Protein Alignment Letm1 and Letm1

DIOPT Version :10

• Sequence 1: NP_611922.1
• Gene: Letm1 / 37912
• FlyBaseID: FBgn0284252
• Length: 1013
• Species: Drosophila melanogaster
• Sequence 2: NP_062668.1
• Gene: Letm1 / 56384
• MGIID: 1932557
• Length: 738
• Species: Mus musculus
• Alignment Length: 734
• Identity: 272/734 - (37%)
• Similarity: 413/734 - (56%)
• Gaps: 130/734 - (17%)

  Fly   146 KGQNASATAGSTSATASTTSLAKTADKS------VAKP------KKPLRTRIWDELVHYYHGFRL 198
            :|.::|:..|..|....:....|..:|.      |..|      :|.|..::.|||.||||||||
Mouse   105 RGWHSSSPLGEDSVIEKSLKSLKDKNKKLEEGGPVYSPPAQVVVRKSLGQKVLDELRHYYHGFRL 169

  Fly   199 LFIDVAICSKLLWRVLNGKTLTRRENKQLQRTTSDLFRLIPFSVFIIVPFMELLLPLFIKFFPGM 263
            |:||..|.:::|||:|||.||||||.:|..|..:|||||:||.||::|||||.|||:.:|.||.|
Mouse   170 LWIDTKIAARMLWRILNGHTLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVVVKLFPNM 234

  Fly   264 LPSTFQTSTDRQEKLRQSLSVRLEVAKFLQQTLDQMPVQHKEHSSEEAKQFEAFFTKIRNPTEPV 328
            |||||:|.:.::|:|::.|.|:||:|||||.|:::|.:::|.......|.|.|||.|||...|..
Mouse   235 LPSTFETQSIKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGNATKDFSAFFQKIRETGERP 299

  Fly   329 SNDEIIKFAKRFDDEITLDSLSREQLAALCRVLELNTIGTTTLLRFQLRLKLRSLATDDRVIARE 393
            ||:||::|:|.|:||:|||:|:|.||.|||::|||.:|||...|||||.::|||:..||::|:.|
Mouse   300 SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLISEE 364

  Fly   394 GVDSLDLLELQQACKARGMRAYGLTEERLRFQLKEWIDLSLNEQVPPTLLLLSRTMLISDDSITT 458
            |||||.:.|||.||:||||||.|:||:||:.|||:|:||.|:.::|.:||:|||.|.:.|.....
Mouse   365 GVDSLTVKELQAACRARGMRALGVTEDRLKGQLKQWLDLHLHHEIPTSLLILSRAMYLPDTLSPA 429

  Fly   459 DKLKETIRVLPDAVGAHTRHAIGESEG-KVDNKTKIEIIKEEERKIREEREEEREETIAKRSAIK 522
            |:||.|::.||:.|....:..:.|.|| |||||.|:|...:||..|::|..||.:........|:
Mouse   430 DQLKSTLQTLPEIVAKEAQVKVAEVEGEKVDNKAKLEATLQEEAAIQQEHLEELKRASEAVKDIQ 494

  Fly   523 EEI------------PAPYVFAEKLSGSQDLLDHKEQSSVSETDKG--ISSTDVQLLSEALKTLS 573
            .|:            |.|.| .:.:..|:.|.|   .:.|.|..||  |:..::.:||:|...|.
Mouse   495 PEVAEATLPGRPGPEPQPPV-DDVILPSEVLTD---TAPVLEGLKGEEITKEEIDILSDACSKLQ 555

  Fly   574 SDKQ-LVVEKETIKELKEELADYKEDVEEL-REVRQVVKEP-VRESRAAKLLYNRVNKMISQLDN 635
            ..|: |..|||.::.|||::.||.||::|: :|:.:..:|. :.||.|:|.|..||.:||.|:|.
Mouse   556 EQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYIEESAASKRLSKRVQQMIGQIDG 620

  Fly   636 VLNDLEARQHQIKQAESSDYAASSPTVEPQQMVHIDELVATIRRMKEASDEERFKVVGDLLVKLD 700
            ::..||..|...|...|.    |:||.|
Mouse   621 LITQLETTQQDGKLGPSQ----STPTGE------------------------------------- 644

  Fly   701 ADKDGVISVNEITKAVQSIDREATNIDKKQLEEFTELLSKLASRRRHEEIVHIDDLMNNIKVLKE 765
                .|||:                         |||:|.:      ::|.||.:    .|::..
Mouse   645 ----SVISI-------------------------TELISAM------KQIKHIPE----HKLISL 670

  Fly   766 TSDEARLKHIEAVLEKFDADKDGVVTVNDIRKVLESIGRDNIKLSDKAIEELISLLDKEQVLQAE 830
            ||             ..|.:|||.:.::|:.||::.:.::::::|...:.|:::.|:||:  :.|
Mouse   671 TS-------------ALDDNKDGNINIDDLVKVIDLVNKEDVQISTTQVAEIVATLEKEE--KIE 720

  Fly   831 QKIEKAIAKSMKEAEKLKS 849
            :| |||..|:.|||.::|:
Mouse   721 EK-EKAKEKAEKEAAEVKN 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Letm1	NP_611922.1	LETM1_RBD	219..450	CDD:462258	128/230 (56%)
		PRK03918	<543..>916	CDD:235175	80/312 (26%)
Letm1	NP_062668.1	LETM1_RBD	190..421	CDD:462258	124/230 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	719..738		3/18 (17%)