DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and Celf4

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_001349204.1	Gene:	Celf4 / 108013	MGIID:	1932407	Length:	554	Species:	Mus musculus

Alignment Length:	262	Identity:	69/262 - (26%)
Similarity:	111/262 - (42%)	Gaps:	50/262 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SLGSGHTSTSSHSANVGVGVGGGALASGSTGG---SGGNSSP------DSGKIYIKNLERSIDNK 127
            :|.:|....:|.|.|   |:|....::|...|   |.||.|.      |:.|::|..:.|::|.|
Mouse     7 TLANGQADNASLSTN---GLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQIPRNLDEK 68

  Fly   128 AVYDTFSVFGNILNCNVAKDE-DGNSRGYGFVHFDSEEAARAAIEKVNGMLCNNQKVHVVKFIPR 191
            .:...|..||.|....|.||. .|..:|..|:.:...|:|..|          ...:|..|.:|.
Mouse    69 DLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKA----------QSALHEQKTLPG 123

  Fly   192 RDRE-----------------QEKATHFKNLYVKNLSEEFTEQHLREMFEPYGRITSHKLMLDEE 239
            .:|.                 ::..:| :.|:|..|:::.:|..:|.:||.:|.|....::...:
Mouse   124 MNRPIQVKPADSESRGGSSCLRQPPSH-RKLFVGMLNKQQSEDDVRRLFEAFGNIEECTILRGPD 187

  Fly   240 GRSRRFGFVAYENPQSALAAVIGLHGKQL--GDNKFLYVARALSKAERQQEINRKLEERKRQKAG 302
            |.|:...||.|.:...|.||:..|||.|.  |.:..|.|..|.:..||..       .|.:|.||
Mouse   188 GNSKGCAFVKYSSHAEAQAAINALHGSQTMPGASSSLVVKFADTDKERTM-------RRMQQMAG 245

  Fly   303 QI 304
            |:
Mouse   246 QM 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	17/70 (24%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	25/81 (31%)
Celf4	NP_001349204.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..39		6/23 (26%)
		RRM1_CELF3_4_5_6	49..135	CDD:241076	23/95 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..149		2/27 (7%)
		RRM2_CELF3_4_5_6	150..230	CDD:241079	25/80 (31%)
		Necessary for TNNT2 exon 5 inclusion. /evidence=ECO:0000250	238..257		5/10 (50%)
		RRM_SF	415..>463	CDD:388407
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910