DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4612 and SYNCRIP

DIOPT Version :9

Sequence 1:NP_001246493.1 Gene:CG4612 / 37914 FlyBaseID:FBgn0035016 Length:307 Species:Drosophila melanogaster
Sequence 2:NP_006363.4 Gene:SYNCRIP / 10492 HGNCID:16918 Length:623 Species:Homo sapiens


Alignment Length:202 Identity:44/202 - (21%)
Similarity:96/202 - (47%) Gaps:15/202 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   112 SGKIYIKNLERSIDNKAVYDTFSVFGNILNCNV---AKDEDGNSRGYGFVHF-DSEEAARAAIEK 172
            :.::::.::.:|...:.:.:.||.....|...:   ..|:...:||:.|:.: |.:.||:|....
Human   242 NNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRL 306

  Fly   173 VNGMLCNNQKVHVVKFI-PRRDREQEKATHFKNLYVKNLSEEFTEQHLREMFEPYGRITSHKLML 236
            ::|.:.....|..|::. |..|.:.|.....|.|:|:||:...||:.|.:.|..:|::...|.:.
Human   307 MSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLK 371

  Fly   237 DEEGRSRRFGFVAYENPQSALAAVIGLHGKQL-GDNKFLYVARALSKAERQQEINRKLEERKRQK 300
            |       :.|:.::....|:.|:..::||.| |:|..:..|:...:..::::..|  :..|.|.
Human   372 D-------YAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQR--QAAKNQM 427

  Fly   301 AGQIFYY 307
            ....:||
Human   428 YDDYYYY 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4612NP_001246493.1 RRM2_I_PABPs 115..185 CDD:240825 14/73 (19%)
RRM3_I_PABPs 202..282 CDD:240826 21/80 (26%)
SYNCRIPNP_006363.4 NURR_hnRNPQ 23..107 CDD:410954
hnRNP-R-Q 103..615 CDD:273732 44/202 (22%)
Interaction with APOBEC1 400..561 7/37 (19%)
8 X 3 AA repeats of R-G-G 448..559
3 X 4 AA repeats of Y-Y-G-Y 460..488
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 497..623
Interaction with SMN. /evidence=ECO:0000269|PubMed:11574476 518..549
Bipartite nuclear localization signal. /evidence=ECO:0000255 564..578
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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