DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and spen

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_722615.1	Gene:	spen / 44205	FlyBaseID:	FBgn0016977	Length:	5560	Species:	Drosophila melanogaster

Alignment Length:	306	Identity:	69/306 - (22%)
Similarity:	118/306 - (38%)	Gaps:	69/306 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 HTLAAAHHQQQLHHHAAAAGHLSH------VGGGHA------ASNHLAAAAVLGRHGHNSLGSGH 77
            |.:...|:   ||..:..:...||      ....|:      :|:|..|::.:...|:.::..|.
  Fly   428 HPIRTRHN---LHGRSTTSSSRSHSRSPSSYSSSHSSSSSSHSSSHSHASSPVQSSGNCAMAEGR 489

  Fly    78 ----------TSTSSHSANVGV-----GVGGGALASGSTGGSGGNS------------SPDSG-- 113
                      ||.||:.:...|     |||||..:|.|:..|..:|            |.|:.
  Fly   490 SSRTVNSVTVTSNSSNPSGTAVTVSSAGVGGGCGSSSSSSSSSSSSGSSCLTANPVVHSEDNRPL 554

  Fly   114 KIYIKNL-ERSIDNK---AVYDTFSVFGNILNCNVAKDEDGNSRGYGFVHFDSEEAARAAIE--- 171
            .|.::|| .||.|..   .::..:...|.:....|...   ||..|..|.|...:....|:|
  Fly   555 AIRVRNLPARSSDTSLKDGLFHEYKKHGKVTWVKVVGQ---NSERYALVCFKKPDDVEKALEVSH 616

  Fly   172 -------KVNGMLCNNQKVHVVKFIP---RRDREQEKATHFKNLYVKNLSEEFTEQHLREMFEPY 226
                   |:.........|...:|.|   ..|....|:|  :.|::.||.::.|...||..||.:
  Fly   617 DKHFFGCKIEVEPYQGYDVEDNEFRPYEAELDEYHPKST--RTLFIGNLEKDITAGELRSHFEAF 679

  Fly   227 GRITSHKLMLDEEGRSRRFGFVAYENPQSALAAVIGLHGKQLGDNK 272
            |.|.  ::.:.::|.: .:.|..|.:..|.:.|:..:.|:.||.|:
  Fly   680 GEII--EIDIKKQGLN-AYAFCQYSDIVSVVKAMRKMDGEHLGSNR 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	17/83 (20%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	19/71 (27%)
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795	16/75 (21%)
		RRM3_SHARP	654..726	CDD:240796	20/74 (27%)
		RRM4_SHARP	727..803	CDD:240797
		RILP-like	1997..>2055	CDD:304877
		SPOC	5404..5527	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910