Protein Alignment Letm1 and LETM2

DIOPT Version :10

• Sequence 1: NP_611922.1
• Gene: Letm1 / 37912
• FlyBaseID: FBgn0284252
• Length: 1013
• Species: Drosophila melanogaster
• Sequence 2: NP_176732.2
• Gene: LETM2 / 842865
• AraportID: AT1G65540
• Length: 736
• Species: Arabidopsis thaliana
• Alignment Length: 718
• Identity: 232/718 - (32%)
• Similarity: 364/718 - (50%)
• Gaps: 90/718 - (12%)

  Fly    49 PRRSASTSVLELSRSLGTYRRFQPHANYGYDYSGYGFRHLHTSRTLLETSSSKIDATVKKLKNQQ 113
            |..|....:|||...|| ||..              |:.:::|  |...:....|...:|:.:|.
plant    66 PSFSNGVGILELPYPLG-YRLV--------------FQSMYSS--LATANKPDHDKKGEKVTSQT 113

  Fly   114 KEKVEEIMKEVANGQAAAVRASSAATATASSEKGQNASA------TAGSTSATASTTSLAKTADK 172
            ||...|...|...|.:.| :|.:.|.....|:|...:..      ..|...|..:..|:::   :
plant   114 KEASPEECDEAVEGLSLA-KAKAKAMKLEESQKSDISIMQRVRLFLLGIGPALRAIASMSR---E 174

  Fly   173 SVAKPKKPLRTRIWDELVHYYHGFRLLFIDVAICSKLLWRVLNGKTLTRRENKQLQRTTSDLFRL 237
            ..||..:..:......|.||:.|.:||:.||.|..:||.::.|||.|:|||.:||.|||:|:|||
plant   175 DWAKKLRHWKDEFKSTLQHYWLGTKLLWADVRISVRLLVKLANGKGLSRRERQQLTRTTADIFRL 239

  Fly   238 IPFSVFIIVPFMELLLPLFIKFFPGMLPSTFQTSTDRQEKLRQSLSVRLEVAKFLQQTLDQMPVQ 302
            :|.:|||||||||.|||:|:|.||.|||||||.....:|.|::.|:.|:|.|||||.|:.:|..:
plant   240 VPVAVFIIVPFMEFLLPVFLKLFPNMLPSTFQDKMKEEEALKRRLNARMEYAKFLQDTVKEMAKE 304

  Fly   303 HKEHSSEE----AKQFEAFFTKIRNPTEPVSNDEIIKFAKRFDDEITLDSLSREQLAALCRVLEL 363
            .:...|.|    |:..:.|.||:|... .||||||:.|||.|:||:|||:::|.:|..:|:.:.:
plant   305 VQTSRSGEIKKTAEDLDGFMTKVRRGV-GVSNDEILGFAKLFNDELTLDNINRSRLVNMCKYMGI 368

  Fly   364 NTIGTTTLLRFQLRLKLRSLATDDRVIAREGVDSLDLLELQQACKARGMRAYGLTEERLRFQLKE 428
            :..||...||:.||.:|:.:..||::|..|||:||...||:|||:.|||...|..|| :|.||.:
plant   369 SPFGTDAYLRYMLRKRLQEIKKDDKLIKAEGVESLSEAELRQACRERGMLQLGSVEE-MREQLVD 432

  Fly   429 WIDLSLNEQVPPTLLLLSRTMLISDDSITTDKLKETIRVLP----DAVGAHTRHAIGESEGKVDN 489
            |:|||||..||.:||:|||:..::......:.::.|:..||    |.||.   .|:...:...:.
plant   433 WLDLSLNHSVPSSLLILSRSFSMAGKLKPEEAVQATLSSLPDEVVDTVGV---TALSSEDSVSER 494

  Fly   490 KTKIEIIKEEERKIREEREEEREETIAKRSAIKEEIPAPYVFAEKLSGSQDL-LDHKEQSSVSET 553
            |.|:|.::.:|..|:||.|||.|| :||             ..|..|..:|: ||....|:..:.
plant   495 KRKLEYLEMQEELIKEEEEEEEEE-MAK-------------MKESASSQKDVALDEMMASTAKDA 545

  Fly   554 DKGISSTDVQL------LSEALKTLSSDKQLVVEKET-IKELKEELADYK--------EDVEELR 603
            ::...:..::.      ||.||..|:|...:.:|:|. :|.:|:|:..|.        :|.|:.|
plant   546 NEQAKAKTLEKHEQLCELSRALAVLASASSVSMEREEFLKLVKKEVDLYNSMVEKGGTDDEEDAR 610

  Fly   604 EVRQVVKEPVRES-------RAAKLLYNRVNKMISQLDNVLNDLEARQHQIKQAESSDYAASSPT 661
            :.....:|....|       :.:..|.:||..|:.:|:..::|::.:.....:....||...
plant   611 KAYLAAREDSDRSAQKAIADKTSSALLDRVETMLQKLEKEIDDVDNKIGNRWRLLDRDYDGK--- 672

  Fly   662 VEPQQMVHIDELVATIRRMKEASDEERFKVVGDLLVKLDADKDGVISVNEITKAVQSI-DREATN 725
            |.|      ||:......:|:...:|.   :.:|:..|..||||.|.|.::.|....| |.||..
plant   673 VSP------DEVALAAMYLKDTLGKEG---IQELIQNLSKDKDGKILVEDLVKLASEIEDAEAEE 728

  Fly   726 IDK 728
            .|:
plant   729 TDE 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Letm1	NP_611922.1	LETM1_RBD	219..450	CDD:462258	116/234 (50%)
		PRK03918	<543..>916	CDD:235175	47/209 (22%)
LETM2	NP_176732.2	LETM1_RBD	221..453	CDD:462258	116/233 (50%)
		EF-hand_7	655..719	CDD:463900	17/75 (23%)