DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and RBFOX2

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	XP_006724248.1	Gene:	RBFOX2 / 23543	HGNCID:	9906	Length:	465	Species:	Homo sapiens

Alignment Length:	155	Identity:	42/155 - (27%)
Similarity:	68/155 - (43%)	Gaps:	15/155 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 AAVLGRHGHNSLGS--GHTSTSSHSANVGVG----VGGGALASG------STGGSGGNSSPDSGK 114
            |...|.|.....||  .|...||:|.:...|    ..|||...|      |:..|...|:|.  :
Human   121 AGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPK--R 183

  Fly   115 IYIKNLERSIDNKAVYDTFSVFGNILNCNVAKDEDGNSRGYGFVHFDSEEAARAAIEKVNGMLCN 179
            :::.|:.....:..:...|..||.||:..:..:|.| |:|:|||.|::...|..|.||::|.:..
Human   184 LHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERG-SKGFGFVTFENSADADRAREKLHGTVVE 247

  Fly   180 NQKVHVVKFIPRRDREQEKATHFKN 204
            .:|:.|.....|....::..|.:.|
Human   248 GRKIEVNNATARVMTNKKMVTPYAN 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	20/69 (29%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	1/3 (33%)
RBFOX2	XP_006724248.1	RRM	<165..>266	CDD:223796	26/103 (25%)
		RRM_FOX1_like	182..257	CDD:240853	21/77 (27%)
		Fox-1_C	326..>383	CDD:289199
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910