DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4612 and CELF1

DIOPT Version :9

Sequence 1:	NP_001246493.1	Gene:	CG4612 / 37914	FlyBaseID:	FBgn0035016	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_001317201.1	Gene:	CELF1 / 10658	HGNCID:	2549	Length:	514	Species:	Homo sapiens

Alignment Length:	272	Identity:	71/272 - (26%)
Similarity:	115/272 - (42%)	Gaps:	58/272 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QQPAL--NHHTLAAAH-----HQQQLHHHAAAAGHLSHV----GGGHAASNHLAAAAVLGRHGHN 71
            ||.|.  |.:||::.|     :..||.:.||.|...|..    .|.:|.:...:..:||    .:
Human   263 QQTASSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAAQNTPSGTNALTTSSSPLSVL----TS 323

  Fly    72 SLGSGHTSTSSHSANVGVGVGGGALASGSTGGSGGNSSPDSGKIYIKNLERSIDNKAVYDTFSVF 136
            |.||..:|:||:|.|....:|.....:|:|.|....|                           .
Human   324 SAGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGS---------------------------L 361

  Fly   137 GNILNCNVAKDEDGNSRGYGF-------VHFDSEEAARAAIEKV-NGMLCNNQKVHVVKFIPRRD 193
            ..:...|......|.|.|.|.       .:...::.|.||:..: |..|...|.:...
Human   362 AGMAALNGGLGSSGLSNGTGSTMEALTQAYSGIQQYAAAALPTLYNQNLLTQQSIGAA------- 419

  Fly   194 REQEKATHFKNLYVKNLSEEFTEQHLREMFEPYGRITSHKLMLDEE-GRSRRFGFVAYENPQSAL 257
            ..|::.....||::.:|.:||.:|.|.:||.|:|.:.|.|:.:|:: ..|:.||||:|:||.||.
Human   420 GSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQ 484

  Fly   258 AAVIGLHGKQLG 269
            ||:..::|.|:|
Human   485 AAIQSMNGFQIG 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4612	NP_001246493.1	RRM2_I_PABPs	115..185	CDD:240825	11/77 (14%)
CG4612	NP_001246493.1	RRM3_I_PABPs	202..282	CDD:240826	29/69 (42%)
CELF1	NP_001317201.1	RRM1_CELF1_2_Bruno	42..125	CDD:410040
		RRM2_CELF1_2	134..214	CDD:410042
		RRM3_CELF1_2	422..513	CDD:241082	30/75 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910