DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and CELF2

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	XP_024303540.1	Gene:	CELF2 / 10659	HGNCID:	2550	Length:	549	Species:	Homo sapiens

Alignment Length:	242	Identity:	57/242 - (23%)
Similarity:	109/242 - (45%)	Gaps:	33/242 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 HSANVGVGVGGGALASGSTGGSGG------NSSPDSGKIYIKNLERSIDNKAVYDTFSVFGNILN 141
            :|......:.|...::|:.....|      ...||:.|:::..:.||...|.:.:.|..:|.:..
Human    35 YSQETATELAGSLPSNGTANKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQ 99

  Fly   142 CNVAKDEDGN---SRGYGFVHFDSEEAARAAIEKVNGMLCNNQKVHVVKFIP---------RRDR 194
            .||.:|...|   |:|..||.|.:.   :||:|..|.:       |.:|.:|         ..|.
Human   100 INVLRDRSQNPPQSKGCCFVTFYTR---KAALEAQNAL-------HNIKTLPGMHHPIQMKPADS 154

  Fly   195 EQEKATHFKNLYVKNLSEEFTEQHLREMFEPYGRITSHKLMLDEEGRSRRFGFVAYENPQSALAA 259
            |:..|...:.|::..:|::..|..:|.||.|:|:|...:::...:|.||...||.:.....|..|
Human   155 EKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNA 219

  Fly   260 VIGLHGKQL--GDNKFLYVARALSKAERQQEINRKLEERKRQKAGQI 304
            :..:|..|.  |.:..:.|..|.::.:::|   |:|:::..|:..|:
Human   220 IKAMHQSQTMEGCSSPIVVKFADTQKDKEQ---RRLQQQLAQQMQQL 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	18/72 (25%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	21/81 (26%)
CELF2	XP_024303540.1	RRM1_CELF1_2_Bruno	70..153	CDD:241075	22/92 (24%)
		RRM2_CELF1_2	162..242	CDD:241078	20/79 (25%)
		RRM3_CELF1_2	457..548	CDD:241082
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910