|..:|.|.
Human   212 SFLLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQPPRFAQPGSFEYEYAMRWKALIE 276

  Fly   207 VKNLSEEFTEQHLREM-----FEPYGRITSHKLMLDEEGRSRRFGFVAYENPQSALAAVIGLHGK 266
            ::...::..:::::|.     .|.......|::||..:...||         |..|..:..||.:
Human   277 MEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMRR---------QEELRRMEELHNQ 332

  Fly   267 QLGDNKFLYVARALSKAERQQEINRKLEE-RKRQKAG 302
            ::...|.|.:.:...:..|::|:.|:.|| .:||:.|
Human   333 EVQKRKQLELRQEEERRRREEEMRRQQEEMMRRQQEG 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	21/98 (21%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	15/85 (18%)
NONO	NP_001138880.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		DBHS	54..373		51/232 (22%)
		RRM1_p54nrb	73..143	CDD:410001
		RRM_SF	149..228	CDD:418427	19/78 (24%)
		NOPS_p54nrb_PSF_PSPC1	219..311	CDD:240581	13/91 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910