DRSC/TRiP Functional Genomics Resources

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Protein Alignment Letm1 and LETM1

DIOPT Version :10

Sequence 1:NP_611922.1 Gene:Letm1 / 37912 FlyBaseID:FBgn0284252 Length:1013 Species:Drosophila melanogaster
Sequence 2:NP_036450.1 Gene:LETM1 / 3954 HGNCID:6556 Length:739 Species:Homo sapiens


Alignment Length:781 Identity:279/781 - (35%)
Similarity:426/781 - (54%) Gaps:164/781 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 RHLHTSRTLLETSSSKIDATVKKLKNQQKEKVEEIMKEVANGQAAAVRASSAATATASSEKGQNA 150
            |..|:||.:.:  .|.::.::|.||::.| |:||         ...|.:..|....         
Human   106 RGWHSSRPVRD--DSVVEKSLKSLKDKNK-KLEE---------GGPVYSPPAEVVV--------- 149

  Fly   151 SATAGSTSATASTTSLAKTADKSVAKPKKPLRTRIWDELVHYYHGFRLLFIDVAICSKLLWRVLN 215
                                       ||.|..|:.|||.|||||||||:||..|.:::|||:||
Human   150 ---------------------------KKSLGQRVLDELKHYYHGFRLLWIDTKIAARMLWRILN 187

  Fly   216 GKTLTRRENKQLQRTTSDLFRLIPFSVFIIVPFMELLLPLFIKFFPGMLPSTFQTSTDRQEKLRQ 280
            |.:|||||.:|..|..:|||||:||.||::|||||.|||:.:|.||.||||||:|.:.::|:|::
Human   188 GHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKK 252

  Fly   281 SLSVRLEVAKFLQQTLDQMPVQHKEHSSEEAKQFEAFFTKIRNPTEPVSNDEIIKFAKRFDDEIT 345
            .|.|:||:|||||.|:::|.:::|.......|.|..||.|||...|..||:||::|:|.|:||:|
Human   253 ELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELT 317

  Fly   346 LDSLSREQLAALCRVLELNTIGTTTLLRFQLRLKLRSLATDDRVIAREGVDSLDLLELQQACKAR 410
            ||:|:|.||.|||::|||.:|||...|||||.::|||:..||::||.||||||::.|||.||:||
Human   318 LDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRAR 382

  Fly   411 GMRAYGLTEERLRFQLKEWIDLSLNEQVPPTLLLLSRTMLISDDSITTDKLKETIRVLPDAVGAH 475
            ||||.|:||:|||.|||:|:||.|::::|.:||:|||.|.:.|.....|:||.|::.||:.|...
Human   383 GMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKE 447

  Fly   476 TRHAIGESEG-KVDNKTKIEIIKEEERKIREEREEEREETIAKRSAIKEEI-PAPYVFAEKLSGS 538
            .:..:.|.|| :||||.|:|...:||..|   ::|.||:.:.|||.:.::. |...|.|.:..|:
Human   448 AQVKVAEVEGEQVDNKAKLEATLQEEAAI---QQEHREKELQKRSEVAKDFEPERVVAAPQRPGT 509

  Fly   539 QDLLDHKEQSSVSET------------DKGISSTDVQLLSEALKTLSSDKQ-LVVEKETIKELKE 590
            :...:..:....|||            ::.|:..::.:||:|...|...|: |..|||.::.|||
Human   510 EPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKE 574

  Fly   591 ELADYKEDVEEL-REVRQVVKEP-VRESRAAKLLYNRVNKMISQLDNVLNDLEARQHQIKQAESS 653
            ::.||.||::|: :|:.:..:|. |.||:|:|.|..||.:||.|:|.:::.||..|...|.|.  
Human   575 DVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAP-- 637

  Fly   654 DYAASSPTVEPQQMVHIDELVATIRRMKEASDEERFKVVGDLLVKLDADKDGVISVNEITKAVQS 718
              |...||.|                                         .||||.|:..|:  
Human   638 --ANGMPTGE-----------------------------------------NVISVAELINAM-- 657

  Fly   719 IDREATNIDKKQLEEFTELLSKLASRRRHEEIVHIDDLMNNIKVLKETSDEARLKHIEAVLEKFD 783
                                         :::.||              .|::|..:.|.|   |
Human   658 -----------------------------KQVKHI--------------PESKLTSLAAAL---D 676

  Fly   784 ADKDGVVTVNDIRKVLESIGRDNIKLSDKAIEELISLLDKEQVLQAEQKIEKAIAKSMKEAEKLK 848
            .:|||.|.::|:.||:|.:.::::.:|...:.|:::.|:||:  :.|:| |||..|:.||..::|
Human   677 ENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEE--KVEEK-EKAKEKAEKEVAEVK 738

  Fly   849 S 849
            |
Human   739 S 739

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Letm1NP_611922.1 LETM1_RBD 219..450 CDD:462258 129/230 (56%)
PRK03918 <543..>916 CDD:235175 80/322 (25%)
LETM1NP_036450.1 LETM1_RBD 191..422 CDD:462258 129/230 (56%)
CwlO1 424..>638 CDD:443091 70/220 (32%)
FRQ1 602..>712 CDD:444056 42/202 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..739 8/23 (35%)

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