DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and PABPC1

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_002559.2	Gene:	PABPC1 / 26986	HGNCID:	8554	Length:	636	Species:	Homo sapiens

Alignment Length:	191	Identity:	97/191 - (50%)
Similarity:	138/191 - (72%)	Gaps:	5/191 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 GKIYIKNLERSIDNKAVYDTFSVFGNILNCNVAKDEDGNSRGYGFVHFDSEEAARAAIEKVNGML 177
            |.|:||||::||||||:|||||.|||||:|.|..||:| |:|||||||:::|||..||||:||||
Human    99 GNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENG-SKGYGFVHFETQEAAERAIEKMNGML 162

  Fly   178 CNNQKVHVVKFIPRRDREQE---KATHFKNLYVKNLSEEFTEQHLREMFEPYGRITSHKLMLDEE 239
            .|::||.|.:|..|::||.|   :|..|.|:|:||..|:..::.|:::|..:|...|.|:|.||.
Human   163 LNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDES 227

  Fly   240 GRSRRFGFVAYENPQSALAAVIGLHGKQLGDNKFLYVARALSKAERQQEINRKLEERKRQK 300
            |:|:.||||::|..:.|..||..::||:| :.|.:||.||..|.|||.|:.||.|:.|:.:
Human   228 GKSKGFGFVSFERHEDAQKAVDEMNGKEL-NGKQIYVGRAQKKVERQTELKRKFEQMKQDR 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	48/69 (70%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	32/79 (41%)
PABPC1	NP_002559.2	PABP-1234	11..615	CDD:130689	97/191 (51%)
		CSDE1-binding	166..289		50/123 (41%)
		(Microbial infection) Binding to HRSV M2-1 protein. /evidence=ECO:0000269\|PubMed:31649314	541..636
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027234at2759
OrthoFinder	1	1.000	-	-		FOG0000294
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100425
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920