DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and U2af2

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_001192160.1	Gene:	U2af2 / 22185	MGIID:	98886	Length:	475	Species:	Mus musculus

Alignment Length:	209	Identity:	43/209 - (20%)
Similarity:	83/209 - (39%)	Gaps:	48/209 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 GGNSSPDSGKIYIKNLERSIDNKAVYDTFSVF----------GN-ILNCNVAKDEDGNSRGYGFV 158
            |...:..:.::|:.|:...|..:|:.|.|:..          || :|...:.:|     :.:.|:
Mouse   141 GSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQD-----KNFAFL 200

  Fly   159 HFDSEEAARAAIEKVNGMLCNNQKVHVVKFIPRRDREQE----------------------KATH 201
            .|.|.:....|: ..:|::...|.:.:     ||..:.:                      .:.|
Mouse   201 EFRSVDETTQAM-AFDGIIFQGQSLKI-----RRPHDYQPLPGMSENPSVYVPGVVSTVVPDSAH 259

  Fly   202 FKNLYVKNLSEEFTEQHLREMFEPYGRITSHKLMLDE-EGRSRRFGFVAYENPQSALAAVIGLHG 265
              .|::..|.....:..::|:...:|.:.:..|:.|. .|.|:.:.|..|.:......|:.||:|
Mouse   260 --KLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNG 322

  Fly   266 KQLGDNKFLYVARA 279
            .||||.|.| |.||
Mouse   323 MQLGDKKLL-VQRA 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	16/80 (20%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	23/79 (29%)
U2af2	NP_001192160.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90
		Required for interaction with PRPF19. /evidence=ECO:0000250\|UniProtKB:P26368	2..93
		Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner. /evidence=ECO:0000250\|UniProtKB:P26368	17..47
		U2AF_lg	63..474	CDD:273727	43/209 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910