DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4612 and HNRNPR

DIOPT Version :9

Sequence 1:NP_001246493.1 Gene:CG4612 / 37914 FlyBaseID:FBgn0035016 Length:307 Species:Drosophila melanogaster
Sequence 2:NP_001095868.1 Gene:HNRNPR / 10236 HGNCID:5047 Length:636 Species:Homo sapiens


Alignment Length:307 Identity:54/307 - (17%)
Similarity:109/307 - (35%) Gaps:120/307 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   106 GNSSPDS----------GKIYIKNLERSIDNKAVYDTFSVFGNILNCNVAKDE-DGNSRGYGFVH 159
            |...|||          .::::..:.|.:....:...|...|.|.:..:..|. .|.:|||.|:.
Human   148 GGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFIT 212

  Fly   160 FDSEEAARAAIEKVNGMLCNNQKV----HV------------VKFIPRR---------------- 192
            |..:|||:.|::     ||::.::    |:            |..||:.                
Human   213 FCGKEAAQEAVK-----LCDSYEIRPGKHLGVCISVANNRLFVGSIPKNKTKENILEEFSKVTGL 272

  Fly   193 --------------DREQEKATHF----------------------------------------- 202
                          |:::.:...|                                         
Human   273 TEGLVDVILYHQPDDKKKNRGFCFLEYEDHKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDP 337

  Fly   203 ------KNLYVKNLSEEFTEQHLREMFEPYGRITSHKLMLDEEGRSRRFGFVAYENPQSALAAVI 261
                  |.|:|:||:...||:.|.:.|..:|::...|.:.|       :.||.:|:..:|:.|:.
Human   338 EVMAKVKVLFVRNLATTVTEEILEKSFSEFGKLERVKKLKD-------YAFVHFEDRGAAVKAMD 395

  Fly   262 GLHGKQL-GDNKFLYVARALSKAERQQEINRKLEERKRQKAGQIFYY 307
            .::||:: |:...:.:|:...|..::::..|   :..|..|.:.:||
Human   396 EMNGKEIEGEEIEIVLAKPPDKKRKERQAAR---QASRSTAYEDYYY 439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4612NP_001246493.1 RRM2_I_PABPs 115..185 CDD:240825 17/74 (23%)
RRM3_I_PABPs 202..282 CDD:240826 22/127 (17%)
HNRNPRNP_001095868.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
NURR_hnRNPR 27..110 CDD:410955
hnRNP-R-Q 106..631 CDD:273732 54/307 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..459 6/28 (21%)
Nuclear localization signal. /evidence=ECO:0000255 415..421 1/5 (20%)
RNA-binding RGG-box 450..570
3 X 11 AA approximate repeats of D-D-Y-Y-G-Y-D-Y-H-D-Y 465..500
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 504..636
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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