DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha4T2 and PRE6

DIOPT Version :9

Sequence 1:	NP_001286844.1	Gene:	Prosalpha4T2 / 37910	FlyBaseID:	FBgn0017556	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_014604.1	Gene:	PRE6 / 854119	SGDID:	S000005398	Length:	254	Species:	Saccharomyces cerevisiae

Alignment Length:	249	Identity:	108/249 - (43%)
Similarity:	165/249 - (66%)	Gaps:	2/249 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YDRAVTIYSPDGHLLQVEYAQEAVRRGSTVMGLRTNNAIVIGVEKRSVGDLQEERMV-RKICMLD 68
            ||||::|:|||||:.|||||.|||:||:..:|::..|.:|:|.|:||...||:.|:. .|:..:|
Yeast     4 YDRALSIFSPDGHIFQVEYALEAVKRGTCAVGVKGKNCVVLGCERRSTLKLQDTRITPSKVSKID 68

  Fly    69 DHVVMTFSGLTADARILVSRAQMEAQSHRLNFEKPTTVEYITRYIAQLKQNYTQSNGRRPFGLSC 133
            .|||::||||.||:|||:.:|::|||||||..|.|.||||:|||:|.::|.||||.|.||||:|.
Yeast    69 SHVVLSFSGLNADSRILIEKARVEAQSHRLTLEDPVTVEYLTRYVAGVQQRYTQSGGVRPFGVST 133

  Fly   134 LVGGFD-EDGTPHLFQTDPSGIFYEWRANTTGRSSQPVRDYMEKHADEILTIADEAAAIKHIVRT 197
            |:.||| .|..|.|:||:||||:..|.|.|.||:|:.||:::||:.|.....|.....:|..||:
Yeast   134 LIAGFDPRDDEPKLYQTEPSGIYSSWSAQTIGRNSKTVREFLEKNYDRKEPPATVEECVKLTVRS 198

  Fly   198 LVSVSSLNHTQMEVAVLKYRQPLRMIDHQVLADLERTVRREIEDEAEASRRPRA 251
            |:.|.......:|:.|:|....:..:..:.:......:.:|.:::.|..::.::
Yeast   199 LLEVVQTGAKNIEITVVKPDSDIVALSSEEINQYVTQIEQEKQEQQEQDKKKKS 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha4T2	NP_001286844.1	arc_protsome_A	5..215	CDD:163366	105/211 (50%)
Prosalpha4T2	NP_001286844.1	Ntn_hydrolase	5..214	CDD:294319	104/210 (50%)
PRE6	NP_014604.1	proteasome_alpha_type_7	4..215	CDD:239724	104/210 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345388
Domainoid	1	1.000	202	1.000	Domainoid score	I553
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I615
Isobase	1	0.950	-	0	Normalized mean entropy	S208
OMA	1	1.010	-	-		QHG62217
OrthoFinder	1	1.000	-	-		FOG0002043
OrthoInspector	1	1.000	-	-		otm46601
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11599
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1345
TreeFam	1	0.960	-	-
	12	11.810